Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NACC2
  • Mouse genes Nacc2
  • Rat genes Nacc2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nacc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	NACC2	IDA		Human	PMID:22926524
Molecular Function	GO:0042826	histone deacetylase binding	NACC2	IPI	UniProtKB:Q13547	Human	PMID:22926524
Molecular Function	GO:0042826	histone deacetylase binding	NACC2	IPI	UniProtKB:Q92769	Human	PMID:22926524
Molecular Function	GO:0005515	protein binding	NACC2	IPI	UniProtKB:O94776	Human	PMID:22926524
Molecular Function	GO:0005515	protein binding	NACC2	IPI	UniProtKB:Q13330	Human	PMID:22926524
Molecular Function	GO:0005515	protein binding	NACC2	IPI	UniProtKB:Q14839	Human	PMID:22926524
Molecular Function	GO:0005515	protein binding	NACC2	IPI	UniProtKB:Q9BTC8	Human	PMID:22926524
Molecular Function	GO:0005515	protein binding	NACC2	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	NACC2	IDA		Human	PMID:22926524
Molecular Function	GO:0044877	protein-containing complex binding	NACC2	IPI	ComplexPortal:CPX-880	Human	PMID:22926524
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NACC2	IDA		Human	PMID:22926524
Cellular Component	GO:0000785	chromatin	NACC2	IDA		Human	PMID:22926524
Cellular Component	GO:0005739	mitochondrion	NACC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	NACC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NACC2	IDA		Human	PMID:22926524
Biological Process	GO:0008285	negative regulation of cell population proliferation	NACC2	IDA		Human	PMID:22926524
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NACC2	IDA		Human	PMID:22926524
Biological Process	GO:1900477	negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter	NACC2	IDA		Human	PMID:22926524
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NACC2	IMP		Human	PMID:22926524
Biological Process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NACC2	IDA		Human	PMID:22926524
Biological Process	GO:0051260	protein homooligomerization	NACC2	IDA		Human	PMID:22926524
Biological Process	GO:0031503	protein-containing complex localization	NACC2	IDA		Human	PMID:22926524

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern