Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEK6
  • Mouse genes Nek6
  • Rat genes Nek6
  • Zfish genes nek6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nek6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	NEK6	IDA		Human	PMID:14563848
Molecular Function	GO:0140297	DNA-binding transcription factor binding	NEK6	IPI	UniProtKB:P18848	Human	PMID:20873783
Molecular Function	GO:0019894	kinesin binding	NEK6	IPI	UniProtKB:P52732	Human	PMID:19001501
Molecular Function	GO:0000287	magnesium ion binding	NEK6	IDA		Human	PMID:14563848
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q13526	Human	PMID:16476580
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:O14559	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P21246	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P30048	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P60953	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P62081	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q01201	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q15650	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q5T890	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q96QH2	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q9H9E1	Human	PMID:20873783
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P98170	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q07912	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q0VD86	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q13422	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q5VWN6-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q7Z6G3-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q8IYA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q8TBB1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q9BPX1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q9BRK4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q9UKT9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P15884	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P36406	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q0VD86	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q9UKT9	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:P98170	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NEK6	IPI	UniProtKB:Q9UKT9	Human	PMID:31515488
Molecular Function	GO:0019901	protein kinase binding	NEK6	IPI	UniProtKB:Q8TD19	Human	PMID:19001501
Molecular Function	GO:0004674	protein serine/threonine kinase activity	NEK6	IDA		Human	PMID:14563848
Molecular Function	GO:0004674	protein serine/threonine kinase activity	NEK6	IDA		Human	PMID:19001501
Molecular Function	GO:0004674	protein serine/threonine kinase activity	NEK6	IDA		Human	PMID:20873783
Molecular Function	GO:0001222	transcription corepressor binding	NEK6	IPI	UniProtKB:Q86X95	Human	PMID:20873783
Molecular Function	GO:0031625	ubiquitin protein ligase binding	NEK6	IPI	UniProtKB:Q7Z6E9	Human	PMID:20873783
Cellular Component	GO:0034451	centriolar satellite	NEK6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	NEK6	IDA		Human	PMID:20873783
Cellular Component	GO:0005737	cytoplasm	NEK6	IDA		Human	PMID:12054534
Cellular Component	GO:0005737	cytoplasm	Nek6	IDA		Mouse	MGI:MGI:1350562|PMID:10964517
Cellular Component	GO:0005829	cytosol	NEK6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NEK6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NEK6	IDA		Human	PMID:12054534
Cellular Component	GO:0032991	protein-containing complex	NEK6	IDA		Human	PMID:20873783
Biological Process	GO:0007059	chromosome segregation	NEK6	IDA		Human	PMID:14563848
Biological Process	GO:0018105	peptidyl-serine phosphorylation	NEK6	IDA		Human	PMID:19001501
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	NEK6	HMP		Human	PMID:12761501
Biological Process	GO:0046777	protein autophosphorylation	NEK6	IDA		Human	PMID:14563848
Biological Process	GO:0046777	protein autophosphorylation	NEK6	IDA		Human	PMID:20873783
Biological Process	GO:0006468	protein phosphorylation	NEK6	IDA		Human	PMID:12840024
Biological Process	GO:0006468	protein phosphorylation	NEK6	IDA		Human	PMID:31409757
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition	NEK6	IDA		Human	PMID:14563848

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern