Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NAMPT
  • Mouse genes Nampt
  • Rat genes Nampt
  • Zfish genes nampt1,nampt2,nampt3.1,nampt3.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nampt

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	Nampt	IDA		Rat	PMID:18768589|RGD:2311081
Molecular Function	GO:1901363	heterocyclic compound binding	Nampt	IDA		Rat	PMID:16901503|RGD:1642344
Molecular Function	GO:0042802	identical protein binding	NAMPT	IPI	UniProtKB:P43490	Human	PMID:16783377
Molecular Function	GO:0042802	identical protein binding	NAMPT	IPI	UniProtKB:P43490	Human	PMID:19666527
Molecular Function	GO:0042802	identical protein binding	Nampt	IPI	UniProtKB:Q99KQ4	Mouse	MGI:MGI:5915892|PMID:16783377
Molecular Function	GO:0042802	identical protein binding	Nampt	IPI	UniProtKB:Q99KQ4	Mouse	MGI:MGI:5915408|PMID:16783373
Molecular Function	GO:0042802	identical protein binding	Nampt	IDA		Rat	PMID:16901503|RGD:1642344
Molecular Function	GO:0047280	nicotinamide phosphoribosyltransferase activity	Nampt	IDA		Mouse	PMID:15381699
Molecular Function	GO:0047280	nicotinamide phosphoribosyltransferase activity	Nampt	IDA		Rat	PMID:4402158|RGD:1642346
Molecular Function	GO:0000166	nucleotide binding	Nampt	IDA		Rat	PMID:16901503|RGD:1642344
Molecular Function	GO:0005515	protein binding	NAMPT	IPI	UniProtKB:P02792	Human	PMID:18486613
Molecular Function	GO:0005515	protein binding	NAMPT	IPI	UniProtKB:P03886	Human	PMID:18486613
Molecular Function	GO:0005515	protein binding	NAMPT	IPI	UniProtKB:Q01628	Human	PMID:18486613
Molecular Function	GO:0005515	protein binding	NAMPT	IPI	UniProtKB:Q70CQ1-2	Human	PMID:32296183
Cellular Component	GO:0030054	cell junction	NAMPT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	Nampt	IDA		Mouse	PMID:15381699
Cellular Component	GO:0005737	cytoplasm	Nampt	IDA		Rat	PMID:12782293|RGD:633608
Cellular Component	GO:0070062	extracellular exosome	NAMPT	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	NAMPT	HDA		Human	PMID:23533145
Cellular Component	GO:0016607	nuclear speck	NAMPT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nampt	IDA		Rat	PMID:12782293|RGD:633608
Cellular Component	GO:0005886	plasma membrane	Nampt	IDA		Rat	PMID:28163205|RGD:13781883
Biological Process	GO:0007568	aging	Nampt	IEP		Rat	PMID:26547053|RGD:13781893
Biological Process	GO:1904646	cellular response to amyloid-beta	Nampt	IEP		Rat	PMID:28714019|RGD:13781878
Biological Process	GO:0071479	cellular response to ionizing radiation	Nampt	IEP		Rat	PMID:27681750|RGD:13781886
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Nampt	IEP		Rat	PMID:28528966|RGD:13781879
Biological Process	GO:0032922	circadian regulation of gene expression	Nampt	IMP		Mouse	MGI:MGI:3843127|PMID:19299583
Biological Process	GO:0007623	circadian rhythm	Nampt	IEP		Mouse	MGI:MGI:3843127|PMID:19299583
Biological Process	GO:0007623	circadian rhythm	Nampt	IEP		Rat	PMID:26547053|RGD:13781893
Biological Process	GO:0007565	female pregnancy	Nampt	IEP		Rat	PMID:17641280|RGD:1642342
Biological Process	GO:0030097	hemopoiesis	nampt1	IMP	ZFIN:ZDB-MRPHLNO-200320-1	Zfish	PMID:31366618
Biological Process	GO:0001774	microglial cell activation	Nampt	IMP		Rat	PMID:28528966|RGD:13781879
Biological Process	GO:0009435	NAD biosynthetic process	Nampt	IDA		Mouse	PMID:15381699
Biological Process	GO:0010507	negative regulation of autophagy	Nampt	IMP		Rat	PMID:26601421|RGD:13781888
Biological Process	GO:2000773	negative regulation of cellular senescence	Nampt	IDA		Rat	PMID:28125705|RGD:13781884
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	NAMPT	IDA		Human	PMID:19727662
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Nampt	IMP		Rat	PMID:18952695|RGD:2311234
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NAMPT	IDA		Human	PMID:23001182
Biological Process	GO:0014916	regulation of lung blood pressure	Nampt	IMP		Rat	PMID:28438162|RGD:13781881
Biological Process	GO:1905377	response to D-galactose	Nampt	IEP		Rat	PMID:28163205|RGD:13781883
Biological Process	GO:0014070	response to organic cyclic compound	Nampt	IEP		Rat	PMID:17418807|RGD:1642339

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern