Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NDP
  • Mouse genes Ndp
  • Rat genes Ndp
  • Zfish genes ndp
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ndp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	NDP	IDA		Human	PMID:17955262
Molecular Function	GO:0005125	cytokine activity	Ndp	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Molecular Function	GO:0005109	frizzled binding	NDP	IPI	UniProtKB:Q9ULV1	Human	PMID:17955262
Molecular Function	GO:0005109	frizzled binding	Ndp	IPI	UniProtKB:Q61088	Mouse	MGI:MGI:3621833|PMID:15035989
Molecular Function	GO:0005515	protein binding	NDP	IPI	UniProtKB:Q9ULV1	Human	PMID:17955262
Molecular Function	GO:0005515	protein binding	NDP	IPI	UniProtKB:Q9ULV1	Human	PMID:19837033
Molecular Function	GO:0042803	protein homodimerization activity	NDP	IPI	UniProtKB:Q00604	Human	PMID:17955262
Cellular Component	GO:0009986	cell surface	NDP	IDA		Human	PMID:17955262
Cellular Component	GO:0062023	collagen-containing extracellular matrix	NDP	IDA		Human	PMID:15035989
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ndp	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Cellular Component	GO:0005615	extracellular space	NDP	IDA		Human	PMID:17955262
Biological Process	GO:0001508	action potential	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:9071226
Biological Process	GO:0001508	action potential	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:28575130
Biological Process	GO:0001525	angiogenesis	Ndp	IGI	MGI:MGI:108520	Mouse	PMID:27823583
Biological Process	GO:0001525	angiogenesis	Ndp	IMP	MGI:MGI:4414644	Mouse	PMID:27823583
Biological Process	GO:0001974	blood vessel remodeling	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:28575130
Biological Process	GO:0060070	canonical Wnt signaling pathway	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0060070	canonical Wnt signaling pathway	Ndp	IDA		Mouse	PMID:29715368
Biological Process	GO:0008283	cell population proliferation	Ndp	IDA		Mouse	PMID:15716406
Biological Process	GO:0008283	cell population proliferation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:15716406
Biological Process	GO:0008283	cell population proliferation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:22394677
Biological Process	GO:0008283	cell population proliferation	Ndp	IMP	MGI:MGI:4414644	Mouse	PMID:23201751
Biological Process	GO:0008283	cell population proliferation	Ndp	IDA		Mouse	PMID:23201751
Biological Process	GO:0008283	cell population proliferation	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:25414188
Biological Process	GO:0071456	cellular response to hypoxia	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30988181
Biological Process	GO:1904390	cone retinal bipolar cell differentiation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:9071226
Biological Process	GO:0046697	decidualization	Ndp	IEP		Rat	PMID:21899531|RGD:8694207
Biological Process	GO:0016358	dendrite development	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30936556
Biological Process	GO:0060996	dendritic spine development	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30936556
Biological Process	GO:0045446	endothelial cell differentiation	Ndp	IMP		Mouse	PMID:23217714
Biological Process	GO:0060856	establishment of blood-brain barrier	Ndp	IMP		Mouse	PMID:23217714
Biological Process	GO:0060856	establishment of blood-brain barrier	Ndp	IGI	MGI:MGI:98961	Mouse	PMID:30478038
Biological Process	GO:1990963	establishment of blood-retinal barrier	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:29654250
Biological Process	GO:0035640	exploration behavior	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30936556
Biological Process	GO:0035426	extracellular matrix-cell signaling	Ndp	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0010467	gene expression	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:22394677
Biological Process	GO:0010467	gene expression	Ndp	IDA		Mouse	PMID:23201751
Biological Process	GO:0010467	gene expression	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0010467	gene expression	Ndp	IDA		Mouse	PMID:29715368
Biological Process	GO:0010467	gene expression	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30988181
Biological Process	GO:0006749	glutathione metabolic process	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30988181
Biological Process	GO:0006544	glycine metabolic process	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30988181
Biological Process	GO:0006954	inflammatory response	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:29654250
Biological Process	GO:0002088	lens development in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:15716406
Biological Process	GO:0002088	lens development in camera-type eye	Ndp	IDA		Mouse	PMID:15716406
Biological Process	GO:0014004	microglia differentiation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:29654250
Biological Process	GO:0061518	microglial cell proliferation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:29654250
Biological Process	GO:0000278	mitotic cell cycle	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:22394677
Biological Process	GO:0003407	neural retina development	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:15716406
Biological Process	GO:0003407	neural retina development	Ndp	IDA		Mouse	PMID:15716406
Biological Process	GO:0051402	neuron apoptotic process	Ndp	IDA		Mouse	PMID:29715368
Biological Process	GO:0030182	neuron differentiation	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30936556
Biological Process	GO:0110135	Norrin signaling pathway	NDP	IDA		Human	PMID:15035989
Biological Process	GO:0110135	Norrin signaling pathway	NDP	IDA		Human	PMID:17955262
Biological Process	GO:0110135	Norrin signaling pathway	Ndp	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0021554	optic nerve development	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0001890	placenta development	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:16035034
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Ndp	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NDP	IDA		Human	PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NDP	IDA		Human	PMID:17955262
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ndp	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0043491	protein kinase B signaling	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0008104	protein localization	Ndp	IMP		Mouse	PMID:23217714
Biological Process	GO:0006468	protein phosphorylation	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0006622	protein targeting to lysosome	Ndp	IMP		Mouse	PMID:28675177
Biological Process	GO:0016567	protein ubiquitination	Ndp	IMP		Mouse	PMID:28675177
Biological Process	GO:0000320	re-entry into mitotic cell cycle	Ndp	IDA		Mouse	PMID:23201751
Biological Process	GO:0048678	response to axon injury	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0001666	response to hypoxia	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:25414188
Biological Process	GO:0097601	retina blood vessel maintenance	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:28575130
Biological Process	GO:0060041	retina development in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:9071226
Biological Process	GO:0010842	retina layer formation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:29654250
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:15716406
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	Ndp	IDA		Mouse	PMID:15716406
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IDA		Mouse	PMID:15716406
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:15716406
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:18978344
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP		Mouse	PMID:23217714
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:25083995
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:25414188
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:28575130
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IDA		Mouse	PMID:29715368
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:29654250
Biological Process	GO:0061298	retina vasculature development in camera-type eye	ndp	IMP	ZFIN:ZDB-MRPHLNO-160510-5	Zfish	PMID:26908610
Biological Process	GO:0061298	retina vasculature development in camera-type eye	ndp	IGI	ZFIN:ZDB-MRPHLNO-160510-3,ZFIN:ZDB-MRPHLNO-160510-5	Zfish	PMID:26908610
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:18978344
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Ndp	IGI	MGI:MGI:108520	Mouse	PMID:19837032
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Ndp	IGI	MGI:MGI:1278315	Mouse	PMID:19837032
Biological Process	GO:0061304	retinal blood vessel morphogenesis	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:18978344
Biological Process	GO:0061304	retinal blood vessel morphogenesis	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:22394677
Biological Process	GO:0061304	retinal blood vessel morphogenesis	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:28575130
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Ndp	IDA		Mouse	PMID:29079753
Biological Process	GO:0003406	retinal pigment epithelium development	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:9071226
Biological Process	GO:0060221	retinal rod cell differentiation	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:9071226
Biological Process	GO:0009069	serine family amino acid metabolic process	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30988181
Biological Process	GO:0007224	smoothened signaling pathway	Ndp	IDA		Mouse	PMID:23201751
Biological Process	GO:0006366	transcription by RNA polymerase II	Ndp	IMP	MGI:MGI:2676199	Mouse	PMID:18978344
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Ndp	IDA		Mouse	PMID:29715368
Biological Process	GO:0006099	tricarboxylic acid cycle	Ndp	IMP	MGI:MGI:4414794	Mouse	PMID:30988181
Biological Process	GO:0070086	ubiquitin-dependent endocytosis	Ndp	IMP		Mouse	PMID:28675177

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern