Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NECTIN2
  • Mouse genes Nectin2
  • Rat genes Nectin2
  • Zfish genes pvrl2l,si:ch73-22o12.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nectin2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	NECTIN2	IPI	UniProtKB:Q15762	Human	PMID:12913096
Molecular Function	GO:0050839	cell adhesion molecule binding	NECTIN2	IPI	UniProtKB:Q92692	Human	PMID:9845526
Molecular Function	GO:0050839	cell adhesion molecule binding	Nectin2	IPI	UniProtKB:Q9QZQ1	Mouse	MGI:MGI:3828417|PMID:10225955
Molecular Function	GO:0042802	identical protein binding	NECTIN2	IPI	UniProtKB:Q92692	Human	PMID:21982860
Molecular Function	GO:0042802	identical protein binding	NECTIN2	IPI	UniProtKB:Q92692	Human	PMID:22902367
Molecular Function	GO:0042802	identical protein binding	NECTIN2	IPI	UniProtKB:Q92692	Human	PMID:22927415
Molecular Function	GO:0042802	identical protein binding	NECTIN2	IPI	UniProtKB:Q92692	Human	PMID:23758976
Molecular Function	GO:0042802	identical protein binding	NECTIN2	IPI	UniProtKB:Q92692	Human	PMID:28515320
Molecular Function	GO:0042802	identical protein binding	Nectin2	IPI	UniProtKB:P32507-2	Mouse	MGI:MGI:5918221|PMID:22902367
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q99750	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q495A1	Human	PMID:19011627
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q15762	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q495A1	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q9NQS3	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q9NQS3-1	Human	PMID:22902367
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:P55196	Human	PMID:23750010
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q9NQS3	Human	PMID:23758976
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:P60370	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q8IUQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q15762	Human	PMID:26755705
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q6DKI7	Human	PMID:26755705
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q495A1	Human	PMID:27978489
Molecular Function	GO:0005515	protein binding	NECTIN2	IPI	UniProtKB:Q495A1	Human	PMID:28515320
Molecular Function	GO:0005515	protein binding	Nectin2	IPI	UniProtKB:A0A1B0GS01	Mouse	MGI:MGI:5908517|PMID:26755705
Molecular Function	GO:0005515	protein binding	Nectin2	IPI	PR:Q9JLB9	Mouse	PMID:12759359
Molecular Function	GO:0005515	protein binding	Nectin2	IPI	PR:Q8K4F0	Mouse	PMID:15752754
Molecular Function	GO:0005515	protein binding	pvrl2l	IPI	UniProtKB:A1L2D6	Zfish	PMID:20802085|ZFIN:ZDB-PUB-100910-6
Molecular Function	GO:0042803	protein homodimerization activity	Nectin2	IDA		Mouse	MGI:MGI:2675176|PMID:12826663
Cellular Component	GO:0043296	apical junction complex	Nectin2	IDA		Mouse	PMID:22512338
Cellular Component	GO:0009986	cell surface	NECTIN2	IDA		Human	PMID:16831868
Cellular Component	GO:0044291	cell-cell contact zone	Nectin2	IDA		Mouse	PMID:23533177
Cellular Component	GO:0005911	cell-cell junction	NECTIN2	IDA		Human	PMID:9845526
Cellular Component	GO:0005911	cell-cell junction	Nectin2	IDA		Mouse	PMID:15728677
Cellular Component	GO:0005911	cell-cell junction	Nectin2	IDA		Mouse	PMID:15660130
Cellular Component	GO:0070062	extracellular exosome	NECTIN2	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	NECTIN2	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	NECTIN2	IDA		Human	PMID:12913096
Cellular Component	GO:0005886	plasma membrane	Nectin2	IDA		Mouse	MGI:MGI:2675176|PMID:12826663
Cellular Component	GO:0005915	zonula adherens	Nectin2	IDA		Mouse	MGI:MGI:3828417|PMID:10225955
Biological Process	GO:0001675	acrosome assembly	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0044406	adhesion of symbiont to host	NECTIN2	IDA		Human	PMID:12915581
Biological Process	GO:0032990	cell part morphogenesis	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0044782	cilium organization	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0046814	coreceptor-mediated virion attachment to host cell	NECTIN2	IDA		Human	PMID:12915581
Biological Process	GO:0007010	cytoskeleton organization	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0051649	establishment of localization in cell	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0051654	establishment of mitochondrion localization	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0009566	fertilization	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0019064	fusion of virus membrane with host plasma membrane	NECTIN2	IDA		Human	PMID:12915581
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	NECTIN2	IDA		Human	PMID:9845526
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Nectin2	IDA		Mouse	MGI:MGI:2675176|PMID:12826663
Biological Process	GO:0002891	positive regulation of immunoglobulin mediated immune response	NECTIN2	IMP		Human	PMID:16831868
Biological Process	GO:0033005	positive regulation of mast cell activation	NECTIN2	IMP		Human	PMID:16831868
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	NECTIN2	IMP		Human	PMID:16304049
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	NECTIN2	IMP		Human	PMID:12913096
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	NECTIN2	IDA		Human	PMID:26755705
Biological Process	GO:0046596	regulation of viral entry into host cell	NECTIN2	IDA		Human	PMID:11602758
Biological Process	GO:0030382	sperm mitochondrion organization	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0007286	spermatid development	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0007289	spermatid nucleus differentiation	Nectin2	IMP	MGI:MGI:2183405	Mouse	PMID:10733589
Biological Process	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity	NECTIN2	IMP		Human	PMID:12913096
Biological Process	GO:0060370	susceptibility to T cell mediated cytotoxicity	NECTIN2	IDA		Human	PMID:15039383

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern