Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NF1
  • Mouse genes Nf1
  • Rat genes Nf1
  • Zfish genes nf1a,nf1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	NF1	IDA		Human	PMID:1568247
Molecular Function	GO:0005096	GTPase activator activity	NF1	IDA		Human	PMID:1570015
Molecular Function	GO:0005096	GTPase activator activity	NF1	IDA		Human	PMID:2121371
Molecular Function	GO:0005096	GTPase activator activity	Nf1	IMP		Mouse	PMID:17053831
Molecular Function	GO:0005096	GTPase activator activity	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Molecular Function	GO:0005096	GTPase activator activity	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:8563750
Molecular Function	GO:0005096	GTPase activator activity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16271875
Molecular Function	GO:0005096	GTPase activator activity	Nf1	IGI	MGI:MGI:96159	Mouse	PMID:16271875
Molecular Function	GO:0005096	GTPase activator activity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:11435472
Molecular Function	GO:0008017	microtubule binding	Nf1	IDA		Rat	PMID:7568895|RGD:8553797
Molecular Function	GO:0031210	phosphatidylcholine binding	NF1	IDA		Human	PMID:17187824
Molecular Function	GO:0008429	phosphatidylethanolamine binding	NF1	IDA		Human	PMID:17187824
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:P34741	Human	PMID:11356864
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:P05067	Human	PMID:16374483
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:P50406	Human	PMID:23027611
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:P01112	Human	PMID:26635368
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:Q7Z699	Human	PMID:26635368
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:P01112	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	NF1	IPI	UniProtKB:Q7Z698	Human	PMID:34626534
Molecular Function	GO:0005515	protein binding	Nf1	IPI	PR:P49817	Mouse	PMID:16405917
Molecular Function	GO:0005515	protein binding	Nf1	IPI	RGD:62004	Rat	PMID:11356864|RGD:1599282
Molecular Function	GO:0005515	protein binding	Nf1	IPI	RGD:2517	Rat	PMID:18313395|RGD:2316244
Molecular Function	GO:0045545	syndecan binding	Nf1	IPI	RGD:3649	Rat	PMID:11356864|RGD:1599282
Molecular Function	GO:0045545	syndecan binding	Nf1	IPI	RGD:621486	Rat	PMID:11356864|RGD:1599282
Cellular Component	GO:0030424	axon	NF1	IDA		Human	PMID:1550670
Cellular Component	GO:0030424	axon	Nf1	IDA		Rat	PMID:11356864|RGD:1599282
Cellular Component	GO:0030424	axon	Nf1	IDA		Rat	PMID:1550670|RGD:8554751
Cellular Component	GO:0005737	cytoplasm	Nf1	IDA		Mouse	PMID:15133494
Cellular Component	GO:0005737	cytoplasm	Nf1	IDA		Rat	PMID:1550670|RGD:8554751
Cellular Component	GO:0005737	cytoplasm	Nf1	IDA		Rat	PMID:19919880|RGD:2325195
Cellular Component	GO:0030425	dendrite	NF1	IDA		Human	PMID:1550670
Cellular Component	GO:0030425	dendrite	Nf1	IDA		Rat	PMID:1550670|RGD:8554751
Cellular Component	GO:0098978	glutamatergic synapse	Nf1	IDA		Mouse	PMID:22105171
Cellular Component	GO:0098978	glutamatergic synapse	Nf1	IMP		Mouse	PMID:22105171
Cellular Component	GO:0098978	glutamatergic synapse	Nf1	EXP		Rat	PMID:24431436|RGD:155230796
Cellular Component	GO:0098978	glutamatergic synapse	Nf1	IDA		Rat	PMID:24431436|RGD:155230796
Cellular Component	GO:0098978	glutamatergic synapse	Nf1	IMP		Rat	PMID:24431436|RGD:155230796
Cellular Component	GO:0016020	membrane	NF1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Nf1	IDA		Rat	PMID:11356864|RGD:1599282
Cellular Component	GO:0043005	neuron projection	Nf1	IDA		Rat	PMID:11356864|RGD:1599282
Cellular Component	GO:0005634	nucleus	Nf1	IDA		Rat	PMID:1550670|RGD:8554751
Cellular Component	GO:0014069	postsynaptic density	Nf1	IDA		Rat	PMID:11356864|RGD:1599282
Cellular Component	GO:0032991	protein-containing complex	Nf1	IDA		Rat	PMID:11356864|RGD:1599282
Biological Process	GO:0030036	actin cytoskeleton organization	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0030036	actin cytoskeleton organization	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16405917
Biological Process	GO:0030325	adrenal gland development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16906226
Biological Process	GO:0021764	amygdala development	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0001525	angiogenesis	Nf1	IGI	MGI:MGI:95516	Mouse	PMID:16648142
Biological Process	GO:0006915	apoptotic process	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0048844	artery morphogenesis	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0048708	astrocyte differentiation	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0048708	astrocyte differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10442636
Biological Process	GO:0048708	astrocyte differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9878702
Biological Process	GO:0001568	blood vessel development	nf1a	IGI	ZFIN:ZDB-GENE-030131-4907,ZFIN:ZDB-GENE-091111-4	Zfish	PMID:19966217
Biological Process	GO:0001568	blood vessel development	nf1a	IMP	ZFIN:ZDB-MRPHLNO-100323-1	Zfish	PMID:19966217
Biological Process	GO:0001568	blood vessel development	nf1b	IMP	ZFIN:ZDB-MRPHLNO-100323-2	Zfish	PMID:19966217
Biological Process	GO:0001568	blood vessel development	nf1b	IGI	ZFIN:ZDB-GENE-030131-4907,ZFIN:ZDB-GENE-091111-4	Zfish	PMID:19966217
Biological Process	GO:0007420	brain development	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10419687
Biological Process	GO:0048593	camera-type eye morphogenesis	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0007154	cell communication	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10442636
Biological Process	GO:0016477	cell migration	Nf1	IGI	MGI:MGI:1914172	Mouse	PMID:14724565
Biological Process	GO:0016477	cell migration	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:0016477	cell migration	Nf1	IGI	MGI:MGI:98179	Mouse	PMID:14724565
Biological Process	GO:0016477	cell migration	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:14724565
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10383727
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:97846	Mouse	PMID:11435472
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10442636
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:8563750
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:11401406
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:11435472
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:2176057,MGI:MGI:2176073	Mouse	PMID:14982883
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:10620616
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10498620
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9001241
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0008283	cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11401406
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:10973261
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	UniProtKB:Q02297	Mouse	PMID:9001241
Biological Process	GO:0008283	cell population proliferation	Nf1	IGI	MGI:MGI:96677	Mouse	PMID:10620616
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Nf1	IEP		Rat	PMID:8892969|RGD:12789704
Biological Process	GO:0034605	cellular response to heat	Nf1	IDA		Mouse	PMID:20661302
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Nf1	IEP		Rat	PMID:8892969|RGD:12789704
Biological Process	GO:0021987	cerebral cortex development	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0050890	cognition	NF1	IMP		Human	PMID:17299016
Biological Process	GO:0030199	collagen fibril organization	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10383727
Biological Process	GO:0001935	endothelial cell proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16288202
Biological Process	GO:0001935	endothelial cell proliferation	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:0030198	extracellular matrix organization	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16835260
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:15039234
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:15039234
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:15039234
Biological Process	GO:0048144	fibroblast proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10383727
Biological Process	GO:0021897	forebrain astrocyte development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0048853	forebrain morphogenesis	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0061534	gamma-aminobutyric acid secretion, neurotransmission	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0014009	glial cell proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:11246230
Biological Process	GO:0014009	glial cell proliferation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10442636
Biological Process	GO:0014009	glial cell proliferation	Nf1	IGI	MGI:MGI:97874	Mouse	PMID:11246230
Biological Process	GO:0014009	glial cell proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11246230
Biological Process	GO:0014009	glial cell proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:10973261
Biological Process	GO:0014009	glial cell proliferation	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0061535	glutamate secretion, neurotransmission	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0046959	habituation	nf1a	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:25176649
Biological Process	GO:0046959	habituation	nf1a	IGI	ZFIN:ZDB-GENE-091111-4	Zfish	PMID:25176649
Biological Process	GO:0046959	habituation	nf1b	IGI	ZFIN:ZDB-GENE-030131-4907	Zfish	PMID:25176649
Biological Process	GO:0046959	habituation	nf1b	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:25176649
Biological Process	GO:0048820	hair follicle maturation	Nf1	IMP	MGI:MGI:4364806	Mouse	PMID:25340873
Biological Process	GO:0007507	heart development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0007507	heart development	Nf1	IMP	MGI:MGI:2176057,MGI:MGI:2450311	Mouse	PMID:12469121
Biological Process	GO:0007507	heart development	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:7920653
Biological Process	GO:0007507	heart development	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10419687
Biological Process	GO:0007507	heart development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16906226
Biological Process	GO:0007507	heart development	nf1a	IMP	ZFIN:ZDB-MRPHLNO-100323-1	Zfish	PMID:19966217
Biological Process	GO:0007507	heart development	nf1b	IMP	ZFIN:ZDB-MRPHLNO-100323-2	Zfish	PMID:19966217
Biological Process	GO:0071887	leukocyte apoptotic process	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:17053831
Biological Process	GO:0001889	liver development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0060291	long-term synaptic potentiation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16271875
Biological Process	GO:0060291	long-term synaptic potentiation	Nf1	IGI	MGI:MGI:96159	Mouse	PMID:16271875
Biological Process	GO:0000165	MAPK cascade	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:14724565
Biological Process	GO:0000165	MAPK cascade	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16644864
Biological Process	GO:0033024	mast cell apoptotic process	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:15039234
Biological Process	GO:0033024	mast cell apoptotic process	Nf1	IGI	MGI:MGI:99255	Mouse	PMID:15039234
Biological Process	GO:0033024	mast cell apoptotic process	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:15039234
Biological Process	GO:0070662	mast cell proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:10620616
Biological Process	GO:0070662	mast cell proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:11435472
Biological Process	GO:0070662	mast cell proliferation	Nf1	IGI	MGI:MGI:96677	Mouse	PMID:10620616
Biological Process	GO:0070662	mast cell proliferation	Nf1	IGI	MGI:MGI:97846	Mouse	PMID:11435472
Biological Process	GO:0007613	memory	nf1a	IMP	ZFIN:ZDB-GENO-141222-6	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1a	IMP	ZFIN:ZDB-GENO-130530-7	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1a	IGI	ZFIN:ZDB-GENE-091111-4	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1a	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1b	IGI	ZFIN:ZDB-GENE-030131-4907	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1b	IMP	ZFIN:ZDB-GENO-141222-7	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1b	IMP	ZFIN:ZDB-GENO-130530-8	Zfish	PMID:25176649
Biological Process	GO:0007613	memory	nf1b	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:25176649
Biological Process	GO:0001656	metanephros development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0022011	myelination in peripheral nervous system	Nf1	IMP		Mouse	PMID:10586246
Biological Process	GO:0033028	myeloid cell apoptotic process	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:17053831
Biological Process	GO:0097529	myeloid leukocyte migration	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:17053831
Biological Process	GO:0097529	myeloid leukocyte migration	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0016525	negative regulation of angiogenesis	Nf1	IGI	MGI:MGI:95516	Mouse	PMID:16648142
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10442636
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9878702
Biological Process	GO:0030336	negative regulation of cell migration	NF1	IMP		Human	PMID:16648142
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:8563750
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:11401406
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:10591652
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10498620
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11401406
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf1	IMP	MGI:MGI:2176057,MGI:MGI:2176073	Mouse	PMID:14982883
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:17053831
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	NF1	IMP		Human	PMID:16648142
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	NF1	IMP		Human	PMID:17404841
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16288202
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	nf1a	IMP	ZFIN:ZDB-GENO-110614-2,ZFIN:ZDB-MRPHLNO-100323-4,ZFIN:ZDB-MRPHLNO-110614-3	Zfish	PMID:20858602
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	nf1b	IMP	ZFIN:ZDB-GENO-110614-2,ZFIN:ZDB-MRPHLNO-100323-4,ZFIN:ZDB-MRPHLNO-110614-3	Zfish	PMID:20858602
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Nf1	IMP		Mouse	MGI:MGI:4887526|PMID:20154697
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10383727
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11246230
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10442636
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Nf1	IGI	MGI:MGI:97874	Mouse	PMID:11246230
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:11246230
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:10973261
Biological Process	GO:0002686	negative regulation of leukocyte migration	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:17053831
Biological Process	GO:0002686	negative regulation of leukocyte migration	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IGI	MGI:MGI:96677	Mouse	PMID:10620616
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IGI	MGI:MGI:96159	Mouse	PMID:16271875
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IGI	MGI:MGI:96159	Mouse	PMID:12409258
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:12409258
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16271875
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:10620616
Biological Process	GO:0043409	negative regulation of MAPK cascade	NF1	IMP		Human	PMID:16648142
Biological Process	GO:0043409	negative regulation of MAPK cascade	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16644864
Biological Process	GO:0070667	negative regulation of mast cell proliferation	Nf1	IGI	MGI:MGI:96677	Mouse	PMID:10620616
Biological Process	GO:0070667	negative regulation of mast cell proliferation	Nf1	IGI	MGI:MGI:97846	Mouse	PMID:11435472
Biological Process	GO:0070667	negative regulation of mast cell proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:11435472
Biological Process	GO:0070667	negative regulation of mast cell proliferation	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:10620616
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0046929	negative regulation of neurotransmitter secretion	Nf1	IGI	MGI:MGI:97321	Mouse	PMID:16298082
Biological Process	GO:0046929	negative regulation of neurotransmitter secretion	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16298082
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Nf1	IGI	MGI:MGI:1100089	Mouse	PMID:17053831
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:17053831
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0042308	negative regulation of protein import into nucleus	Nf1	IMP	MGI:MGI:2176057,MGI:MGI:2450311	Mouse	PMID:12469121
Biological Process	GO:0006469	negative regulation of protein kinase activity	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0006469	negative regulation of protein kinase activity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16835260
Biological Process	GO:0035021	negative regulation of Rac protein signal transduction	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IMP	MGI:MGI:2176057	Mouse	PMID:15665300
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16835260
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16893911
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11246230
Biological Process	GO:1900148	negative regulation of Schwann cell migration	Nf1	IGI	MGI:MGI:98179	Mouse	PMID:14724565
Biological Process	GO:1900148	negative regulation of Schwann cell migration	Nf1	IGI	MGI:MGI:1914172	Mouse	PMID:14724565
Biological Process	GO:1900148	negative regulation of Schwann cell migration	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:14724565
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9001241
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	Nf1	IGI	UniProtKB:Q02297	Mouse	PMID:9001241
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:10591653
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:0021915	neural tube development	Nf1	IGI	MGI:MGI:97487	Mouse	PMID:10419687
Biological Process	GO:0007405	neuroblast proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0007405	neuroblast proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0051402	neuron apoptotic process	Nf1	IGI	MGI:MGI:96224	Mouse	PMID:10845775
Biological Process	GO:0051402	neuron apoptotic process	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7671302
Biological Process	GO:0051402	neuron apoptotic process	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0051402	neuron apoptotic process	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:10845775
Biological Process	GO:0007269	neurotransmitter secretion	Nf1	IGI	MGI:MGI:97321	Mouse	PMID:16298082
Biological Process	GO:0007269	neurotransmitter secretion	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16298082
Biological Process	GO:0098597	observational learning	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0048709	oligodendrocyte differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0070444	oligodendrocyte progenitor proliferation	nf1a	IMP	ZFIN:ZDB-GENO-110614-2,ZFIN:ZDB-MRPHLNO-100323-4,ZFIN:ZDB-MRPHLNO-110614-3	Zfish	PMID:20858602
Biological Process	GO:0070444	oligodendrocyte progenitor proliferation	nf1b	IMP	ZFIN:ZDB-GENO-110614-2,ZFIN:ZDB-MRPHLNO-100323-4,ZFIN:ZDB-MRPHLNO-110614-3	Zfish	PMID:20858602
Biological Process	GO:0001649	osteoblast differentiation	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16893911
Biological Process	GO:0030316	osteoclast differentiation	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0030316	osteoclast differentiation	Nf1	IGI	MGI:MGI:1100089	Mouse	PMID:17053831
Biological Process	GO:0030316	osteoclast differentiation	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:17053831
Biological Process	GO:0007422	peripheral nervous system development	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10419687
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:14724565
Biological Process	GO:0043473	pigmentation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10594763
Biological Process	GO:0043473	pigmentation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10844550
Biological Process	GO:0043473	pigmentation	Nf1	IGI	MGI:MGI:96677	Mouse	PMID:10620616
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11788835
Biological Process	GO:0043065	positive regulation of apoptotic process	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:15039234
Biological Process	GO:0043547	positive regulation of GTPase activity	NF1	IMP		Human	PMID:16648142
Biological Process	GO:0043547	positive regulation of GTPase activity	NF1	IDA		Human	PMID:2121371
Biological Process	GO:0043547	positive regulation of GTPase activity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:11435472
Biological Process	GO:0043547	positive regulation of GTPase activity	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:8563750
Biological Process	GO:2000108	positive regulation of leukocyte apoptotic process	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:17053831
Biological Process	GO:0033027	positive regulation of mast cell apoptotic process	Nf1	IGI	MGI:MGI:97583	Mouse	PMID:15039234
Biological Process	GO:0033027	positive regulation of mast cell apoptotic process	Nf1	IGI	MGI:MGI:99255	Mouse	PMID:15039234
Biological Process	GO:0033027	positive regulation of mast cell apoptotic process	Nf1	IGI	MGI:MGI:96974	Mouse	PMID:15039234
Biological Process	GO:0033034	positive regulation of myeloid cell apoptotic process	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:17053831
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7671302
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:10845775
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Nf1	IGI	MGI:MGI:96224	Mouse	PMID:10845775
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Nf1	IMP	MGI:MGI:2176055,MGI:MGI:2176057	Mouse	PMID:11297510
Biological Process	GO:0010976	positive regulation of neuron projection development	Nf1	IMP		Rat	PMID:23358504|RGD:12789705
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:0098926	postsynaptic signal transduction	Nf1	EXP		Rat	PMID:24431436|RGD:155230796
Biological Process	GO:0098926	postsynaptic signal transduction	Nf1	IDA		Rat	PMID:24431436|RGD:155230796
Biological Process	GO:0098926	postsynaptic signal transduction	Nf1	IMP		Rat	PMID:24431436|RGD:155230796
Biological Process	GO:0006606	protein import into nucleus	Nf1	IMP	MGI:MGI:2176057,MGI:MGI:2450311	Mouse	PMID:12469121
Biological Process	GO:0016601	Rac protein signal transduction	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:10498620
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:15665300
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16835260
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16893911
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:10845775
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:15944386
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:8563750
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:2176057	Mouse	PMID:15665300
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:2176057,MGI:MGI:2450311	Mouse	PMID:12469121
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IGI	MGI:MGI:96224	Mouse	PMID:10845775
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:11246230
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9001241
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16906226
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IGI	MGI:MGI:1339753	Mouse	PMID:17053831
Biological Process	GO:0007265	Ras protein signal transduction	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:11435472
Biological Process	GO:0045765	regulation of angiogenesis	NF1	IMP		Human	PMID:17404841
Biological Process	GO:0045765	regulation of angiogenesis	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16288202
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	NF1	IMP		Human	PMID:17404841
Biological Process	GO:0045124	regulation of bone resorption	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:17053831
Biological Process	GO:0051726	regulation of cell cycle	nf1a	IMP	ZFIN:ZDB-GENO-170315-9	Zfish	PMID:27130733
Biological Process	GO:0042127	regulation of cell population proliferation	Nf1	IGI	MGI:MGI:1339752	Mouse	PMID:10678181
Biological Process	GO:0001952	regulation of cell-matrix adhesion	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16405917
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:16271875
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Nf1	IGI	MGI:MGI:96159	Mouse	PMID:16271875
Biological Process	GO:0010468	regulation of gene expression	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0045685	regulation of glial cell differentiation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:12904481
Biological Process	GO:0045685	regulation of glial cell differentiation	nf1a	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:22773753
Biological Process	GO:0045685	regulation of glial cell differentiation	nf1b	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:22773753
Biological Process	GO:0060251	regulation of glial cell proliferation	nf1a	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:22773753
Biological Process	GO:0060251	regulation of glial cell proliferation	nf1b	IGI	ZFIN:ZDB-GENO-130528-1	Zfish	PMID:22773753
Biological Process	GO:0043087	regulation of GTPase activity	NF1	IMP		Human	PMID:1570015
Biological Process	GO:0043087	regulation of GTPase activity	Nf1	IMP		Rat	PMID:1570015|RGD:1358398
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:11793011
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:11793011
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0043408	regulation of MAPK cascade	Nf1	IGI	MGI:MGI:1339975	Mouse	PMID:25242307
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	Nf1	EXP		Rat	PMID:24431436|RGD:155230796
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	Nf1	IDA		Rat	PMID:24431436|RGD:155230796
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	Nf1	IMP		Rat	PMID:24431436|RGD:155230796
Biological Process	GO:0045664	regulation of neuron differentiation	Nf1	IMP		Rat	PMID:18218617|RGD:2316246
Biological Process	GO:0099175	regulation of postsynapse organization	Nf1	IDA		Mouse	PMID:22105171
Biological Process	GO:0099175	regulation of postsynapse organization	Nf1	IMP		Mouse	PMID:22105171
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:11793011
Biological Process	GO:0001666	response to hypoxia	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16288202
Biological Process	GO:0014044	Schwann cell development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9001241
Biological Process	GO:0014037	Schwann cell differentiation	Nf1	IEP		Rat	PMID:7505343|RGD:12789707
Biological Process	GO:0036135	Schwann cell migration	Nf1	IGI	MGI:MGI:1914172	Mouse	PMID:14724565
Biological Process	GO:0036135	Schwann cell migration	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:14724565
Biological Process	GO:0036135	Schwann cell migration	Nf1	IGI	MGI:MGI:98179	Mouse	PMID:14724565
Biological Process	GO:0014010	Schwann cell proliferation	Nf1	IGI	UniProtKB:Q02297	Mouse	PMID:9001241
Biological Process	GO:0014010	Schwann cell proliferation	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:9001241
Biological Process	GO:0007519	skeletal muscle tissue development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0048745	smooth muscle tissue development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0021510	spinal cord development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16906226
Biological Process	GO:0072089	stem cell proliferation	Nf1	IGI	MGI:MGI:98834	Mouse	PMID:10591653
Biological Process	GO:0048485	sympathetic nervous system development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:7926784
Biological Process	GO:0048485	sympathetic nervous system development	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:16906226
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	Nf1	IGI	MGI:MGI:97528	Mouse	PMID:16644864
Biological Process	GO:0008542	visual learning	Nf1	IGI	MGI:MGI:96159	Mouse	PMID:16271875
Biological Process	GO:0008542	visual learning	Nf1	IGI	MGI:MGI:96680	Mouse	PMID:11793011
Biological Process	GO:0008542	visual learning	Nf1	IMP	MGI:MGI:1857478	Mouse	PMID:11793011
Biological Process	GO:0008542	visual learning	Nf1	IGI	MGI:MGI:95819	Mouse	PMID:9054942
Biological Process	GO:0042060	wound healing	Nf1	IMP	MGI:MGI:1857444	Mouse	PMID:10383727

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern