Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ncstn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NCSTN
- Mouse genes Ncstn
- Rat genes Ncstn
- Zfish genes ncstn
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ncstn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Ncstn	IGI	MGI:MGI:1202717	Mouse	PMID:16371134
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Ncstn	IGI	MGI:MGI:3522097	Mouse	PMID:16371134
Molecular Function	GO:0051117	ATPase binding	NCSTN	IPI	UniProtKB:O75110	Human	PMID:26094765
Molecular Function	GO:0004175	endopeptidase activity	Ncstn	IMP	MGI:MGI:2667524	Mouse	PMID:17913918
Molecular Function	GO:0004175	endopeptidase activity	Ncstn	IDA		Mouse	PMID:19457123
Molecular Function	GO:0070851	growth factor receptor binding	NCSTN	IPI	UniProtKB:Q16620	Human	PMID:26094765
Molecular Function	GO:0008233	peptidase activity	Ncstn	IDA		Rat	PMID:12736250\|RGD:724403
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49768	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49810	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q96BI3	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q9NZ42	Human	PMID:15322109
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P35613	Human	PMID:15890777
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49768:PRO_0000025592	Human	PMID:15890777
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49755	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49768	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q9NZ42	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49768	Human	PMID:18201567
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q96BI3	Human	PMID:18201567
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q9NZ42	Human	PMID:18201567
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q96BI3	Human	PMID:19376115
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q96QE2	Human	PMID:26094765
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:Q96BI3	Human	PMID:26280335
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49768	Human	PMID:29611543
Molecular Function	GO:0005515	protein binding	NCSTN	IPI	UniProtKB:P49768	Human	PMID:30559186
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	UniProtKB:P14211	Mouse	MGI:MGI:5553221\|PMID:23585889
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	UniProtKB:Q9DBY1	Mouse	MGI:MGI:5508580\|PMID:19725872
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	PR:Q01853	Mouse	PMID:21600962
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	PR:Q61144	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	PR:P49769	Mouse	PMID:21597003
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	PR:Q9JJK5	Mouse	PMID:21600962
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	PR:Q8BVF7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	PR:P49769	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	RGD:3425	Rat	PMID:15456764\|RGD:1358417
Molecular Function	GO:0005515	protein binding	Ncstn	IPI	RGD:1310013	Rat	PMID:22535952\|RGD:6484662
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	NCSTN	IMP		Human	PMID:12297508
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	NCSTN	IGI	UniProtKB:P05067\|UniProtKB:P49768	Human	PMID:12763021
Cellular Component	GO:0005737	cytoplasm	Ncstn	IDA		Rat	PMID:16298244\|RGD:13801190
Cellular Component	GO:0005769	early endosome	Ncstn	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0005783	endoplasmic reticulum	NCSTN	IDA		Human	PMID:15274632
Cellular Component	GO:0005783	endoplasmic reticulum	Ncstn	IDA		Mouse	PMID:21187406
Cellular Component	GO:0005783	endoplasmic reticulum	Ncstn	IDA		Mouse	PMID:12646573
Cellular Component	GO:0070062	extracellular exosome	NCSTN	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	NCSTN	HDA		Human	PMID:20458337
Cellular Component	GO:0005925	focal adhesion	NCSTN	HDA		Human	PMID:21423176
Cellular Component	GO:0070765	gamma-secretase complex	NCSTN	IPI		Human	PMID:26280335
Cellular Component	GO:0070765	gamma-secretase complex	NCSTN	IDA		Human	PMID:12297508
Cellular Component	GO:0070765	gamma-secretase complex	NCSTN	IGI	UniProtKB:P05067\|UniProtKB:P49768	Human	PMID:12763021
Cellular Component	GO:0070765	gamma-secretase complex	NCSTN	IDA		Human	PMID:25043039
Cellular Component	GO:0070765	gamma-secretase complex	NCSTN	IDA		Human	PMID:26280335
Cellular Component	GO:0070765	gamma-secretase complex	Ncstn	IDA		Mouse	PMID:16641999
Cellular Component	GO:0070765	gamma-secretase complex	Ncstn	IDA		Mouse	PMID:20674680
Cellular Component	GO:0070765	gamma-secretase complex	Ncstn	IDA		Mouse	PMID:16371134
Cellular Component	GO:0005794	Golgi apparatus	NCSTN	IDA		Human	PMID:15274632
Cellular Component	GO:0005794	Golgi apparatus	Ncstn	IDA		Mouse	PMID:12646573
Cellular Component	GO:0005765	lysosomal membrane	NCSTN	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	Ncstn	IDA		Rat	PMID:12736250\|RGD:724403
Cellular Component	GO:0005764	lysosome	Ncstn	IDA		Mouse	PMID:25592972
Cellular Component	GO:0016020	membrane	NCSTN	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	NCSTN	IDA		Human	PMID:25043039
Cellular Component	GO:0016020	membrane	NCSTN	IDA		Human	PMID:26280335
Cellular Component	GO:0016020	membrane	Ncstn	IDA		Mouse	PMID:11943765
Cellular Component	GO:0016020	membrane	Ncstn	IDA		Mouse	PMID:15634781
Cellular Component	GO:0016020	membrane	Ncstn	IDA		Mouse	PMID:15886206
Cellular Component	GO:0005739	mitochondrion	Ncstn	IDA		Rat	PMID:15456764\|RGD:1358417
Cellular Component	GO:0005886	plasma membrane	NCSTN	IDA		Human	PMID:15274632
Cellular Component	GO:0005886	plasma membrane	Ncstn	IDA		Mouse	PMID:21187406
Cellular Component	GO:0005886	plasma membrane	Ncstn	IDA		Mouse	PMID:18201567
Cellular Component	GO:0005886	plasma membrane	Ncstn	IDA		Mouse	PMID:12646573
Cellular Component	GO:0005886	plasma membrane	Ncstn	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0042734	presynaptic membrane	Ncstn	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0032991	protein-containing complex	Ncstn	IDA		Mouse	PMID:21597003
Cellular Component	GO:0032991	protein-containing complex	Ncstn	IDA		Rat	PMID:15456764\|RGD:1358417
Cellular Component	GO:0042383	sarcolemma	Ncstn	IDA		Rat	PMID:16595164\|RGD:1601507
Cellular Component	GO:0045202	synapse	Ncstn	IDA		Rat	PMID:16298244\|RGD:13801190
Cellular Component	GO:0097060	synaptic membrane	Ncstn	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0008021	synaptic vesicle	Ncstn	IDA		Mouse	PMID:25438880
Cellular Component	GO:0008021	synaptic vesicle	Ncstn	IDA		Rat	PMID:20126630\|RGD:13702254
Biological Process	GO:0030534	adult behavior	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:27008863
Biological Process	GO:0042983	amyloid precursor protein biosynthetic process	Ncstn	IMP		Mouse	PMID:18201567
Biological Process	GO:0042987	amyloid precursor protein catabolic process	NCSTN	IGI	UniProtKB:P05067\|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0042987	amyloid precursor protein catabolic process	NCSTN	IDA		Human	PMID:15274632
Biological Process	GO:0042987	amyloid precursor protein catabolic process	NCSTN	IDA		Human	PMID:27608597
Biological Process	GO:0042982	amyloid precursor protein metabolic process	NCSTN	IDA		Human	PMID:25043039
Biological Process	GO:0042982	amyloid precursor protein metabolic process	NCSTN	IDA		Human	PMID:26280335
Biological Process	GO:0042982	amyloid precursor protein metabolic process	Ncstn	IMP		Mouse	PMID:21597003
Biological Process	GO:0034205	amyloid-beta formation	NCSTN	IMP		Human	PMID:12297508
Biological Process	GO:0034205	amyloid-beta formation	NCSTN	IGI	UniProtKB:P05067\|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0034205	amyloid-beta formation	NCSTN	IMP		Human	PMID:25043039
Biological Process	GO:0034205	amyloid-beta formation	NCSTN	IMP		Human	PMID:26280335
Biological Process	GO:0034205	amyloid-beta formation	NCSTN	IDA		Human	PMID:27608597
Biological Process	GO:0034205	amyloid-beta formation	Ncstn	IGI	MGI:MGI:1202717	Mouse	PMID:16371134
Biological Process	GO:0034205	amyloid-beta formation	Ncstn	IGI	MGI:MGI:3522097	Mouse	PMID:16371134
Biological Process	GO:0050435	amyloid-beta metabolic process	Ncstn	IMP	MGI:MGI:2667524	Mouse	PMID:17913918
Biological Process	GO:0071277	cellular response to calcium ion	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:24889619
Biological Process	GO:0022010	central nervous system myelination	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:27008863
Biological Process	GO:0021549	cerebellum development	Ncstn	IEP		Rat	PMID:16298244\|RGD:13801190
Biological Process	GO:0007212	dopamine receptor signaling pathway	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:27008863
Biological Process	GO:0050673	epithelial cell proliferation	Ncstn	IMP	MGI:MGI:2667524	Mouse	PMID:17913918
Biological Process	GO:0050673	epithelial cell proliferation	Ncstn	IGI	MGI:MGI:1202717	Mouse	PMID:17913918
Biological Process	GO:0007215	glutamate receptor signaling pathway	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:24889619
Biological Process	GO:0007611	learning or memory	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:19494151
Biological Process	GO:0032438	melanosome organization	ncstn	IMP	ZFIN:ZDB-GENO-210125-5	Zfish	PMID:31437444
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	NCSTN	IDA		Human	PMID:15274632
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	NCSTN	IDA		Human	PMID:15274632
Biological Process	GO:0002262	myeloid cell homeostasis	Ncstn	IMP	MGI:MGI:2667524	Mouse	PMID:17913918
Biological Process	GO:0051402	neuron apoptotic process	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:19494151
Biological Process	GO:0007220	Notch receptor processing	NCSTN	IMP		Human	PMID:12297508
Biological Process	GO:0007220	Notch receptor processing	NCSTN	IDA		Human	PMID:27608597
Biological Process	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	Ncstn	IMP		Mouse	PMID:23826707
Biological Process	GO:0043085	positive regulation of catalytic activity	NCSTN	IDA		Human	PMID:15274632
Biological Process	GO:0010950	positive regulation of endopeptidase activity	NCSTN	IMP		Human	PMID:12297508
Biological Process	GO:0010950	positive regulation of endopeptidase activity	NCSTN	IGI	UniProtKB:P05067\|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0016485	protein processing	NCSTN	IMP		Human	PMID:12297508
Biological Process	GO:0016485	protein processing	NCSTN	IGI	UniProtKB:P05067\|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0016485	protein processing	NCSTN	IDA		Human	PMID:15274632
Biological Process	GO:0016485	protein processing	NCSTN	IDA		Human	PMID:27608597
Biological Process	GO:0016485	protein processing	Ncstn	IEP		Rat	PMID:12736250\|RGD:724403
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:24889619
Biological Process	GO:1990926	short-term synaptic potentiation	Ncstn	IMP	MGI:MGI:3796837	Mouse	PMID:24889619
Biological Process	GO:0042098	T cell proliferation	Ncstn	IMP	MGI:MGI:2667524	Mouse	PMID:17913918

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.