Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEK1
  • Mouse genes Nek1
  • Rat genes Nek1
  • Zfish genes nek1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nek1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Nek1	IDA		Mouse	MGI:MGI:5902880|PMID:28235073
Molecular Function	GO:0016301	kinase activity	NEK1	IMP		Human	PMID:19158487
Molecular Function	GO:0005515	protein binding	NEK1	IPI	UniProtKB:Q99689	Human	PMID:14690447
Molecular Function	GO:0005515	protein binding	NEK1	IPI	UniProtKB:Q9UHY8	Human	PMID:14690447
Molecular Function	GO:0005515	protein binding	NEK1	IPI	UniProtKB:Q5S007	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	NEK1	IPI	UniProtKB:Q5S007	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	NEK1	IPI	UniProtKB:O43822	Human	PMID:26167768
Molecular Function	GO:0005515	protein binding	NEK1	IPI	UniProtKB:O43822	Human	PMID:26290490
Molecular Function	GO:0004672	protein kinase activity	NEK1	IDA		Human	PMID:15604234
Cellular Component	GO:0034451	centriolar satellite	NEK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	NEK1	IDA		Human	PMID:21399614
Cellular Component	GO:0005813	centrosome	Nek1	IDA		Mouse	MGI:MGI:5285178|PMID:16267153
Cellular Component	GO:0005737	cytoplasm	NEK1	IDA		Human	PMID:15604234
Cellular Component	GO:0005829	cytosol	NEK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NEK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NEK1	IDA		Human	PMID:15604234
Cellular Component	GO:0005634	nucleus	Nek1	IDA		Mouse	PMID:19699716
Cellular Component	GO:0000242	pericentriolar material	NEK1	IDA		Human	PMID:21211617
Biological Process	GO:0060271	cilium assembly	NEK1	IMP		Human	PMID:21211617
Biological Process	GO:0060271	cilium assembly	nek1	IMP	ZFIN:ZDB-MRPHLNO-170403-2	Zfish	PMID:26167768
Biological Process	GO:0060271	cilium assembly	nek1	IMP	ZFIN:ZDB-MRPHLNO-170403-3	Zfish	PMID:26167768
Biological Process	GO:1904888	cranial skeletal system development	nek1	IMP	ZFIN:ZDB-MRPHLNO-170403-2	Zfish	PMID:26167768
Biological Process	GO:0006974	DNA damage response	Nek1	IMP	MGI:MGI:1858122	Mouse	PMID:15604234
Biological Process	GO:0001822	kidney development	Nek1	IMP	MGI:MGI:1858030	Mouse	PMID:10618398
Biological Process	GO:0001822	kidney development	Nek1	IMP	MGI:MGI:1858122	Mouse	PMID:10618398
Biological Process	GO:0035264	multicellular organism growth	Nek1	IMP	MGI:MGI:1858030	Mouse	PMID:10618398
Biological Process	GO:0035264	multicellular organism growth	Nek1	IMP	MGI:MGI:1858122	Mouse	PMID:10618398
Biological Process	GO:0006468	protein phosphorylation	NEK1	IDA		Human	PMID:19158487
Biological Process	GO:2000001	regulation of DNA damage checkpoint	Nek1	IMP		Mouse	MGI:MGI:5619475|PMID:18843199
Biological Process	GO:0010212	response to ionizing radiation	Nek1	IMP	MGI:MGI:1858122	Mouse	PMID:15604234
Biological Process	GO:0007283	spermatogenesis	Nek1	IMP	MGI:MGI:1858122	Mouse	PMID:10618398
Biological Process	GO:0007283	spermatogenesis	Nek1	IMP	MGI:MGI:1858030	Mouse	PMID:10618398

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern