Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEFM
  • Mouse genes Nefm
  • Rat genes Nefm
  • Zfish genes nefma,nefmb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nefm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P05412	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P06400	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:Q15796	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P05412	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P08670	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P07196	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P08670	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P07196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEFM	IPI	UniProtKB:P08670	Human	PMID:32296183
Molecular Function	GO:0044877	protein-containing complex binding	Nefm	IDA		Rat	PMID:9388258|RGD:9743943
Molecular Function	GO:0005102	signaling receptor binding	Nefm	IPI	RGD:2518	Rat	PMID:12122054|RGD:9698445
Molecular Function	GO:0015643	toxic substance binding	Nefm	IDA		Rat	PMID:9221839|RGD:9743940
Cellular Component	GO:0030424	axon	Nefm	IDA		Mouse	PMID:19389377
Cellular Component	GO:0030424	axon	Nefm	IDA		Mouse	PMID:12971893
Cellular Component	GO:0030424	axon	Nefm	IDA		Mouse	PMID:10712642
Cellular Component	GO:0030424	axon	Nefm	IDA		Mouse	PMID:8110465
Cellular Component	GO:0030424	axon	Nefm	IDA		Mouse	PMID:10482234
Cellular Component	GO:0030424	axon	Nefm	IDA		Rat	PMID:19563171|RGD:9743939
Cellular Component	GO:0030424	axon	Nefm	IDA		Rat	PMID:20118926|RGD:8553528
Cellular Component	GO:0005856	cytoskeleton	Nefm	IDA		Rat	PMID:1321159|RGD:727531
Cellular Component	GO:0005882	intermediate filament	Nefm	IDA		Rat	PMID:1321159|RGD:727531
Cellular Component	GO:0045111	intermediate filament cytoskeleton	NEFM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043209	myelin sheath	Nefm	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0097418	neurofibrillary tangle	NEFM	IDA		Human	PMID:21828286
Cellular Component	GO:0005883	neurofilament	Nefm	IDA		Mouse	PMID:10482234
Cellular Component	GO:0005883	neurofilament	Nefm	IDA		Mouse	PMID:10221457
Cellular Component	GO:0005883	neurofilament	Nefm	IDA		Mouse	PMID:15248193
Cellular Component	GO:0005883	neurofilament	Nefm	IDA		Mouse	PMID:12971893
Cellular Component	GO:0005883	neurofilament	Nefm	IDA		Rat	PMID:7721944|RGD:9743935
Cellular Component	GO:0031594	neuromuscular junction	Nefm	IDA		Mouse	PMID:20826656
Cellular Component	GO:0031594	neuromuscular junction	Nefm	IDA		Mouse	PMID:15713258
Cellular Component	GO:0031594	neuromuscular junction	Nefm	IDA		Mouse	PMID:16012337
Cellular Component	GO:0043005	neuron projection	Nefm	IDA		Mouse	PMID:23861879
Cellular Component	GO:0043005	neuron projection	Nefm	IDA		Mouse	PMID:21884692
Cellular Component	GO:0043204	perikaryon	Nefm	IDA		Rat	PMID:8544917|RGD:9693735
Cellular Component	GO:0014069	postsynaptic density	Nefm	IDA		Mouse	PMID:17114649
Cellular Component	GO:0099160	postsynaptic intermediate filament cytoskeleton	Nefm	IDA		Mouse	PMID:25869803
Cellular Component	GO:0099182	presynaptic intermediate filament cytoskeleton	Nefm	IDA		Mouse	PMID:25869803
Biological Process	GO:0008088	axo-dendritic transport	Nefm	IMP	MGI:MGI:2180106	Mouse	PMID:10461886
Biological Process	GO:0031103	axon regeneration	Nefm	IEP		Rat	PMID:15206821|RGD:9698447
Biological Process	GO:0071392	cellular response to estradiol stimulus	Nefm	IEP		Rat	PMID:17401155|RGD:9698429
Biological Process	GO:0034599	cellular response to oxidative stress	Nefm	IEP		Rat	PMID:17401155|RGD:9698429
Biological Process	GO:0021987	cerebral cortex development	Nefm	IEP		Rat	PMID:10439464|RGD:9743942
Biological Process	GO:0021766	hippocampus development	Nefm	IEP		Rat	PMID:14620872|RGD:9743946
Biological Process	GO:0045110	intermediate filament bundle assembly	Nefm	IGI	MGI:MGI:97313	Mouse	PMID:10461886
Biological Process	GO:0045110	intermediate filament bundle assembly	Nefm	IGI	MGI:MGI:97309	Mouse	PMID:10461886
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	Nefm	IMP	MGI:MGI:2180135	Mouse	PMID:14561875
Biological Process	GO:0045105	intermediate filament polymerization or depolymerization	Nefm	IDA		Rat	PMID:10362553|RGD:9698446
Biological Process	GO:0000226	microtubule cytoskeleton organization	Nefm	IGI	MGI:MGI:97309	Mouse	PMID:10461886
Biological Process	GO:0033693	neurofilament bundle assembly	Nefm	IDA		Rat	PMID:7721944|RGD:9743935
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Nefm	IMP	MGI:MGI:2180135	Mouse	PMID:9566972
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Nefm	IGI	MGI:MGI:97309	Mouse	PMID:10461886
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Nefm	IGI	MGI:MGI:97313	Mouse	PMID:10461886
Biological Process	GO:0031133	regulation of axon diameter	Nefm	IMP	MGI:MGI:2180135	Mouse	PMID:9566972
Biological Process	GO:0031133	regulation of axon diameter	Nefm	IMP	MGI:MGI:2180106	Mouse	PMID:10461886
Biological Process	GO:1903937	response to acrylamide	Nefm	IEP		Rat	PMID:17043767|RGD:2299006
Biological Process	GO:0021510	spinal cord development	Nefm	IEP		Rat	PMID:2108255|RGD:9698442

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern