Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NAIP
  • Mouse genes Naip5
  • Rat genes Naip6
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Naip5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	NAIP	IMP		Human	PMID:21371431
Molecular Function	GO:0005524	ATP binding	Naip5	IDA		Mouse	MGI:MGI:6120354|PMID:29182158
Molecular Function	GO:0005515	protein binding	NAIP	IPI	UniProtKB:Q15750	Human	PMID:11865055
Molecular Function	GO:0005515	protein binding	NAIP	IPI	UniProtKB:O14727	Human	PMID:21371431
Molecular Function	GO:0005515	protein binding	Naip5	IPI	UniProtKB:P06179|UniProtKB:Q3UP24	Mouse	MGI:MGI:5917766|PMID:26449475
Molecular Function	GO:0005515	protein binding	Naip5	IPI	UniProtKB:P06179|UniProtKB:Q3UP24	Mouse	MGI:MGI:5926614|PMID:26585513
Molecular Function	GO:0005515	protein binding	Naip5	IPI	UniProtKB:Q3UP24	Mouse	MGI:MGI:6355647|PMID:29146805
Molecular Function	GO:0005515	protein binding	Naip5	IPI	UniProtKB:Q3UP24	Mouse	MGI:MGI:5917987|PMID:23765277
Molecular Function	GO:0005515	protein binding	Naip5	IPI	UniProtKB:P06179|UniProtKB:Q48824	Mouse	MGI:MGI:5293542|PMID:21918512
Molecular Function	GO:0005515	protein binding	Naip5	IPI	UniProtKB:P06179|UniProtKB:Q3UP24	Mouse	MGI:MGI:5914198|PMID:26449474
Molecular Function	GO:0120283	protein serine/threonine kinase binding	NAIP	IPI	UniProtKB:P27448	Human	PMID:11865055
Cellular Component	GO:0005737	cytoplasm	Naip6	IDA		Rat	PMID:9183692|RGD:2317255
Cellular Component	GO:0072557	IPAF inflammasome complex	Naip5	IDA		Mouse	MGI:MGI:5289703|PMID:21874021
Cellular Component	GO:0072557	IPAF inflammasome complex	Naip5	IDA		Mouse	MGI:MGI:6120354|PMID:29182158
Cellular Component	GO:0043005	neuron projection	Naip6	IDA		Rat	PMID:9183692|RGD:2317255
Cellular Component	GO:0043025	neuronal cell body	Naip6	IDA		Rat	PMID:9183692|RGD:2317255
Cellular Component	GO:0043204	perikaryon	Naip6	IDA		Rat	PMID:9183692|RGD:2317255
Biological Process	GO:0042742	defense response to bacterium	Naip5	IMP		Mouse	MGI:MGI:5289703|PMID:21874021
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Naip5	IMP		Mouse	MGI:MGI:6120354|PMID:29182158
Biological Process	GO:0016045	detection of bacterium	Naip5	IMP		Mouse	MGI:MGI:5289703|PMID:21874021
Biological Process	GO:0035635	entry of bacterium into host cell	Naip5	IDA		Mouse	PMID:12526741
Biological Process	GO:0035635	entry of bacterium into host cell	Naip5	IMP	MGI:MGI:3769036	Mouse	PMID:12526741
Biological Process	GO:0006954	inflammatory response	Naip5	IMP		Mouse	MGI:MGI:5289703|PMID:21874021
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	NAIP	IDA		Human	PMID:11896143
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	NAIP	IDA		Human	PMID:11865055
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Naip5	IDA		Mouse	MGI:MGI:6120354|PMID:29182158
Biological Process	GO:0046330	positive regulation of JNK cascade	NAIP	IDA		Human	PMID:11865055
Biological Process	GO:0070269	pyroptosis	Naip5	IMP		Mouse	MGI:MGI:5289703|PMID:21874021
Biological Process	GO:0042981	regulation of apoptotic process	NAIP	IDA		Human	PMID:11865055
Biological Process	GO:0043200	response to amino acid	Naip6	IEP		Rat	PMID:12547647|RGD:634756
Biological Process	GO:0048678	response to axon injury	Naip6	IEP		Rat	PMID:12617963|RGD:1299309

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern