Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEDD4L
  • Mouse genes Nedd4l
  • Rat genes Nedd4l
  • Zfish genes nedd4l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nedd4l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019870	potassium channel inhibitor activity	NEDD4L	IDA		Human	PMID:21463633
Molecular Function	GO:0019870	potassium channel inhibitor activity	Nedd4l	IMP		Rat	PMID:22879586|RGD:8553349
Molecular Function	GO:0015459	potassium channel regulator activity	NEDD4L	IDA		Human	PMID:17289006
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P37088	Human	PMID:11244092
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P51168	Human	PMID:11244092
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P51170	Human	PMID:11244092
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q9BSA4	Human	PMID:18577513
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P61916	Human	PMID:19664597
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P49281	Human	PMID:19706893
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:O54967	Human	PMID:20086093
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P51787	Human	PMID:22024150
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:P51787	Human	PMID:23529131
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q07912	Human	PMID:23686771
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:O14669	Human	PMID:23873930
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q9BZD6	Human	PMID:23873930
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q86YD5	Human	PMID:26854353
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q9P275	Human	PMID:27445338
Molecular Function	GO:0005515	protein binding	NEDD4L	IPI	UniProtKB:Q9H492	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	UniProtKB:Q99N57|UniProtKB:Q9Z2S7-3	Mouse	MGI:MGI:6092647|PMID:19380724
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	PR:Q99MK8	Mouse	PMID:17544362
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	PR:Q9WU38	Mouse	PMID:17544362
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	PR:Q9JJV9	Mouse	PMID:32175648
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	PR:Q8BGW2	Mouse	PMID:31845480
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	RGD:1310053	Rat	PMID:22417925|RGD:6893327
Molecular Function	GO:0005515	protein binding	Nedd4l	IPI	RGD:620688	Rat	PMID:24451387|RGD:9686374
Molecular Function	GO:0019871	sodium channel inhibitor activity	NEDD4L	IDA		Human	PMID:15217910
Molecular Function	GO:0019871	sodium channel inhibitor activity	Nedd4l	IDA		Mouse	PMID:11149908
Molecular Function	GO:0017080	sodium channel regulator activity	NEDD4L	IDA		Human	PMID:11244092
Molecular Function	GO:0044325	transmembrane transporter binding	NEDD4L	IPI	UniProtKB:Q14524	Human	PMID:15217910
Molecular Function	GO:0044325	transmembrane transporter binding	NEDD4L	IPI	UniProtKB:Q12809	Human	PMID:21463633
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Nedd4l	IDA		Mouse	PMID:32175648
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Nedd4l	IDA		Mouse	PMID:20504882
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Nedd4l	IDA		Rat	PMID:19953087|RGD:6893330
Cellular Component	GO:0070062	extracellular exosome	NEDD4L	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	NEDD4L	IDA		Human	PMID:22879586
Biological Process	GO:0051649	establishment of localization in cell	Nedd4l	IMP	MGI:MGI:4940977	Mouse	PMID:21300902
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	Nedd4l	IMP		Rat	PMID:22879586|RGD:8553349
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	NEDD4L	IDA		Human	PMID:15217910
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	NEDD4L	IDA		Human	PMID:15217910
Biological Process	GO:0010766	negative regulation of sodium ion transport	Nedd4l	IMP	MGI:MGI:3846431	Mouse	PMID:18524855
Biological Process	GO:0010766	negative regulation of sodium ion transport	Nedd4l	IDA		Mouse	PMID:17715136
Biological Process	GO:0010766	negative regulation of sodium ion transport	Nedd4l	IDA		Mouse	PMID:11149908
Biological Process	GO:0010766	negative regulation of sodium ion transport	Nedd4l	IMP	MGI:MGI:4940977	Mouse	PMID:21300902
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Nedd4l	IMP	MGI:MGI:3846431	Mouse	PMID:18524855
Biological Process	GO:2001259	positive regulation of cation channel activity	Nedd4l	IGI	MGI:MGI:1338071	Mouse	PMID:18981174
Biological Process	GO:2001288	positive regulation of caveolin-mediated endocytosis	Nedd4l	IMP		Rat	PMID:22879586|RGD:8553349
Biological Process	GO:1903861	positive regulation of dendrite extension	NEDD4L	IDA		Human	PMID:23999003
Biological Process	GO:0045732	positive regulation of protein catabolic process	Nedd4l	IMP		Rat	PMID:18174164|RGD:6893331
Biological Process	GO:0010765	positive regulation of sodium ion transport	Nedd4l	IGI	MGI:MGI:1338071	Mouse	PMID:18981174
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:0070936	protein K48-linked ubiquitination	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:0006513	protein monoubiquitination	Nedd4l	IMP		Rat	PMID:21332718|RGD:6893329
Biological Process	GO:0016567	protein ubiquitination	NEDD4L	IDA		Human	PMID:15217910
Biological Process	GO:0016567	protein ubiquitination	NEDD4L	IDA		Human	PMID:25631046
Biological Process	GO:0016567	protein ubiquitination	NEDD4L	IMP		Human	PMID:27445338
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	Nedd4l	IDA		Mouse	PMID:20504882
Biological Process	GO:0003254	regulation of membrane depolarization	NEDD4L	IDA		Human	PMID:15217910
Biological Process	GO:0042391	regulation of membrane potential	NEDD4L	IDA		Human	PMID:17289006
Biological Process	GO:0060306	regulation of membrane repolarization	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	NEDD4L	IDA		Human	PMID:17289006
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	NEDD4L	IDA		Human	PMID:17289006
Biological Process	GO:0031647	regulation of protein stability	NEDD4L	IMP		Human	PMID:27445338
Biological Process	GO:1902305	regulation of sodium ion transmembrane transport	NEDD4L	IDA		Human	PMID:11244092
Biological Process	GO:0002028	regulation of sodium ion transport	Nedd4l	IDA		Mouse	PMID:32175648
Biological Process	GO:0009651	response to salt stress	Nedd4l	IMP	MGI:MGI:3846431	Mouse	PMID:18524855
Biological Process	GO:0006814	sodium ion transport	Nedd4l	IMP	MGI:MGI:4940977	Mouse	PMID:21300902
Biological Process	GO:0006814	sodium ion transport	Nedd4l	IMP	MGI:MGI:3846431	Mouse	PMID:18524855
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	NEDD4L	IDA		Human	PMID:21463633
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Nedd4l	IDA		Mouse	PMID:32175648
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	Nedd4l	IMP		Rat	PMID:22879586|RGD:8553349

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern