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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ncstn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ncstn
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042500aspartic endopeptidase activity, intramembrane cleavingNcstnIGIMGI:MGI:1202717MousePMID:16371134
Molecular FunctionGO:0042500aspartic endopeptidase activity, intramembrane cleavingNcstnIGIMGI:MGI:3522097MousePMID:16371134
Molecular FunctionGO:0051117ATPase bindingNCSTNIPIUniProtKB:O75110HumanPMID:26094765
Molecular FunctionGO:0004175endopeptidase activityNcstnIMPMGI:MGI:2667524MousePMID:17913918
Molecular FunctionGO:0004175endopeptidase activityNcstnIDAMousePMID:19457123
Molecular FunctionGO:0070851growth factor receptor bindingNCSTNIPIUniProtKB:Q16620HumanPMID:26094765
Molecular FunctionGO:0008233peptidase activityNcstnIDARatPMID:12736250|RGD:724403
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49768HumanPMID:12297508
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49810HumanPMID:12297508
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q96BI3HumanPMID:12297508
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q9NZ42HumanPMID:15322109
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P35613HumanPMID:15890777
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49768:PRO_0000025592HumanPMID:15890777
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49755HumanPMID:16641999
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49768HumanPMID:16641999
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q9NZ42HumanPMID:16641999
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49768HumanPMID:18201567
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q96BI3HumanPMID:18201567
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q9NZ42HumanPMID:18201567
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q96BI3HumanPMID:19376115
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q96QE2HumanPMID:26094765
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:Q96BI3HumanPMID:26280335
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49768HumanPMID:29611543
Molecular FunctionGO:0005515protein bindingNCSTNIPIUniProtKB:P49768HumanPMID:30559186
Molecular FunctionGO:0005515protein bindingNcstnIPIUniProtKB:P14211MouseMGI:MGI:5553221|PMID:23585889
Molecular FunctionGO:0005515protein bindingNcstnIPIUniProtKB:Q9DBY1MouseMGI:MGI:5508580|PMID:19725872
Molecular FunctionGO:0005515protein bindingNcstnIPIPR:Q01853MousePMID:21600962
Molecular FunctionGO:0005515protein bindingNcstnIPIPR:Q61144MousePMID:15474363
Molecular FunctionGO:0005515protein bindingNcstnIPIPR:P49769MousePMID:21597003
Molecular FunctionGO:0005515protein bindingNcstnIPIPR:Q9JJK5MousePMID:21600962
Molecular FunctionGO:0005515protein bindingNcstnIPIPR:Q8BVF7MousePMID:15474363
Molecular FunctionGO:0005515protein bindingNcstnIPIPR:P49769MousePMID:15474363
Molecular FunctionGO:0005515protein bindingNcstnIPIRGD:3425RatPMID:15456764|RGD:1358417
Molecular FunctionGO:0005515protein bindingNcstnIPIRGD:1310013RatPMID:22535952|RGD:6484662
Molecular FunctionGO:0030674protein-macromolecule adaptor activityNCSTNIMPHumanPMID:12297508
Molecular FunctionGO:0030674protein-macromolecule adaptor activityNCSTNIGIUniProtKB:P05067|UniProtKB:P49768HumanPMID:12763021
Cellular ComponentGO:0005737cytoplasmNcstnIDARatPMID:16298244|RGD:13801190
Cellular ComponentGO:0005769early endosomeNcstnIDARatPMID:20126630|RGD:13702254
Cellular ComponentGO:0005783endoplasmic reticulumNCSTNIDAHumanPMID:15274632
Cellular ComponentGO:0005783endoplasmic reticulumNcstnIDAMousePMID:21187406
Cellular ComponentGO:0005783endoplasmic reticulumNcstnIDAMousePMID:12646573
Cellular ComponentGO:0070062extracellular exosomeNCSTNHDAHumanPMID:19056867
Cellular ComponentGO:0070062extracellular exosomeNCSTNHDAHumanPMID:20458337
Cellular ComponentGO:0005925focal adhesionNCSTNHDAHumanPMID:21423176
Cellular ComponentGO:0070765gamma-secretase complexNCSTNIPIHumanPMID:26280335
Cellular ComponentGO:0070765gamma-secretase complexNCSTNIDAHumanPMID:12297508
Cellular ComponentGO:0070765gamma-secretase complexNCSTNIGIUniProtKB:P05067|UniProtKB:P49768HumanPMID:12763021
Cellular ComponentGO:0070765gamma-secretase complexNCSTNIDAHumanPMID:25043039
Cellular ComponentGO:0070765gamma-secretase complexNCSTNIDAHumanPMID:26280335
Cellular ComponentGO:0070765gamma-secretase complexNcstnIDAMousePMID:16641999
Cellular ComponentGO:0070765gamma-secretase complexNcstnIDAMousePMID:20674680
Cellular ComponentGO:0070765gamma-secretase complexNcstnIDAMousePMID:16371134
Cellular ComponentGO:0005794Golgi apparatusNCSTNIDAHumanPMID:15274632
Cellular ComponentGO:0005794Golgi apparatusNcstnIDAMousePMID:12646573
Cellular ComponentGO:0005765lysosomal membraneNCSTNHDAHumanPMID:17897319
Cellular ComponentGO:0005765lysosomal membraneNcstnIDARatPMID:12736250|RGD:724403
Cellular ComponentGO:0005764lysosomeNcstnIDAMousePMID:25592972
Cellular ComponentGO:0016020membraneNCSTNHDAHumanPMID:19946888
Cellular ComponentGO:0016020membraneNCSTNIDAHumanPMID:25043039
Cellular ComponentGO:0016020membraneNCSTNIDAHumanPMID:26280335
Cellular ComponentGO:0016020membraneNcstnIDAMousePMID:11943765
Cellular ComponentGO:0016020membraneNcstnIDAMousePMID:15634781
Cellular ComponentGO:0016020membraneNcstnIDAMousePMID:15886206
Cellular ComponentGO:0005739mitochondrionNcstnIDARatPMID:15456764|RGD:1358417
Cellular ComponentGO:0005886plasma membraneNCSTNIDAHumanPMID:15274632
Cellular ComponentGO:0005886plasma membraneNcstnIDAMousePMID:21187406
Cellular ComponentGO:0005886plasma membraneNcstnIDAMousePMID:18201567
Cellular ComponentGO:0005886plasma membraneNcstnIDAMousePMID:12646573
Cellular ComponentGO:0005886plasma membraneNcstnIDARatPMID:20126630|RGD:13702254
Cellular ComponentGO:0042734presynaptic membraneNcstnIDARatPMID:20126630|RGD:13702254
Cellular ComponentGO:0032991protein-containing complexNcstnIDAMousePMID:21597003
Cellular ComponentGO:0032991protein-containing complexNcstnIDARatPMID:15456764|RGD:1358417
Cellular ComponentGO:0042383sarcolemmaNcstnIDARatPMID:16595164|RGD:1601507
Cellular ComponentGO:0045202synapseNcstnIDARatPMID:16298244|RGD:13801190
Cellular ComponentGO:0097060synaptic membraneNcstnIDARatPMID:20126630|RGD:13702254
Cellular ComponentGO:0008021synaptic vesicleNcstnIDAMousePMID:25438880
Cellular ComponentGO:0008021synaptic vesicleNcstnIDARatPMID:20126630|RGD:13702254
Biological ProcessGO:0030534adult behaviorNcstnIMPMGI:MGI:3796837MousePMID:27008863
Biological ProcessGO:0042983amyloid precursor protein biosynthetic processNcstnIMPMousePMID:18201567
Biological ProcessGO:0042987amyloid precursor protein catabolic processNCSTNIGIUniProtKB:P05067|UniProtKB:P49768HumanPMID:12763021
Biological ProcessGO:0042987amyloid precursor protein catabolic processNCSTNIDAHumanPMID:15274632
Biological ProcessGO:0042987amyloid precursor protein catabolic processNCSTNIDAHumanPMID:27608597
Biological ProcessGO:0042982amyloid precursor protein metabolic processNCSTNIDAHumanPMID:25043039
Biological ProcessGO:0042982amyloid precursor protein metabolic processNCSTNIDAHumanPMID:26280335
Biological ProcessGO:0042982amyloid precursor protein metabolic processNcstnIMPMousePMID:21597003
Biological ProcessGO:0034205amyloid-beta formationNCSTNIMPHumanPMID:12297508
Biological ProcessGO:0034205amyloid-beta formationNCSTNIGIUniProtKB:P05067|UniProtKB:P49768HumanPMID:12763021
Biological ProcessGO:0034205amyloid-beta formationNCSTNIMPHumanPMID:25043039
Biological ProcessGO:0034205amyloid-beta formationNCSTNIMPHumanPMID:26280335
Biological ProcessGO:0034205amyloid-beta formationNCSTNIDAHumanPMID:27608597
Biological ProcessGO:0034205amyloid-beta formationNcstnIGIMGI:MGI:1202717MousePMID:16371134
Biological ProcessGO:0034205amyloid-beta formationNcstnIGIMGI:MGI:3522097MousePMID:16371134
Biological ProcessGO:0050435amyloid-beta metabolic processNcstnIMPMGI:MGI:2667524MousePMID:17913918
Biological ProcessGO:0071277cellular response to calcium ionNcstnIMPMGI:MGI:3796837MousePMID:24889619
Biological ProcessGO:0022010central nervous system myelinationNcstnIMPMGI:MGI:3796837MousePMID:27008863
Biological ProcessGO:0021549cerebellum developmentNcstnIEPRatPMID:16298244|RGD:13801190
Biological ProcessGO:0007212dopamine receptor signaling pathwayNcstnIMPMGI:MGI:3796837MousePMID:27008863
Biological ProcessGO:0050673epithelial cell proliferationNcstnIMPMGI:MGI:2667524MousePMID:17913918
Biological ProcessGO:0050673epithelial cell proliferationNcstnIGIMGI:MGI:1202717MousePMID:17913918
Biological ProcessGO:0007215glutamate receptor signaling pathwayNcstnIMPMGI:MGI:3796837MousePMID:24889619
Biological ProcessGO:0007611learning or memoryNcstnIMPMGI:MGI:3796837MousePMID:19494151
Biological ProcessGO:0032438melanosome organizationncstnIMPZFIN:ZDB-GENO-210125-5ZfishPMID:31437444
Biological ProcessGO:0006509membrane protein ectodomain proteolysisNCSTNIDAHumanPMID:15274632
Biological ProcessGO:0031293membrane protein intracellular domain proteolysisNCSTNIDAHumanPMID:15274632
Biological ProcessGO:0002262myeloid cell homeostasisNcstnIMPMGI:MGI:2667524MousePMID:17913918
Biological ProcessGO:0051402neuron apoptotic processNcstnIMPMGI:MGI:3796837MousePMID:19494151
Biological ProcessGO:0007220Notch receptor processingNCSTNIMPHumanPMID:12297508
Biological ProcessGO:0007220Notch receptor processingNCSTNIDAHumanPMID:27608597
Biological ProcessGO:0042986positive regulation of amyloid precursor protein biosynthetic processNcstnIMPMousePMID:23826707
Biological ProcessGO:0043085positive regulation of catalytic activityNCSTNIDAHumanPMID:15274632
Biological ProcessGO:0010950positive regulation of endopeptidase activityNCSTNIMPHumanPMID:12297508
Biological ProcessGO:0010950positive regulation of endopeptidase activityNCSTNIGIUniProtKB:P05067|UniProtKB:P49768HumanPMID:12763021
Biological ProcessGO:0016485protein processingNCSTNIMPHumanPMID:12297508
Biological ProcessGO:0016485protein processingNCSTNIGIUniProtKB:P05067|UniProtKB:P49768HumanPMID:12763021
Biological ProcessGO:0016485protein processingNCSTNIDAHumanPMID:15274632
Biological ProcessGO:0016485protein processingNCSTNIDAHumanPMID:27608597
Biological ProcessGO:0016485protein processingNcstnIEPRatPMID:12736250|RGD:724403
Biological ProcessGO:1900271regulation of long-term synaptic potentiationNcstnIMPMGI:MGI:3796837MousePMID:24889619
Biological ProcessGO:1990926short-term synaptic potentiationNcstnIMPMGI:MGI:3796837MousePMID:24889619
Biological ProcessGO:0042098T cell proliferationNcstnIMPMGI:MGI:2667524MousePMID:17913918

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory