Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NALCN
  • Mouse genes Nalcn
  • Rat genes Nalcn
  • Zfish genes nalcn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nalcn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0022840	leak channel activity	Nalcn	IMP		Mouse	MGI:MGI:3818816|PMID:17448995
Molecular Function	GO:0005261	monoatomic cation channel activity	Nalcn	IDA		Mouse	MGI:MGI:3818816|PMID:17448995
Molecular Function	GO:0005515	protein binding	NALCN	IPI	UniProtKB:P20309	Human	PMID:19575010
Molecular Function	GO:0005515	protein binding	NALCN	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Nalcn	IPI	UniProtKB:Q0KK59,UniProtKB:Q8BLN6	Mouse	MGI:MGI:4880821|PMID:21040849
Molecular Function	GO:0005515	protein binding	Nalcn	IPI	UniProtKB:Q9ERZ3	Mouse	MGI:MGI:5784983|PMID:19575010
Molecular Function	GO:0005515	protein binding	Nalcn	IPI	UniProtKB:Q8BLN6	Mouse	MGI:MGI:3833159|PMID:19092807
Molecular Function	GO:0005515	protein binding	Nalcn	IPI	UniProtKB:Q8BLN6	Mouse	MGI:MGI:4880821|PMID:21040849
Molecular Function	GO:0005248	voltage-gated sodium channel activity	NALCN	IMP		Human	PMID:32494638
Molecular Function	GO:0005248	voltage-gated sodium channel activity	NALCN	IDA		Human	PMID:32698188
Cellular Component	GO:0005886	plasma membrane	NALCN	IDA		Human	PMID:31409833
Cellular Component	GO:0005886	plasma membrane	NALCN	IDA		Human	PMID:32698188
Biological Process	GO:0070588	calcium ion transmembrane transport	Nalcn	IDA		Mouse	MGI:MGI:3818816|PMID:17448995
Biological Process	GO:0071805	potassium ion transmembrane transport	Nalcn	IDA		Mouse	MGI:MGI:3818816|PMID:17448995
Biological Process	GO:0060075	regulation of resting membrane potential	Nalcn	IMP		Mouse	MGI:MGI:3818816|PMID:17448995
Biological Process	GO:0035725	sodium ion transmembrane transport	Nalcn	IDA		Mouse	MGI:MGI:3818816|PMID:17448995

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern