Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NCF1,NCF1B,NCF1C
  • Mouse genes Ncf1
  • Rat genes Ncf1
  • Zfish genes ncf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ncf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035091	phosphatidylinositol binding	NCF1	IDA		Human	PMID:12356722
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	NCF1	IDA		Human	PMID:12356722
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P31146	Human	PMID:11094157
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P13498	Human	PMID:11733522
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:Q8IZP0	Human	PMID:12681507
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:15657040
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:Q15080	Human	PMID:15657040
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:16297854
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P13498	Human	PMID:16326715
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:Q9BUZ4	Human	PMID:16330715
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P60709	Human	PMID:16375898
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P04899	Human	PMID:16782902
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:16782902
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P13498	Human	PMID:17803994
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:19129478
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P78325	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P11142	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:Q05513	Human	PMID:27040869
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:Q9BUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:8280052
Molecular Function	GO:0005515	protein binding	Ncf1	IPI	UniProtKB:Q99LX0	Mouse	MGI:MGI:5825417|PMID:26021615
Molecular Function	GO:0005515	protein binding	Ncf1	IPI	PR:O70145	Mouse	PMID:9490028
Molecular Function	GO:0005515	protein binding	Ncf1	IPI	PR:P97369	Mouse	PMID:9490028
Molecular Function	GO:0017124	SH3 domain binding	NCF1	IPI	UniProtKB:P14598	Human	PMID:7938008
Molecular Function	GO:0017124	SH3 domain binding	NCF1	IPI	UniProtKB:P19878	Human	PMID:7938008
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	NCF1	IMP		Human	PMID:26514923
Molecular Function	GO:0016176	superoxide-generating NADPH oxidase activator activity	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:10987289
Molecular Function	GO:0016176	superoxide-generating NADPH oxidase activator activity	Ncf1	IDA		Mouse	PMID:8119734
Molecular Function	GO:0016176	superoxide-generating NADPH oxidase activator activity	Ncf1	IDA		Rat	PMID:16040349|RGD:1600567
Cellular Component	GO:0005737	cytoplasm	Ncf1	IDA		Mouse	MGI:MGI:5825417|PMID:26021615
Cellular Component	GO:0005737	cytoplasm	Ncf1	IDA		Mouse	PMID:11156938
Cellular Component	GO:0005737	cytoplasm	Ncf1	IDA		Mouse	PMID:15850784
Cellular Component	GO:0005829	cytosol	NCF1	IDA		Human	PMID:2550933
Cellular Component	GO:0005829	cytosol	NCF1	IDA		Human	PMID:26514923
Cellular Component	GO:0005829	cytosol	NCF1	IDA		Human	PMID:8280052
Cellular Component	GO:0005829	cytosol	Ncf1	IDA		Rat	PMID:15718414|RGD:1600565
Cellular Component	GO:0005829	cytosol	Ncf1	IDA		Rat	PMID:17418121|RGD:2291897
Cellular Component	GO:0030425	dendrite	Ncf1	IDA		Rat	PMID:15804439|RGD:1600566
Cellular Component	GO:0030425	dendrite	Ncf1	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0030425	dendrite	Ncf1	IDA		Rat	PMID:17418121|RGD:2291897
Cellular Component	GO:0019898	extrinsic component of membrane	NCF1	IDA		Human	PMID:12356722
Cellular Component	GO:0005794	Golgi apparatus	Ncf1	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0016020	membrane	NCF1	IDA		Human	PMID:8280052
Cellular Component	GO:0016020	membrane	Ncf1	IDA		Mouse	MGI:MGI:5825417|PMID:26021615
Cellular Component	GO:0016020	membrane	Ncf1	IDA		Rat	PMID:15718414|RGD:1600565
Cellular Component	GO:0043020	NADPH oxidase complex	NCF1	IDA		Human	PMID:2550933
Cellular Component	GO:0043020	NADPH oxidase complex	NCF1	IDA		Human	PMID:8280052
Cellular Component	GO:0043020	NADPH oxidase complex	Ncf1	IDA		Rat	PMID:12241540|RGD:2291907
Cellular Component	GO:0043025	neuronal cell body	Ncf1	IDA		Rat	PMID:15804439|RGD:1600566
Cellular Component	GO:0043025	neuronal cell body	Ncf1	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0005886	plasma membrane	NCF1	IDA		Human	PMID:26514923
Cellular Component	GO:0005886	plasma membrane	Ncf1	IDA		Rat	PMID:17418121|RGD:2291897
Cellular Component	GO:0005791	rough endoplasmic reticulum	Ncf1	IDA		Rat	PMID:17027166|RGD:1599676
Biological Process	GO:0006915	apoptotic process	Ncf1	IMP		Rat	PMID:16344068|RGD:1600568
Biological Process	GO:0006968	cellular defense response	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:7650482
Biological Process	GO:0071276	cellular response to cadmium ion	NCF1	IDA		Human	PMID:26514923
Biological Process	GO:0071276	cellular response to cadmium ion	NCF1	IMP		Human	PMID:26514923
Biological Process	GO:0071333	cellular response to glucose stimulus	Ncf1	IEP		Rat	PMID:25512346|RGD:151708735
Biological Process	GO:0034614	cellular response to reactive oxygen species	NCF1	IDA		Human	PMID:26514923
Biological Process	GO:0071394	cellular response to testosterone stimulus	Ncf1	IEP		Rat	PMID:25512346|RGD:151708735
Biological Process	GO:0042742	defense response to bacterium	Ncf1	IMP	MGI:MGI:2661962	Mouse	PMID:17526748
Biological Process	GO:0042742	defense response to bacterium	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:9116268
Biological Process	GO:0050832	defense response to fungus	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:10714686
Biological Process	GO:0050832	defense response to fungus	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:16041040
Biological Process	GO:0050832	defense response to fungus	ncf1	IMP	ZFIN:ZDB-MRPHLNO-110804-1	Zfish	PMID:21551247
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:11907569
Biological Process	GO:0050673	epithelial cell proliferation	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:10987289
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:15258578
Biological Process	GO:0006954	inflammatory response	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:11867678
Biological Process	GO:0001909	leukocyte mediated cytotoxicity	Ncf1	IMP	MGI:MGI:2661962	Mouse	PMID:17526748
Biological Process	GO:0006691	leukotriene metabolic process	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:11867678
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:17993584
Biological Process	GO:0070947	neutrophil-mediated killing of fungus	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:11907569
Biological Process	GO:0070946	neutrophil-mediated killing of gram-positive bacterium	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:11907569
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NCF1	IMP		Human	PMID:26514923
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	NCF1	IMP		Human	PMID:26514923
Biological Process	GO:0046330	positive regulation of JNK cascade	NCF1	IMP		Human	PMID:26514923
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	NCF1	IMP		Human	PMID:26514923
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	NCF1	IMP		Human	PMID:26514923
Biological Process	GO:0006612	protein targeting to membrane	NCF1	IDA		Human	PMID:12356722
Biological Process	GO:1903409	reactive oxygen species biosynthetic process	Ncf1	IMP		Rat	PMID:21275845|RGD:41404729
Biological Process	GO:0060264	regulation of respiratory burst involved in inflammatory response	Ncf1	IMP		Rat	PMID:21275845|RGD:41404729
Biological Process	GO:0045730	respiratory burst	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:15626477
Biological Process	GO:0045730	respiratory burst	Ncf1	IMP		Rat	PMID:12461526|RGD:628543
Biological Process	GO:0045730	respiratory burst	ncf1	IMP	ZFIN:ZDB-MRPHLNO-110804-1	Zfish	PMID:21551247
Biological Process	GO:0045730	respiratory burst	ncf1	IMP	ZFIN:ZDB-MRPHLNO-110804-1,ZFIN:ZDB-MRPHLNO-110804-2	Zfish	PMID:21551247
Biological Process	GO:0045730	respiratory burst	ncf1	IMP	ZFIN:ZDB-MRPHLNO-110804-2	Zfish	PMID:21551247
Biological Process	GO:0002679	respiratory burst involved in defense response	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:10714686
Biological Process	GO:0009617	response to bacterium	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:10678931
Biological Process	GO:0001878	response to yeast	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:10714686
Biological Process	GO:0001878	response to yeast	Ncf1	IMP	MGI:MGI:3576788	Mouse	PMID:11907569
Biological Process	GO:0006939	smooth muscle contraction	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:17993584
Biological Process	GO:0042554	superoxide anion generation	NCF1	IMP		Human	PMID:2547247
Biological Process	GO:0042554	superoxide anion generation	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:11156938
Biological Process	GO:0042554	superoxide anion generation	Ncf1	IMP	MGI:MGI:1934143	Mouse	PMID:10725280

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern