Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEK8
  • Mouse genes Nek8
  • Rat genes Nek8
  • Zfish genes nek8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nek8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q7Z494	Human	PMID:23418306
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q8WVJ2	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q86WT6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q9CZK6	Human	PMID:26188091
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q8WVJ2	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:O76081-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q52LG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q6UY14-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q86WT6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q8IWZ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q8TDS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:Q8WVJ2	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NEK8	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nek8	IPI	UniProtKB:O35245	Mouse	MGI:MGI:3849381|PMID:18235101
Molecular Function	GO:0005515	protein binding	Nek8	IPI	UniProtKB:O89019	Mouse	MGI:MGI:5013991|PMID:21565611
Molecular Function	GO:0005515	protein binding	Nek8	IPI	UniProtKB:O89019	Mouse	MGI:MGI:5512938|PMID:22687244
Molecular Function	GO:0005515	protein binding	Nek8	IPI	UniProtKB:Q9CZK6	Mouse	MGI:MGI:5621197|PMID:25671767
Molecular Function	GO:0005515	protein binding	Nek8	IPI	PR:Q7TNH6	Mouse	PMID:29395339
Molecular Function	GO:0005515	protein binding	Nek8	IPI	PR:Q6GQX6	Mouse	PMID:29395339
Cellular Component	GO:0097546	ciliary base	Nek8	IDA		Mouse	PMID:20169535
Cellular Component	GO:0097543	ciliary inversin compartment	Nek8	IDA		Mouse	PMID:29395339
Cellular Component	GO:0097543	ciliary inversin compartment	Nek8	IDA		Mouse	PMID:20169535
Cellular Component	GO:0005929	cilium	NEK8	IMP		Human	PMID:18199800
Cellular Component	GO:0005929	cilium	Nek8	IDA		Mouse	MGI:MGI:5285178|PMID:16267153
Cellular Component	GO:0005929	cilium	nek8	IDA		Zfish	PMID:22687244
Biological Process	GO:0009887	animal organ morphogenesis	NEK8	IMP		Human	PMID:23418306
Biological Process	GO:0061371	determination of heart left/right asymmetry	nek8	IMP	ZFIN:ZDB-MRPHLNO-120521-1	Zfish	PMID:23274954
Biological Process	GO:0007368	determination of left/right symmetry	Nek8	IMP		Mouse	PMID:25807483
Biological Process	GO:0007507	heart development	Nek8	IMP		Mouse	PMID:25807483
Biological Process	GO:0001947	heart looping	nek8	IGI	ZFIN:ZDB-MRPHLNO-080929-3,ZFIN:ZDB-MRPHLNO-120809-2	Zfish	PMID:22687244
Biological Process	GO:0001947	heart looping	nek8	IMP	ZFIN:ZDB-MRPHLNO-120521-1	Zfish	PMID:23274954
Biological Process	GO:0048793	pronephros development	nek8	IGI	ZFIN:ZDB-MRPHLNO-120521-1,ZFIN:ZDB-MRPHLNO-130910-9	Zfish	PMID:23793029
Biological Process	GO:0072116	pronephros formation	nek8	IGI	ZFIN:ZDB-MRPHLNO-080929-3,ZFIN:ZDB-MRPHLNO-120809-2	Zfish	PMID:22687244
Biological Process	GO:0035330	regulation of hippo signaling	NEK8	IDA		Human	PMID:23418306
Biological Process	GO:0061326	renal tubule development	nek8	IMP	ZFIN:ZDB-MRPHLNO-120521-1	Zfish	PMID:12421721
Biological Process	GO:0061326	renal tubule development	nek8	IMP	ZFIN:ZDB-MRPHLNO-120521-2	Zfish	PMID:12421721

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern