Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYL2
  • Mouse genes Myl2
  • Rat genes Myl2
  • Zfish genes myl2a,myl2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Myl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003785	actin monomer binding	MYL2	IDA		Human	PMID:9180271
Molecular Function	GO:0005509	calcium ion binding	MYL2	IDA		Human	PMID:11102452
Molecular Function	GO:0005515	protein binding	MYL2	IPI	UniProtKB:Q99972	Human	PMID:11773029
Molecular Function	GO:0005515	protein binding	MYL2	IPI	UniProtKB:P35125-3	Human	PMID:16555005
Molecular Function	GO:0005515	protein binding	MYL2	IPI	UniProtKB:P78412	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MYL2	IPI	UniProtKB:Q9UIG4	Human	PMID:32296183
Molecular Function	GO:0008307	structural constituent of muscle	MYL2	IMP		Human	PMID:23365102
Molecular Function	GO:0008307	structural constituent of muscle	MYL2	IMP		Human	PMID:32453731
Cellular Component	GO:0015629	actin cytoskeleton	MYL2	IDA		Human	PMID:17043135
Cellular Component	GO:0097512	cardiac myofibril	MYL2	IDA		Human	PMID:25771144
Cellular Component	GO:0043292	contractile fiber	Myl2	IDA		Rat	PMID:12002261|RGD:1600170
Cellular Component	GO:0043292	contractile fiber	Myl2	IDA		Rat	PMID:9409484|RGD:1600167
Cellular Component	GO:0005856	cytoskeleton	MYL2	IDA		Human	PMID:17043135
Cellular Component	GO:0030016	myofibril	Myl2	IDA		Mouse	PMID:11356630
Cellular Component	GO:0030016	myofibril	Myl2	IDA		Rat	PMID:11448842|RGD:1600178
Biological Process	GO:0060048	cardiac muscle contraction	Myl2	IGI	MGI:MGI:107956	Mouse	PMID:15308581
Biological Process	GO:0060048	cardiac muscle contraction	Myl2	IDA		Rat	PMID:11448842|RGD:1600178
Biological Process	GO:0060048	cardiac muscle contraction	Myl2	IMP		Rat	PMID:12002261|RGD:1600170
Biological Process	GO:0060048	cardiac muscle contraction	Myl2	IMP		Rat	PMID:9409484|RGD:1600167
Biological Process	GO:0055003	cardiac myofibril assembly	Myl2	IMP	MGI:MGI:2385922	Mouse	PMID:9422794
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Myl2	IEP		Rat	PMID:7657802|RGD:1580138
Biological Process	GO:0060047	heart contraction	Myl2	IDA		Mouse	MGI:MGI:3688731|PMID:10409661
Biological Process	GO:0060047	heart contraction	Myl2	IDA		Mouse	PMID:8777429
Biological Process	GO:0007507	heart development	Myl2	IDA		Mouse	MGI:MGI:3688731|PMID:10409661
Biological Process	GO:0007507	heart development	Myl2	IMP	MGI:MGI:2385922	Mouse	PMID:9422794
Biological Process	GO:0003007	heart morphogenesis	Myl2	IGI	MGI:MGI:107956	Mouse	PMID:15308581
Biological Process	GO:0055001	muscle cell development	Myl2	IGI	MGI:MGI:107956	Mouse	PMID:15308581
Biological Process	GO:0042694	muscle cell fate specification	Myl2	IMP		Mouse	PMID:1379240
Biological Process	GO:0030308	negative regulation of cell growth	MYL2	IMP		Human	PMID:15824735
Biological Process	GO:0098735	positive regulation of the force of heart contraction	Myl2	IDA		Mouse	MGI:MGI:5688843|PMID:16908724
Biological Process	GO:0009791	post-embryonic development	Myl2	IGI	MGI:MGI:107956	Mouse	PMID:15308581
Biological Process	GO:0002026	regulation of the force of heart contraction	Myl2	IDA		Rat	PMID:15331360|RGD:10400860
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	MYL2	IMP		Human	PMID:8673105

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern