Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NANOG,NANOGP1,NANOGP8
  • Mouse genes Nanog
  • Rat genes Nanog
  • Zfish genes nanog
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nanog

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nanog	IDA		Mouse	PMID:18467660
Molecular Function	GO:0003682	chromatin binding	nanog	IDA		Zfish	PMID:30674556
Molecular Function	GO:0003677	DNA binding	NANOG	IDA		Human	PMID:16153702
Molecular Function	GO:0003677	DNA binding	NANOG	IDA		Human	PMID:19427902
Molecular Function	GO:0003677	DNA binding	Nanog	IDA		Mouse	PMID:23798425
Molecular Function	GO:0003677	DNA binding	Nanog	IDA		Mouse	PMID:12787504
Molecular Function	GO:0003677	DNA binding	Nanog	IDA		Mouse	PMID:16518401
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nanog	IDA		Mouse	MGI:MGI:5882883|PMID:18957414
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NANOG	IDA		Human	PMID:16153702
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nanog	IMP		Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nanog	IMP		Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0042802	identical protein binding	Nanog	IPI	UniProtKB:Q80Z64-1	Mouse	MGI:MGI:3789412|PMID:18436640
Molecular Function	GO:0042802	identical protein binding	nanog	IPI	ZFIN:ZDB-GENE-030131-5486	Zfish	PMID:21967637
Molecular Function	GO:0070577	lysine-acetylated histone binding	Nanog	IDA		Mouse	PMID:23798425
Molecular Function	GO:0005515	protein binding	NANOG	IPI	UniProtKB:Q9BSM1	Human	PMID:26687479
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:Q5BL09	Mouse	MGI:MGI:4946164|PMID:21076177
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:Q61066|UniProtKB:Q99LI5	Mouse	MGI:MGI:4399017|PMID:17093407
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:P20263|UniProtKB:P70414|UniProtKB:Q6PR54	Mouse	MGI:MGI:4399017|PMID:17093407
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:P48432|UniProtKB:Q61066|UniProtKB:Q99LI5	Mouse	MGI:MGI:5532893|PMID:23892456
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:Q9ER74	Mouse	MGI:MGI:4946171|PMID:21062744
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:Q99LI5	Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:P01108	Mouse	MGI:MGI:5887185|PMID:26523946
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:Q99LI5	Mouse	MGI:MGI:5448369|PMID:21915945
Molecular Function	GO:0005515	protein binding	Nanog	IPI	UniProtKB:Q9QUR7|UniProtKB:Q13526	Mouse	MGI:MGI:4818823|PMID:20622153
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nanog	IDA		Mouse	MGI:MGI:4946171|PMID:21062744
Molecular Function	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	Nanog	IDA		Mouse	MGI:MGI:5882870|PMID:23040477
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NANOG	IDA		Human	PMID:23708658
Molecular Function	GO:0043565	sequence-specific DNA binding	Nanog	IDA		Mouse	MGI:MGI:4889168|PMID:20937355
Molecular Function	GO:0043565	sequence-specific DNA binding	Nanog	IDA		Mouse	PMID:18400104
Molecular Function	GO:0043565	sequence-specific DNA binding	nanog	IDA		Zfish	PMID:22421047
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NANOG	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NANOG	IDA		Human	PMID:25825768
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Nanog	IDA		Mouse	PMID:20123909
Molecular Function	GO:0008134	transcription factor binding	Nanog	IPI	UniProtKB:Q61539	Mouse	MGI:MGI:5882883|PMID:18957414
Cellular Component	GO:0000785	chromatin	Nanog	IDA		Mouse	PMID:23798425
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NANOGP8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NANOG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	NANOG	IDA		Human	PMID:20458727
Cellular Component	GO:0005654	nucleoplasm	NANOGP8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NANOG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Nanog	IDA		Mouse	MGI:MGI:4946164|PMID:21076177
Cellular Component	GO:0005634	nucleus	NANOGP8	IDA		Human	PMID:16623708
Cellular Component	GO:0005634	nucleus	NANOG	IDA		Human	PMID:18932205
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	MGI:MGI:4889168|PMID:20937355
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:31481660
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:23798425
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:15582778
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:15788452
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:21146513
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:16259959
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:25397698
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:23824537
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:18425773
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:20123909
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:24268575
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:24036311
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:25335925
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:18448678
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Nanog	IDA		Rat	PMID:18196277|RGD:2290188
Biological Process	GO:0030036	actin cytoskeleton organization	nanog	IMP	ZFIN:ZDB-GENO-180917-1	Zfish	PMID:29180568
Biological Process	GO:0030509	BMP signaling pathway	Nanog	IDA		Mouse	PMID:16801560
Biological Process	GO:0043697	cell dedifferentiation	Nanog	IDA		Mouse	MGI:MGI:5882870|PMID:23040477
Biological Process	GO:0030154	cell differentiation	NANOG	IEP		Human	PMID:16501172
Biological Process	GO:0036018	cellular response to erythropoietin	Nanog	IEP		Rat	PMID:24855555|RGD:9589810
Biological Process	GO:0072752	cellular response to rapamycin	Nanog	IEP		Rat	PMID:24296616|RGD:9589808
Biological Process	GO:0006338	chromatin remodeling	nanog	IMP	ZFIN:ZDB-GENO-221020-5	Zfish	PMID:31940339
Biological Process	GO:0043622	cortical microtubule organization	nanog	IMP	ZFIN:ZDB-GENO-180917-1	Zfish	PMID:29180568
Biological Process	GO:0009790	embryo development	Nanog	IMP	MGI:MGI:2664492	Mouse	PMID:12787504
Biological Process	GO:0009880	embryonic pattern specification	Nanog	IEP		Mouse	MGI:MGI:3042348|PMID:15108323
Biological Process	GO:0001706	endoderm formation	nanog	IMP	ZFIN:ZDB-MRPHLNO-120403-3	Zfish	PMID:22421047
Biological Process	GO:0001714	endodermal cell fate specification	NANOG	IDA		Human	PMID:20713518
Biological Process	GO:0090504	epiboly	nanog	IMP	ZFIN:ZDB-GENO-180917-1	Zfish	PMID:29180568
Biological Process	GO:0090504	epiboly	nanog	IMP	ZFIN:ZDB-MRPHLNO-160309-3	Zfish	PMID:21967637
Biological Process	GO:0007369	gastrulation	nanog	IMP	ZFIN:ZDB-MRPHLNO-120403-3	Zfish	PMID:22421047
Biological Process	GO:0007369	gastrulation	nanog	IGI	ZFIN:ZDB-GENE-000710-6,ZFIN:ZDB-MRPHLNO-120403-3	Zfish	PMID:22421047
Biological Process	GO:0010467	gene expression	Nanog	IMP		Mouse	PMID:26005002
Biological Process	GO:0010467	gene expression	Nanog	IMP		Mouse	PMID:17267691
Biological Process	GO:0008406	gonad development	Nanog	IEP		Mouse	MGI:MGI:3042348|PMID:15108323
Biological Process	GO:0001710	mesodermal cell fate commitment	Nanog	IGI	MGI:MGI:109452	Mouse	PMID:16801560
Biological Process	GO:0001710	mesodermal cell fate commitment	Nanog	IDA		Mouse	PMID:16801560
Biological Process	GO:0009825	multidimensional cell growth	Nanog	IEP		Rat	PMID:23273767|RGD:9589809
Biological Process	GO:1904864	negative regulation of beta-catenin-TCF complex assembly	nanog	IMP	ZFIN:ZDB-GENO-220407-2	Zfish	PMID:32702011
Biological Process	GO:1904864	negative regulation of beta-catenin-TCF complex assembly	nanog	IMP	ZFIN:ZDB-GENO-220407-1	Zfish	PMID:32702011
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nanog	IDA		Mouse	PMID:16801560
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	nanog	IGI	ZFIN:ZDB-MRPHLNO-120403-3,ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:32702011
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	nanog	IMP	ZFIN:ZDB-MRPHLNO-120403-3	Zfish	PMID:32702011
Biological Process	GO:0010454	negative regulation of cell fate commitment	Nanog	IGI	MGI:MGI:109452	Mouse	PMID:16801560
Biological Process	GO:0010454	negative regulation of cell fate commitment	Nanog	IDA		Mouse	PMID:16801560
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	nanog	IMP	ZFIN:ZDB-GENO-180917-1	Zfish	PMID:29180568
Biological Process	GO:2000737	negative regulation of stem cell differentiation	Nanog	IDA		Mouse	PMID:17940068
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nanog	IGI	MGI:MGI:1276116	Mouse	PMID:16801560
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nanog	IGI	MGI:MGI:103302	Mouse	PMID:16801560
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nanog	IMP		Mouse	PMID:21385842
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nanog	IDA		Rat	PMID:23924954|RGD:9589807
Biological Process	GO:0034728	nucleosome organization	nanog	IDA		Zfish	PMID:30674556
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	NANOGP8	IDA		Human	PMID:16623708
Biological Process	GO:0008284	positive regulation of cell population proliferation	NANOGP8	IDA		Human	PMID:16623708
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nanog	IDA		Mouse	PMID:16259959
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nanog	IDA		Mouse	MGI:MGI:5882883|PMID:18957414
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nanog	IMP		Mouse	MGI:MGI:4889168|PMID:20937355
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	Nanog	IDA		Mouse	PMID:16259959
Biological Process	GO:2000648	positive regulation of stem cell proliferation	NANOG	IMP		Human	PMID:16501172
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NANOG	IDA		Human	PMID:20713518
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nanog	IMP		Mouse	MGI:MGI:4889168|PMID:20937355
Biological Process	GO:0045595	regulation of cell differentiation	NANOG	IMP		Human	PMID:16501172
Biological Process	GO:0006355	regulation of DNA-templated transcription	NANOG	IDA		Human	PMID:16153702
Biological Process	GO:0006355	regulation of DNA-templated transcription	nanog	IGI	ZFIN:ZDB-GENE-000710-6,ZFIN:ZDB-MRPHLNO-120403-3	Zfish	PMID:22421047
Biological Process	GO:0010468	regulation of gene expression	NANOG	IMP		Human	PMID:18388306
Biological Process	GO:0010468	regulation of gene expression	nanog	IMP	ZFIN:ZDB-GENO-180917-1	Zfish	PMID:29180568
Biological Process	GO:1905936	regulation of germ cell proliferation	nanog	IMP	ZFIN:ZDB-MRPHLNO-120403-3	Zfish	PMID:27125179
Biological Process	GO:2000035	regulation of stem cell division	Nanog	IDA		Mouse	MGI:MGI:5882870|PMID:23040477
Biological Process	GO:0014070	response to organic cyclic compound	Nanog	IEP		Rat	PMID:24134786|RGD:9589818
Biological Process	GO:0010033	response to organic substance	Nanog	IDA		Mouse	PMID:18400104
Biological Process	GO:0032526	response to retinoic acid	Nanog	IDA		Mouse	PMID:18400104
Biological Process	GO:0035019	somatic stem cell population maintenance	NANOG	IMP		Human	PMID:18388306
Biological Process	GO:0035019	somatic stem cell population maintenance	Nanog	IMP	MGI:MGI:2664492	Mouse	PMID:12787504
Biological Process	GO:0035019	somatic stem cell population maintenance	Nanog	IDA		Mouse	PMID:16801560
Biological Process	GO:0035019	somatic stem cell population maintenance	Nanog	IMP		Mouse	PMID:16767105
Biological Process	GO:0035019	somatic stem cell population maintenance	Nanog	IMP		Mouse	PMID:20720539
Biological Process	GO:0048863	stem cell differentiation	Nanog	IDA		Mouse	PMID:17940068
Biological Process	GO:0048863	stem cell differentiation	Nanog	IDA		Mouse	PMID:20123909
Biological Process	GO:0048863	stem cell differentiation	Nanog	IMP		Mouse	PMID:16894029
Biological Process	GO:0048863	stem cell differentiation	Nanog	IEP		Rat	PMID:22211239|RGD:9589812
Biological Process	GO:0017145	stem cell division	Nanog	IDA		Mouse	PMID:12787505
Biological Process	GO:0019827	stem cell population maintenance	NANOG	IEP		Human	PMID:15108323
Biological Process	GO:0019827	stem cell population maintenance	Nanog	IEP		Mouse	MGI:MGI:3042348|PMID:15108323
Biological Process	GO:0019827	stem cell population maintenance	Nanog	IMP		Mouse	MGI:MGI:5905240|PMID:25825768
Biological Process	GO:0019827	stem cell population maintenance	Nanog	IGI	MGI:MGI:1924054	Mouse	PMID:17938240
Biological Process	GO:0019827	stem cell population maintenance	Nanog	IEP		Rat	PMID:20352099|RGD:9589811
Biological Process	GO:0042246	tissue regeneration	Nanog	IEP		Rat	PMID:19845688|RGD:8661679
Biological Process	GO:0106336	yolk syncytial layer development	nanog	IMP	ZFIN:ZDB-GENO-181023-1	Zfish	PMID:29180571

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern