Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEFH
  • Mouse genes Nefh
  • Rat genes Nefh
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nefh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NEFH	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NEFH	IPI	UniProtKB:P10809	Human	PMID:32814053
Molecular Function	GO:0019901	protein kinase binding	NEFH	IPI	UniProtKB:Q13627-2	Human	PMID:24327345
Molecular Function	GO:0019901	protein kinase binding	NEFH	IPI	UniProtKB:Q03114	Human	PMID:9313898
Molecular Function	GO:0044877	protein-containing complex binding	Nefh	IDA		Rat	PMID:9388258|RGD:9743943
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Nefh	IDA		Rat	PMID:11034913|RGD:8554743
Molecular Function	GO:0005200	structural constituent of cytoskeleton	NEFH	IMP		Human	PMID:7536898
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Nefh	IDA		Rat	PMID:11034913|RGD:8554743
Molecular Function	GO:0099184	structural constituent of postsynaptic intermediate filament cytoskeleton	Nefh	IMP		Mouse	PMID:25869803
Molecular Function	GO:0099184	structural constituent of postsynaptic intermediate filament cytoskeleton	Nefh	IDA		Mouse	PMID:25869803
Molecular Function	GO:0015643	toxic substance binding	Nefh	IDA		Rat	PMID:9221839|RGD:9743940
Cellular Component	GO:0097440	apical dendrite	Nefh	IDA		Rat	PMID:27457532|RGD:27372873
Cellular Component	GO:0030424	axon	Nefh	IDA		Mouse	PMID:8110465
Cellular Component	GO:0030424	axon	Nefh	IDA		Rat	PMID:21119615|RGD:8554416
Cellular Component	GO:0030424	axon	Nefh	IDA		Rat	PMID:7507064|RGD:9693700
Cellular Component	GO:0150017	basal proximal dendrite	Nefh	IDA		Rat	PMID:27457532|RGD:27372873
Cellular Component	GO:0005737	cytoplasm	NEFH	IDA		Human	PMID:27040688
Cellular Component	GO:0005737	cytoplasm	Nefh	IDA		Rat	PMID:11034913|RGD:8554743
Cellular Component	GO:0005737	cytoplasm	Nefh	IDA		Rat	PMID:22315443|RGD:9698432
Cellular Component	GO:0005856	cytoskeleton	NEFH	IDA		Human	PMID:24327345
Cellular Component	GO:0005882	intermediate filament	Nefh	IDA		Rat	PMID:11034913|RGD:8554743
Cellular Component	GO:0005882	intermediate filament	Nefh	IDA		Rat	PMID:2230956|RGD:729261
Cellular Component	GO:0005739	mitochondrion	Nefh	HDA		Mouse	PMID:14651853
Cellular Component	GO:0043209	myelin sheath	Nefh	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0097418	neurofibrillary tangle	NEFH	IDA		Human	PMID:21828286
Cellular Component	GO:0005883	neurofilament	Nefh	IDA		Mouse	PMID:15248193
Cellular Component	GO:0005883	neurofilament	Nefh	IDA		Mouse	PMID:20176735
Cellular Component	GO:0005883	neurofilament	Nefh	IDA		Mouse	PMID:10221457
Cellular Component	GO:0043025	neuronal cell body	Nefh	IDA		Rat	PMID:27457532|RGD:27372873
Cellular Component	GO:0005634	nucleus	Nefh	IDA		Rat	PMID:1898595|RGD:9698427
Cellular Component	GO:0043204	perikaryon	Nefh	IDA		Rat	PMID:8544917|RGD:9693735
Cellular Component	GO:0014069	postsynaptic density	Nefh	IDA		Mouse	PMID:17114649
Cellular Component	GO:0099160	postsynaptic intermediate filament cytoskeleton	Nefh	IDA		Mouse	PMID:25869803
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Nefh	IMP		Mouse	PMID:25869803
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Nefh	IDA		Mouse	PMID:25869803
Biological Process	GO:0061564	axon development	NEFH	IMP		Human	PMID:7536898
Biological Process	GO:0061564	axon development	Nefh	IMP		Mouse	MGI:MGI:2183394|PMID:9763431
Biological Process	GO:0031103	axon regeneration	Nefh	IDA		Rat	PMID:10646539|RGD:9698439
Biological Process	GO:0007420	brain development	Nefh	IDA		Rat	PMID:19530163|RGD:9693727
Biological Process	GO:0071392	cellular response to estradiol stimulus	Nefh	IEP		Rat	PMID:17401155|RGD:9698429
Biological Process	GO:0071447	cellular response to hydroperoxide	Nefh	IEP		Rat	PMID:30041238|RGD:27372875
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Nefh	IEP		Mouse	PMID:20439489
Biological Process	GO:0034599	cellular response to oxidative stress	Nefh	IEP		Rat	PMID:17401155|RGD:9698429
Biological Process	GO:0021987	cerebral cortex development	Nefh	IEP		Rat	PMID:10439464|RGD:9743942
Biological Process	GO:0021766	hippocampus development	Nefh	IEP		Rat	PMID:14620872|RGD:9743946
Biological Process	GO:0045110	intermediate filament bundle assembly	Nefh	IGI	MGI:MGI:97314	Mouse	PMID:10461886
Biological Process	GO:0045110	intermediate filament bundle assembly	Nefh	IGI	MGI:MGI:97313	Mouse	PMID:10461886
Biological Process	GO:0045110	intermediate filament bundle assembly	Nefh	IGI	UniProtKB:P08551	Rat	PMID:11034913|RGD:8554743
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	Nefh	IMP	MGI:MGI:2183246	Mouse	PMID:14561875
Biological Process	GO:0000226	microtubule cytoskeleton organization	Nefh	IGI	MGI:MGI:97314	Mouse	PMID:10461886
Biological Process	GO:0033693	neurofilament bundle assembly	NEFH	IMP		Human	PMID:7536898
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Nefh	IMP	MGI:MGI:2387787	Mouse	PMID:20633607
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Nefh	IGI	MGI:MGI:97314	Mouse	PMID:10461886
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Nefh	IGI	MGI:MGI:97313	Mouse	PMID:10461886
Biological Process	GO:0031175	neuron projection development	Nefh	IEP		Rat	PMID:1898595|RGD:9698427
Biological Process	GO:0001552	ovarian follicle atresia	Nefh	IDA		Rat	PMID:22315443|RGD:9698432
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	Nefh	IMP	MGI:MGI:2387787	Mouse	PMID:20633607
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Nefh	IDA		Mouse	PMID:25869803
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Nefh	IMP		Mouse	PMID:25869803
Biological Process	GO:1902513	regulation of organelle transport along microtubule	NEFH	IMP		Human	PMID:7536898
Biological Process	GO:1903937	response to acrylamide	Nefh	IEP		Rat	PMID:17043767|RGD:2299006
Biological Process	GO:0042220	response to cocaine	Nefh	IEP		Rat	PMID:24507117|RGD:9693734
Biological Process	GO:1903935	response to sodium arsenite	Nefh	IDA		Rat	PMID:18674524|RGD:9693729
Biological Process	GO:0021510	spinal cord development	Nefh	IEP		Rat	PMID:2108255|RGD:9698442

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern