Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYH7
  • Mouse genes Myh7
  • Rat genes Myh7
  • Zfish genes myh7,myh7l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Myh7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Myh7	IMP		Rat	PMID:15471982|RGD:1581170
Molecular Function	GO:0016887	ATP hydrolysis activity	Myh7	IMP		Rat	PMID:15471982|RGD:1581170
Molecular Function	GO:0042802	identical protein binding	Myh7	IPI	RGD:62030	Rat	PMID:3693405|RGD:1581165
Molecular Function	GO:0000146	microfilament motor activity	MYH7	IDA		Human	PMID:15621050
Molecular Function	GO:0000146	microfilament motor activity	MYH7	IMP		Human	PMID:16088376
Molecular Function	GO:0000146	microfilament motor activity	Myh7	IMP		Rat	PMID:15020307|RGD:1581168
Molecular Function	GO:0005515	protein binding	MYH7	IPI	UniProtKB:Q14896	Human	PMID:17192269
Molecular Function	GO:0005515	protein binding	MYH7	IPI	UniProtKB:Q96DD0	Human	PMID:20847312
Molecular Function	GO:0005515	protein binding	MYH7	IPI	UniProtKB:Q9BQD3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MYH7	IPI	UniProtKB:Q5SYC1	Human	PMID:32296183
Molecular Function	GO:0044877	protein-containing complex binding	Myh7	IDA		Rat	PMID:3693405|RGD:1581165
Cellular Component	GO:0005737	cytoplasm	Myh7	IDA		Mouse	PMID:25139234
Cellular Component	GO:0005859	muscle myosin complex	Myh7	IDA		Rat	PMID:3693405|RGD:1581165
Cellular Component	GO:0030016	myofibril	Myh7	IDA		Mouse	PMID:21884692
Cellular Component	GO:0030016	myofibril	Myh7	IDA		Mouse	PMID:9884344
Cellular Component	GO:0030016	myofibril	Myh7	IDA		Rat	PMID:26150528|RGD:12910991
Cellular Component	GO:0016459	myosin complex	Myh7	IDA		Mouse	PMID:8482409
Cellular Component	GO:0016459	myosin complex	Myh7	IDA		Mouse	PMID:9884344
Cellular Component	GO:0032982	myosin filament	MYH7	IDA		Human	PMID:19336582
Cellular Component	GO:0032982	myosin filament	Myh7	IDA		Rat	PMID:26150528|RGD:12910991
Cellular Component	GO:0030017	sarcomere	Myh7	IDA		Rat	PMID:26150528|RGD:12910991
Cellular Component	GO:0001725	stress fiber	Myh7	IDA		Mouse	PMID:21126233
Cellular Component	GO:0030018	Z disc	Myh7	IDA		Mouse	PMID:21126233
Biological Process	GO:0007512	adult heart development	MYH7	IMP		Human	PMID:15856146
Biological Process	GO:0007568	aging	Myh7	IEP		Rat	PMID:1888877|RGD:12792975
Biological Process	GO:0046034	ATP metabolic process	MYH7	IDA		Human	PMID:15621050
Biological Process	GO:0060048	cardiac muscle contraction	MYH7	IMP		Human	PMID:7883988
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Myh7	IDA		Mouse	PMID:24137001
Biological Process	GO:0003231	cardiac ventricle development	myh7l	IGI	ZFIN:ZDB-CRISPR-221207-1	Zfish	PMID:35463789
Biological Process	GO:0003231	cardiac ventricle development	myh7	IGI	ZFIN:ZDB-CRISPR-221207-1	Zfish	PMID:35463789
Biological Process	GO:1905243	cellular response to 3,3',5-triiodo-L-thyronine	Myh7	IEP		Rat	PMID:17111039|RGD:12792968
Biological Process	GO:1904385	cellular response to angiotensin	Myh7	IEP		Rat	PMID:17111039|RGD:12792968
Biological Process	GO:1904385	cellular response to angiotensin	Myh7	IEP		Rat	PMID:27249171|RGD:155646134
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Myh7	IEP		Rat	PMID:27249171|RGD:155646134
Biological Process	GO:0035050	embryonic heart tube development	myh7	IEP		Zfish	PMID:10491254
Biological Process	GO:0006936	muscle contraction	MYH7	IDA		Human	PMID:15621050
Biological Process	GO:0006936	muscle contraction	Myh7	IMP		Rat	PMID:15020307|RGD:1581168
Biological Process	GO:0006936	muscle contraction	Myh7	IMP		Rat	PMID:15471982|RGD:1581170
Biological Process	GO:0030049	muscle filament sliding	MYH7	IMP		Human	PMID:16088376
Biological Process	GO:0030049	muscle filament sliding	MYH7	IMP		Human	PMID:8514894
Biological Process	GO:0002027	regulation of heart rate	MYH7	IDA		Human	PMID:15621050
Biological Process	GO:0031449	regulation of slow-twitch skeletal muscle fiber contraction	MYH7	IMP		Human	PMID:7883988
Biological Process	GO:0002026	regulation of the force of heart contraction	MYH7	IDA		Human	PMID:15621050
Biological Process	GO:0014728	regulation of the force of skeletal muscle contraction	MYH7	IMP		Human	PMID:7883988
Biological Process	GO:0003009	skeletal muscle contraction	MYH7	IMP		Human	PMID:7883988
Biological Process	GO:0006941	striated muscle contraction	MYH7	IDA		Human	PMID:15621050
Biological Process	GO:0014883	transition between fast and slow fiber	Myh7	IDA		Mouse	PMID:18978355
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	MYH7	IMP		Human	PMID:15856146
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	MYH7	IMP		Human	PMID:16754800
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	myh7	IMP	ZFIN:ZDB-GENO-071128-1	Zfish	PMID:17311471

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern