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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nedd4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nedd4
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0031698beta-2 adrenergic receptor bindingNEDD4IDAHumanPMID:18544533
Molecular FunctionGO:0019899enzyme bindingNEDD4IPIUniProtKB:P08183HumanPMID:26006083
Molecular FunctionGO:0035255ionotropic glutamate receptor bindingNedd4IDAMouseMGI:MGI:5763359|PMID:25505317
Molecular FunctionGO:0140677molecular function activator activityNEDD4IDAHumanPMID:34880843
Molecular FunctionGO:0050815phosphoserine residue bindingNedd4IDAMouseMGI:MGI:3813439|PMID:10037602
Molecular FunctionGO:0050816phosphothreonine residue bindingNedd4IDAMouseMGI:MGI:3813439|PMID:10037602
Molecular FunctionGO:0070064proline-rich region bindingNEDD4IPIUniProtKB:Q15038HumanPMID:11342538
Molecular FunctionGO:0070064proline-rich region bindingNEDD4IMPHumanPMID:15126635
Molecular FunctionGO:0070064proline-rich region bindingNedd4IPIPR:Q8R0W6MousePMID:11748237
Molecular FunctionGO:0070064proline-rich region bindingNedd4IPIUniProtKB:Q16621MousePMID:9305852
Molecular FunctionGO:0070064proline-rich region bindingNedd4IPIPR:P97764MousePMID:9305852
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P37088HumanPMID:10642508
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P51168HumanPMID:10642508
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P51170HumanPMID:10642508
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P37088HumanPMID:11359767
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P51168HumanPMID:11359767
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9Y4G8HumanPMID:11598133
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9NV92HumanPMID:12796489
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9Y3C5HumanPMID:15231748
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q99732HumanPMID:16118794
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q13571HumanPMID:17116753
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P0CG47HumanPMID:17719543
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P05161HumanPMID:18305167
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P60484HumanPMID:19345329
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:O54967HumanPMID:20086093
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P10114HumanPMID:20159449
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9UKE5HumanPMID:20159449
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:O95166HumanPMID:20562859
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P60520HumanPMID:20562859
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9GZQ8HumanPMID:20562859
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9H0R8HumanPMID:20562859
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9Y3C5HumanPMID:20676133
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P11362HumanPMID:21765395
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P51168HumanPMID:21765395
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q15012|UniProtKB:Q86VI4HumanPMID:22096579
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P07550HumanPMID:23166351
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q96B67HumanPMID:23208550
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q96B67HumanPMID:23236378
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P37088HumanPMID:23665454
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q07912HumanPMID:23686771
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9BZD6HumanPMID:23873930
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P0CG47HumanPMID:24981860
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q86VI4HumanPMID:25588945
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q86YD5HumanPMID:26854353
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q99732HumanPMID:27927196
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P00533HumanPMID:29455656
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:O15417HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P54259HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q14686HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q14934HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q6GQQ9HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q8IV31HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q8N4L1HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q96B67HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q96PN7HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q99732HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9BZD6HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9GZQ8HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9H305HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9UKN5HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q9Y3C5HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:Q16621HumanPMID:9305852
Molecular FunctionGO:0005515protein bindingNEDD4IPIUniProtKB:P68036HumanPMID:9990509
Molecular FunctionGO:0005515protein bindingNedd4IPIUniProtKB:Q64321MouseMGI:MGI:5912851|PMID:28784777
Molecular FunctionGO:0005515protein bindingNedd4IPIUniProtKB:Q60760MouseMGI:MGI:1342855|PMID:10446181
Molecular FunctionGO:0005515protein bindingNedd4IPIUniProtKB:P83510|UniProtKB:Q80ZJ1MouseMGI:MGI:4835109|PMID:20159449
Molecular FunctionGO:0005515protein bindingNedd4IPIUniProtKB:Q13322MouseMGI:MGI:4441129|PMID:15060076
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q99MK8MousePMID:17544362
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q9EQG5MousePMID:11042109
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q9WU38MousePMID:17544362
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q7TNC6MousePMID:22768111
Molecular FunctionGO:0005515protein bindingNedd4IPIMGI:MGI:2684414MousePMID:11717310
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:P70175MousePMID:21920314
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q6A037MousePMID:11717310
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q8C7U1MousePMID:11717310
Molecular FunctionGO:0005515protein bindingNedd4IPIPR:Q8R0W6MousePMID:11042109
Molecular FunctionGO:0005515protein bindingNedd4IPIRGD:3640RatPMID:11527431|RGD:1642065
Molecular FunctionGO:0005515protein bindingNedd4IPIRGD:3641RatPMID:11527431|RGD:1642065
Molecular FunctionGO:0005515protein bindingNedd4IPIRGD:3639|RGD:3640|RGD:3641RatPMID:8665844|RGD:633483
Molecular FunctionGO:0019904protein domain specific bindingNEDD4IPIUniProtKB:Q969W9HumanPMID:12907594
Molecular FunctionGO:0070063RNA polymerase bindingNEDD4IPIUniProtKB:P24928HumanPMID:17996703
Molecular FunctionGO:0019871sodium channel inhibitor activityNEDD4IDAHumanPMID:10642508
Molecular FunctionGO:0019871sodium channel inhibitor activityNedd4IDAMousePMID:10212229
Molecular FunctionGO:0043130ubiquitin bindingNEDD4IDAHumanPMID:9990509
Molecular FunctionGO:0061630ubiquitin protein ligase activityNEDD4IDAHumanPMID:11342538
Molecular FunctionGO:0061630ubiquitin protein ligase activityNEDD4IDAHumanPMID:17116753
Molecular FunctionGO:0061630ubiquitin protein ligase activityNEDD4IDAHumanPMID:17996703
Molecular FunctionGO:0061630ubiquitin protein ligase activityNEDD4IDAHumanPMID:20086093
Molecular FunctionGO:0061630ubiquitin protein ligase activityNEDD4IDAHumanPMID:26006083
Molecular FunctionGO:0061630ubiquitin protein ligase activityNEDD4IDAHumanPMID:34880843
Molecular FunctionGO:0061630ubiquitin protein ligase activityNedd4IDAMousePMID:11717310
Molecular FunctionGO:0061630ubiquitin protein ligase activityNedd4IDAMousePMID:9182527
Molecular FunctionGO:0004842ubiquitin-protein transferase activityNedd4IDARatPMID:20159449|RGD:8554407
Cellular ComponentGO:0005938cell cortexNEDD4IDAHumanPMID:9990509
Cellular ComponentGO:0000785chromatinNEDD4IDAHumanPMID:17996703
Cellular ComponentGO:0005737cytoplasmNEDD4IDAHumanPMID:11342538
Cellular ComponentGO:0005737cytoplasmNEDD4IDAHumanPMID:12796489
Cellular ComponentGO:0005737cytoplasmNedd4IDAMousePMID:14973438
Cellular ComponentGO:0005829cytosolNedd4IDAMousePMID:9182527
Cellular ComponentGO:0005829cytosolNedd4IDAMousePMID:19794060
Cellular ComponentGO:0043197dendritic spineNedd4IDAMouseMGI:MGI:5763359|PMID:25505317
Cellular ComponentGO:0070062extracellular exosomeNEDD4HDAHumanPMID:23533145
Cellular ComponentGO:0098978glutamatergic synapseNedd4IDAMousePMID:25505317
Cellular ComponentGO:0098978glutamatergic synapseNedd4IMPMousePMID:25505317
Cellular ComponentGO:0098978glutamatergic synapseNedd4IDARatPMID:21148011|RGD:13702142
Cellular ComponentGO:0098978glutamatergic synapseNedd4IMPRatPMID:21148011|RGD:13702142
Cellular ComponentGO:0005794Golgi apparatusNEDD4IDAHumanPMID:16118794
Cellular ComponentGO:0016020membraneNedd4IDAMousePMID:14973438
Cellular ComponentGO:0045121membrane raftNedd4IDARatPMID:11248052|RGD:1642066
Cellular ComponentGO:0005902microvillusNedd4IDARatPMID:9227416|RGD:1642067
Cellular ComponentGO:0005634nucleusNEDD4IDAHumanPMID:11342538
Cellular ComponentGO:0048471perinuclear region of cytoplasmNEDD4IDAHumanPMID:9990509
Cellular ComponentGO:0005886plasma membraneNEDD4IMPHumanPMID:15126635
Cellular ComponentGO:0005886plasma membraneNEDD4IDAHumanPMID:16118794
Cellular ComponentGO:0099524postsynaptic cytosolNedd4IMPMousePMID:25505317
Cellular ComponentGO:0099524postsynaptic cytosolNedd4IDAMousePMID:25505317
Cellular ComponentGO:0032991protein-containing complexNEDD4IDAHumanPMID:17116753
Cellular ComponentGO:0000151ubiquitin ligase complexNedd4IPIUniProtKB:Q9QYK7MousePMID:11042109
Biological ProcessGO:0002250adaptive immune responseNedd4IMPMGI:MGI:3829272MousePMID:18931680
Biological ProcessGO:0048514blood vessel morphogenesisNedd4IGIMGI:MGI:98737MousePMID:20026598
Biological ProcessGO:0048514blood vessel morphogenesisNedd4IMPMGI:MGI:3799317MousePMID:20026598
Biological ProcessGO:0034644cellular response to UVNEDD4IMPHumanPMID:17996703
Biological ProcessGO:0003197endocardial cushion developmentNedd4IGIMGI:MGI:98737MousePMID:20026598
Biological ProcessGO:0003197endocardial cushion developmentNedd4IMPMGI:MGI:3799317MousePMID:20026598
Biological ProcessGO:0098508endothelial to hematopoietic transitionnedd4aIMPZFIN:ZDB-MRPHLNO-170330-7ZfishPMID:26358189
Biological ProcessGO:0098508endothelial to hematopoietic transitionnedd4aIGIZFIN:ZDB-GENE-070615-28ZfishPMID:26358189
Biological ProcessGO:0051649establishment of localization in cellNedd4IDAMousePMID:10212229
Biological ProcessGO:0044111formation of structure involved in a symbiotic processNEDD4IMPHumanPMID:15126635
Biological ProcessGO:0042921glucocorticoid receptor signaling pathwayNEDD4IDAHumanPMID:8649367
Biological ProcessGO:0006955immune responseNedd4IEPRatPMID:11248052|RGD:1642066
Biological ProcessGO:0045087innate immune responseNEDD4IDAHumanPMID:23951545
Biological ProcessGO:0007041lysosomal transportNEDD4IDAHumanPMID:18544533
Biological ProcessGO:0045746negative regulation of Notch signaling pathwaynedd4aIMPZFIN:ZDB-MRPHLNO-170330-7ZfishPMID:26358189
Biological ProcessGO:2000650negative regulation of sodium ion transmembrane transporter activityNEDD4IDAHumanPMID:10642508
Biological ProcessGO:0010766negative regulation of sodium ion transportNEDD4IDAHumanPMID:10642508
Biological ProcessGO:0010766negative regulation of sodium ion transportNedd4IDAMousePMID:10212229
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IINedd4IMPMGI:MGI:3799317MousePMID:20026598
Biological ProcessGO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathwayNedd4IDAMouseMGI:MGI:4441129|PMID:15060076
Biological ProcessGO:0007528neuromuscular junction developmentNedd4IMPMGI:MGI:3529811MousePMID:19345204
Biological ProcessGO:0031175neuron projection developmentNEDD4IEPHumanPMID:9990509
Biological ProcessGO:0003151outflow tract morphogenesisNedd4IGIMGI:MGI:98737MousePMID:20026598
Biological ProcessGO:0003151outflow tract morphogenesisNedd4IMPMGI:MGI:3799317MousePMID:20026598
Biological ProcessGO:0046824positive regulation of nucleocytoplasmic transportNEDD4IDAHumanPMID:17218261
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingNEDD4IMPHumanPMID:17218260
Biological ProcessGO:0045732positive regulation of protein catabolic processNEDD4IDAHumanPMID:14973438
Biological ProcessGO:0045732positive regulation of protein catabolic processNedd4IDAMousePMID:11748237
Biological ProcessGO:0050847progesterone receptor signaling pathwayNEDD4IDAHumanPMID:8649367
Biological ProcessGO:0070534protein K63-linked ubiquitinationNedd4IDARatPMID:20159449|RGD:8554407
Biological ProcessGO:0006513protein monoubiquitinationNedd4IDAMousePMID:21920314
Biological ProcessGO:0006622protein targeting to lysosomeNEDD4IPIUniProtKB:Q9NZ52HumanPMID:17116753
Biological ProcessGO:0016567protein ubiquitinationNEDD4IDAHumanPMID:26280536
Biological ProcessGO:0016567protein ubiquitinationNEDD4IDAHumanPMID:17116753
Biological ProcessGO:0016567protein ubiquitinationNEDD4IDAHumanPMID:17996703
Biological ProcessGO:0016567protein ubiquitinationNEDD4IDAHumanPMID:18305167
Biological ProcessGO:0016567protein ubiquitinationNEDD4IDAHumanPMID:25631046
Biological ProcessGO:0016567protein ubiquitinationNedd4IDAMousePMID:9182527
Biological ProcessGO:0032801receptor catabolic processNEDD4IDAHumanPMID:18544533
Biological ProcessGO:0031623receptor internalizationNEDD4IDAHumanPMID:18544533
Biological ProcessGO:0048814regulation of dendrite morphogenesisNedd4IMPMouseMGI:MGI:4835109|PMID:20159449
Biological ProcessGO:0048814regulation of dendrite morphogenesisNedd4IDARatPMID:20159449|RGD:8554407
Biological ProcessGO:0042391regulation of membrane potentialNEDD4IDAHumanPMID:17289006
Biological ProcessGO:0034765regulation of monoatomic ion transmembrane transportNEDD4IDAHumanPMID:17289006
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationNedd4IDARatPMID:21148011|RGD:13702142
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationNedd4IEPRatPMID:21148011|RGD:13702142
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationNedd4IMPRatPMID:21148011|RGD:13702142
Biological ProcessGO:1901016regulation of potassium ion transmembrane transporter activityNEDD4IDAHumanPMID:17289006
Biological ProcessGO:0099576regulation of protein catabolic process at postsynapse, modulating synaptic transmissionNedd4IDARatPMID:21148011|RGD:13702142
Biological ProcessGO:0099576regulation of protein catabolic process at postsynapse, modulating synaptic transmissionNedd4IEPRatPMID:21148011|RGD:13702142
Biological ProcessGO:0099576regulation of protein catabolic process at postsynapse, modulating synaptic transmissionNedd4IMPRatPMID:21148011|RGD:13702142
Biological ProcessGO:0050807regulation of synapse organizationNedd4IMPMGI:MGI:3529811MousePMID:19345204
Biological ProcessGO:0140252regulation protein catabolic process at postsynapseNedd4IDARatPMID:21148011|RGD:13702142
Biological ProcessGO:0140252regulation protein catabolic process at postsynapseNedd4IEPRatPMID:21148011|RGD:13702142
Biological ProcessGO:0140252regulation protein catabolic process at postsynapseNedd4IMPRatPMID:21148011|RGD:13702142
Biological ProcessGO:0014894response to denervation involved in regulation of muscle adaptationNedd4IEPRatPMID:19125695|RGD:7242174
Biological ProcessGO:0006814sodium ion transportNedd4IDAMousePMID:10212229
Biological ProcessGO:0042110T cell activationNedd4IMPMGI:MGI:3829272MousePMID:18931680
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processNEDD4IDAHumanPMID:11342538
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processNEDD4IMPHumanPMID:17218260
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processNEDD4IMPHumanPMID:17996703
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processNEDD4IDAHumanPMID:20086093
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processNEDD4IDAHumanPMID:26263374
Biological ProcessGO:0006511ubiquitin-dependent protein catabolic processNedd4IMPMGI:MGI:3829272MousePMID:18931680
Biological ProcessGO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayNEDD4IMPHumanPMID:20086093
Biological ProcessGO:0046755viral buddingNEDD4IMPHumanPMID:15126635

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory