Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NCL
  • Mouse genes Ncl
  • Rat genes Ncl
  • Zfish genes ncl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ncl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Ncl	IDA		Rat	PMID:11948683|RGD:727360
Molecular Function	GO:0044547	DNA topoisomerase binding	NCL	IPI	UniProtKB:P11387	Human	PMID:8567649
Molecular Function	GO:1990631	ErbB-4 class receptor binding	Ncl	IPI	RGD:620486	Rat	PMID:18523588|RGD:9686424
Molecular Function	GO:0042393	histone binding	Ncl	IDA		Rat	PMID:8424749|RGD:9686387
Molecular Function	GO:0042802	identical protein binding	NCL	IPI	UniProtKB:P19338	Human	PMID:21575138
Molecular Function	GO:0043560	insulin receptor substrate binding	Ncl	IPI	PR:P35569	Mouse	PMID:9813005
Molecular Function	GO:0043560	insulin receptor substrate binding	Ncl	IPI	PR:P81122	Mouse	PMID:9813005
Molecular Function	GO:0043236	laminin binding	Ncl	IDA		Rat	PMID:8583499|RGD:9686427
Molecular Function	GO:0048027	mRNA 5'-UTR binding	NCL	IDA		Human	PMID:16213212
Molecular Function	GO:0042731	PH domain binding	Ncl	IPI	PR:P81122	Mouse	PMID:9813005
Molecular Function	GO:0042731	PH domain binding	Ncl	IPI	PR:P35569	Mouse	PMID:9813005
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P21741	Human	PMID:12147681
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:12427757
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q9UQ80	Human	PMID:15064750
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P01106	Human	PMID:15674325
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P61254	Human	PMID:16213212
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P35579	Human	PMID:16403913
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P06748	Human	PMID:16648475
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P17480	Human	PMID:16777843
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q7Z2E3	Human	PMID:16777843
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P39060:PRO_0000005794	Human	PMID:17615292
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P32121	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P49407	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q9Y6D6	Human	PMID:18292223
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q8AZK7	Human	PMID:18457437
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q99697-2	Human	PMID:19174163
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q96BK5	Human	PMID:19393617
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q7Z333	Human	PMID:19515850
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P39060:PRO_0000005794	Human	PMID:19877579
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q00987	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q06710	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P11940	Human	PMID:20221403
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P26651	Human	PMID:20221403
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q15303	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q9BRS2	Human	PMID:21081503
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q00839	Human	PMID:21242313
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P61586	Human	PMID:21281639
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P04637	Human	PMID:22103682
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q00987	Human	PMID:22103682
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q6NS38	Human	PMID:23972994
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q9CR42	Human	PMID:24515436
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:Q06787	Human	PMID:24658146
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	NCL	IPI	UniProtKB:P51858-1	Human	PMID:26845719
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:Q9DC51	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:P63028	Mouse	MGI:MGI:4849323|PMID:21048921
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:Q9CR42	Mouse	MGI:MGI:5585395|PMID:24515436
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:P35922	Mouse	MGI:MGI:5767076|PMID:10567518
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:Q9QWV4	Mouse	MGI:MGI:2388865|PMID:12176995
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:Q64321	Mouse	MGI:MGI:5912851|PMID:28784777
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:Q9WVE0	Mouse	MGI:MGI:5004983|PMID:21518874
Molecular Function	GO:0005515	protein binding	Ncl	IPI	PR:P97953-4	Mouse	PMID:20415667
Molecular Function	GO:0005515	protein binding	Ncl	IPI	PR:Q91YK2	Mouse	PMID:19710015
Molecular Function	GO:0005515	protein binding	Ncl	IPI	RGD:3729	Rat	PMID:16854843|RGD:2313152
Molecular Function	GO:0005515	protein binding	Ncl	IPI	RGD:621808	Rat	PMID:16854843|RGD:2313152
Molecular Function	GO:0005515	protein binding	Ncl	IPI	UniProtKB:Q9R0N3	Rat	PMID:24882364|RGD:8693368
Molecular Function	GO:0003723	RNA binding	NCL	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	NCL	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	NCL	IDA		Human	PMID:8321232
Molecular Function	GO:0003723	RNA binding	Ncl	IDA		Mouse	PMID:17971306
Molecular Function	GO:0003723	RNA binding	Ncl	IDA		Rat	PMID:2049089|RGD:9588272
Molecular Function	GO:0042134	rRNA primary transcript binding	Ncl	IDA		Rat	PMID:3790520|RGD:9693697
Molecular Function	GO:0035368	selenocysteine insertion sequence binding	Ncl	IDA		Rat	PMID:20385601|RGD:5133727
Molecular Function	GO:0043565	sequence-specific DNA binding	Ncl	IDA		Rat	PMID:6311246|RGD:9693696
Molecular Function	GO:0005102	signaling receptor binding	Ncl	IDA		Rat	PMID:18523588|RGD:9686424
Molecular Function	GO:0003697	single-stranded DNA binding	Ncl	IDA		Rat	PMID:6311246|RGD:9693696
Molecular Function	GO:0042162	telomeric DNA binding	NCL	IDA		Human	PMID:8321232
Cellular Component	GO:0005938	cell cortex	NCL	IDA		Human	PMID:16403913
Cellular Component	GO:0009986	cell surface	Ncl	IDA		Rat	PMID:23912744|RGD:9686392
Cellular Component	GO:0005694	chromosome	NCL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001533	cornified envelope	Ncl	IDA		Mouse	PMID:26644517
Cellular Component	GO:0005737	cytoplasm	Ncl	IDA		Rat	PMID:9636677|RGD:9686425
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	NCL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	NCL	IDA		Human	PMID:15121898
Cellular Component	GO:0001651	dense fibrillar component	Ncl	IDA		Rat	PMID:6206987|RGD:9693699
Cellular Component	GO:0070062	extracellular exosome	NCL	HDA		Human	PMID:20458337
Cellular Component	GO:0001650	fibrillar center	Ncl	IDA		Rat	PMID:6206987|RGD:9693699
Cellular Component	GO:0016020	membrane	NCL	HDA		Human	PMID:19946888
Cellular Component	GO:0005730	nucleolus	NCL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	NCL	IDA		Human	PMID:12944467
Cellular Component	GO:0005730	nucleolus	NCL	IDA		Human	PMID:19393617
Cellular Component	GO:0005730	nucleolus	NCL	IDA		Human	PMID:24071584
Cellular Component	GO:0005730	nucleolus	Ncl	IDA		Mouse	PMID:17971306
Cellular Component	GO:0005730	nucleolus	Ncl	IDA		Mouse	PMID:2100262
Cellular Component	GO:0005730	nucleolus	Ncl	IDA		Mouse	PMID:14729462
Cellular Component	GO:0005730	nucleolus	Ncl	IDA		Mouse	PMID:15364958
Cellular Component	GO:0005730	nucleolus	Ncl	IDA		Mouse	PMID:23712942
Cellular Component	GO:0005730	nucleolus	Ncl	IDA		Rat	PMID:8424749|RGD:9686387
Cellular Component	GO:0005654	nucleoplasm	NCL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NCL	IDA		Human	PMID:23353999
Cellular Component	GO:0005654	nucleoplasm	Ncl	IDA		Mouse	PMID:17971306
Cellular Component	GO:0005634	nucleus	NCL	IDA		Human	PMID:15121898
Cellular Component	GO:0005634	nucleus	NCL	IDA		Human	PMID:24071584
Cellular Component	GO:0005634	nucleus	Ncl	IDA		Mouse	PMID:9102301
Cellular Component	GO:1990904	ribonucleoprotein complex	NCL	IDA		Human	PMID:17289661
Cellular Component	GO:1990904	ribonucleoprotein complex	NCL	IDA		Human	PMID:18809582
Biological Process	GO:0001525	angiogenesis	NCL	IDA		Human	PMID:16403913
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Ncl	IDA		Mouse	PMID:8702723
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Ncl	IEP		Mouse	PMID:20439489
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ncl	IMP		Rat	PMID:21309751|RGD:9686449
Biological Process	GO:0006897	endocytosis	Ncl	IMP		Rat	PMID:21309751|RGD:9686449
Biological Process	GO:0001947	heart looping	ncl	IMP	ZFIN:ZDB-MRPHLNO-140206-3	Zfish	PMID:24077883
Biological Process	GO:0097421	liver regeneration	Ncl	IEP		Rat	PMID:7490256|RGD:9686389
Biological Process	GO:0043066	negative regulation of apoptotic process	Ncl	IMP		Rat	PMID:20050922|RGD:9686380
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Ncl	IDA		Mouse	PMID:9813005
Biological Process	GO:0017148	negative regulation of translation	NCL	IMP		Human	PMID:16213212
Biological Process	GO:0001503	ossification	ncl	IMP	ZFIN:ZDB-GENO-230105-7	Zfish	PMID:35762670
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ncl	IMP		Rat	PMID:21309751|RGD:9686449
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ncl	IGI	MGI:MGI:1917202,MGI:MGI:97791,MGI:MGI:99894	Mouse	PMID:24530304
Biological Process	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	NCL	IMP		Human	PMID:24071584
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ncl	IMP		Rat	PMID:21309751|RGD:9686449
Biological Process	GO:0061035	regulation of cartilage development	ncl	IMP	ZFIN:ZDB-GENO-230105-7	Zfish	PMID:35762670
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	ncl	IMP	ZFIN:ZDB-GENO-230105-7	Zfish	PMID:35762670
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Ncl	IDA		Mouse	PMID:9813005
Biological Process	GO:2000232	regulation of rRNA processing	Ncl	IDA		Rat	PMID:2049089|RGD:9588272
Biological Process	GO:0006364	rRNA processing	ncl	IMP	ZFIN:ZDB-MRPHLNO-140206-3	Zfish	PMID:24077883
Biological Process	GO:0009303	rRNA transcription	ncl	IMP	ZFIN:ZDB-MRPHLNO-140206-3	Zfish	PMID:24077883
Biological Process	GO:0007283	spermatogenesis	Ncl	IEP		Rat	PMID:19570216|RGD:9686383

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern