Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NDRG4
  • Mouse genes Ndrg4
  • Rat genes Ndrg4
  • Zfish genes ndrg4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ndrg4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NDRG4	IPI	UniProtKB:Q15041	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NDRG4	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NDRG4	IPI	UniProtKB:Q96DZ9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NDRG4	IPI	UniProtKB:Q9UI14	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Ndrg4	IPI	UniProtKB:Q9ES83	Mouse	MGI:MGI:5613454|PMID:24048452
Cellular Component	GO:0016323	basolateral plasma membrane	NDRG4	IDA		Human	PMID:19535783
Cellular Component	GO:0031253	cell projection membrane	Ndrg4	IDA		Mouse	MGI:MGI:5613454|PMID:24048452
Cellular Component	GO:0005737	cytoplasm	NDRG4	IDA		Human	PMID:12755708
Cellular Component	GO:0005737	cytoplasm	Ndrg4	IDA		Mouse	MGI:MGI:3776188|PMID:17998568
Cellular Component	GO:0005737	cytoplasm	Ndrg4	IDA		Mouse	MGI:MGI:5613454|PMID:24048452
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Ndrg4	IDA		Rat	PMID:11978392|RGD:1304242
Cellular Component	GO:0005739	mitochondrion	Ndrg4	IDA		Rat	PMID:11978392|RGD:1304242
Biological Process	GO:0007420	brain development	Ndrg4	IEP		Rat	PMID:11978392|RGD:1304242
Biological Process	GO:0060038	cardiac muscle cell proliferation	ndrg4	IMP	ZFIN:ZDB-MRPHLNO-080813-2	Zfish	PMID:18407257
Biological Process	GO:0060973	cell migration involved in heart development	Ndrg4	IMP		Mouse	MGI:MGI:5613454|PMID:24048452
Biological Process	GO:0045162	clustering of voltage-gated sodium channels	ndrg4	IMP	ZFIN:ZDB-CRISPR-170310-4	Zfish	PMID:27902705
Biological Process	GO:0045162	clustering of voltage-gated sodium channels	ndrg4	IMP	ZFIN:ZDB-MRPHLNO-080813-2	Zfish	PMID:27902705
Biological Process	GO:0035050	embryonic heart tube development	ndrg4	IMP	ZFIN:ZDB-MRPHLNO-080813-2	Zfish	PMID:18407257
Biological Process	GO:0001947	heart looping	ndrg4	IMP	ZFIN:ZDB-MRPHLNO-080813-2	Zfish	PMID:18407257
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	NDRG4	IDA		Human	PMID:12755708
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	NDRG4	IDA		Human	PMID:12755708
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	NDRG4	IDA		Human	PMID:12755708
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	NDRG4	IDA		Human	PMID:12755708
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ndrg4	IDA		Rat	PMID:16408304|RGD:10047195
Biological Process	GO:0010976	positive regulation of neuron projection development	Ndrg4	IMP		Rat	PMID:11978393|RGD:1304243
Biological Process	GO:2001135	regulation of endocytic recycling	Ndrg4	IMP		Mouse	MGI:MGI:5613454|PMID:24048452
Biological Process	GO:0048278	vesicle docking	Ndrg4	IMP		Mouse	MGI:MGI:5613454|PMID:24048452
Biological Process	GO:0008542	visual learning	Ndrg4	IMP		Mouse	MGI:MGI:5286035|PMID:21636852

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern