Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NF2
  • Mouse genes Nf2
  • Rat genes Nf2
  • Zfish genes nf2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Nf2	IPI	RGD:70487	Rat	PMID:15659388|RGD:1599271
Molecular Function	GO:0005178	integrin binding	Nf2	IPI	RGD:2927	Rat	PMID:9858254|RGD:1599274
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:P0DPB4	Human	PMID:10669747
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O14964	Human	PMID:10861283
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9H204	Human	PMID:15467741
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q10728	Human	PMID:16885985
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9BZE4	Human	PMID:17210637
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O14745	Human	PMID:17242191
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q96HU1	Human	PMID:17509819
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q00013	Human	PMID:19144871
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9Y4B6	Human	PMID:20178741
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q16584	Human	PMID:20890305
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9NZM5	Human	PMID:21167305
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5	Human	PMID:21481793
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5-1	Human	PMID:21481793
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5-2	Human	PMID:21481793
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q8NI35	Human	PMID:21481793
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O60341	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O95835	Human	PMID:24012335
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q4VCS5	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O60341	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O75530-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:O76041	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:P17024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:P54274-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q13573	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q14525	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q15776	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q5TAQ9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q5VYS8-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q6H8Q1-8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q6X4W1-6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q6ZNE9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q6ZNH5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q6ZR37	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q7Z3I7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q86WT6-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q8IZU1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q8NEZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q8TBB1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q8WWB5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q8WXF7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q96KP6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q99598	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9BY12-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9C0F3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9UNE7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q9UNS2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NF2	IPI	UniProtKB:Q01082	Human	PMID:9537418
Molecular Function	GO:0005515	protein binding	Nf2	IPI	UniProtKB:Q4VCS5	Mouse	MGI:MGI:5586945|PMID:25026211
Molecular Function	GO:0005515	protein binding	Nf2	IPI	UniProtKB:O95835	Mouse	MGI:MGI:5586945|PMID:25026211
Molecular Function	GO:0005515	protein binding	Nf2	IPI	PR:Q02248	Mouse	PMID:12695331
Molecular Function	GO:0005515	protein binding	Nf2	IPI	PR:O88643	Mouse	PMID:14580336
Molecular Function	GO:0005515	protein binding	Nf2	IPI	PR:Q60631	Mouse	PMID:16405865
Molecular Function	GO:0005515	protein binding	Nf2	IPI	RGD:2307	Rat	PMID:15659388|RGD:1599271
Molecular Function	GO:0005515	protein binding	Nf2	IPI	UniProtKB:A0A0G2JX94	Rat	PMID:21481793|RGD:8554001
Molecular Function	GO:0019904	protein domain specific binding	Nf2	IPI	RGD:2307	Rat	PMID:11316791|RGD:1599273
Cellular Component	GO:0005912	adherens junction	Nf2	IMP	MGI:MGI:1857941	Mouse	PMID:12695331
Cellular Component	GO:0045177	apical part of cell	Nf2	IDA		Mouse	PMID:23863479
Cellular Component	GO:0044297	cell body	Nf2	IDA		Mouse	PMID:25433207
Cellular Component	GO:0032154	cleavage furrow	Nf2	IDA		Mouse	PMID:9631655
Cellular Component	GO:0030864	cortical actin cytoskeleton	Nf2	IDA		Mouse	PMID:15467741
Cellular Component	GO:0005737	cytoplasm	NF2	IDA		Human	PMID:9537418
Cellular Component	GO:0005737	cytoplasm	Nf2	IDA		Mouse	PMID:8547603
Cellular Component	GO:0005737	cytoplasm	Nf2	IDA		Mouse	PMID:15133494
Cellular Component	GO:0005737	cytoplasm	Nf2	IDA		Rat	PMID:15659388|RGD:1599271
Cellular Component	GO:0005856	cytoskeleton	Nf2	IDA		Mouse	PMID:15467741
Cellular Component	GO:0005829	cytosol	NF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005769	early endosome	NF2	IDA		Human	PMID:10861283
Cellular Component	GO:0030175	filopodium	Nf2	IDA		Mouse	PMID:9563848
Cellular Component	GO:0030027	lamellipodium	Nf2	IDA		Mouse	PMID:9563848
Cellular Component	GO:0016020	membrane	NF2	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	Nf2	IDA		Rat	PMID:18199961|RGD:2289939
Cellular Component	GO:0043005	neuron projection	Nf2	IDA		Mouse	PMID:25433207
Cellular Component	GO:0005730	nucleolus	NF2	IDA		Human	PMID:9537418
Cellular Component	GO:0005634	nucleus	NF2	IDA		Human	PMID:10401006
Cellular Component	GO:0005634	nucleus	NF2	IDA		Human	PMID:20178741
Cellular Component	GO:0005634	nucleus	Nf2	IDA		Mouse	PMID:15133494
Cellular Component	GO:0048471	perinuclear region of cytoplasm	NF2	IDA		Human	PMID:17210637
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nf2	IDA		Rat	PMID:9858254|RGD:1599274
Cellular Component	GO:0005886	plasma membrane	NF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	NF2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005886	plasma membrane	NF2	IDA		Human	PMID:10401006
Cellular Component	GO:0005886	plasma membrane	Nf2	IDA		Rat	PMID:9858254|RGD:1599274
Cellular Component	GO:0032991	protein-containing complex	Nf2	IDA		Rat	PMID:11316791|RGD:1599273
Cellular Component	GO:0001726	ruffle	Nf2	IDA		Mouse	PMID:9563848
Cellular Component	GO:0045202	synapse	Nf2	IDA		Rat	PMID:15797715|RGD:2315003
Biological Process	GO:0030036	actin cytoskeleton organization	NF2	IMP		Human	PMID:9537418
Biological Process	GO:0048513	animal organ development	Nf2	IEP		Rat	PMID:7795605|RGD:633510
Biological Process	GO:0007420	brain development	Nf2	IMP		Mouse	PMID:23863479
Biological Process	GO:0045216	cell-cell junction organization	Nf2	IMP	MGI:MGI:1857941	Mouse	PMID:12695331
Biological Process	GO:0007398	ectoderm development	Nf2	IMP	MGI:MGI:1857941	Mouse	PMID:9171370
Biological Process	GO:0021766	hippocampus development	Nf2	IMP		Mouse	PMID:23863479
Biological Process	GO:0070306	lens fiber cell differentiation	Nf2	IMP		Mouse	MGI:MGI:4457460|PMID:20181838
Biological Process	GO:0000165	MAPK cascade	Nf2	IMP		Mouse	PMID:16405865
Biological Process	GO:0001707	mesoderm formation	Nf2	IMP	MGI:MGI:1857941	Mouse	PMID:9171370
Biological Process	GO:0030308	negative regulation of cell growth	Nf2	IDA		Rat	PMID:11316791|RGD:1599273
Biological Process	GO:0008285	negative regulation of cell population proliferation	NF2	IDA		Human	PMID:12444102
Biological Process	GO:0008285	negative regulation of cell population proliferation	NF2	IMP		Human	PMID:17210637
Biological Process	GO:0008285	negative regulation of cell population proliferation	NF2	IDA		Human	PMID:20178741
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nf2	IMP	MGI:MGI:1857941	Mouse	PMID:9553042
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	NF2	IDA		Human	PMID:17210637
Biological Process	GO:0043409	negative regulation of MAPK cascade	Nf2	IMP		Mouse	PMID:16405865
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	Nf2	IMP	MGI:MGI:1926957	Mouse	PMID:10887156
Biological Process	GO:0006469	negative regulation of protein kinase activity	Nf2	IDA		Mouse	PMID:14580336
Biological Process	GO:0006469	negative regulation of protein kinase activity	Nf2	IMP		Mouse	PMID:16405865
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	NF2	IDA		Human	PMID:12444102
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	Nf2	IMP	MGI:MGI:1926957	Mouse	PMID:10887156
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	NF2	IDA		Human	PMID:12444102
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Nf2	IMP	MGI:MGI:1926957	Mouse	PMID:10887156
Biological Process	GO:0033687	osteoblast proliferation	Nf2	IMP	MGI:MGI:1926957	Mouse	PMID:10887156
Biological Process	GO:0045597	positive regulation of cell differentiation	Nf2	IMP		Mouse	PMID:23863479
Biological Process	GO:0051496	positive regulation of stress fiber assembly	NF2	IMP		Human	PMID:9537418
Biological Process	GO:0042981	regulation of apoptotic process	NF2	IMP		Human	PMID:21167305
Biological Process	GO:0051726	regulation of cell cycle	NF2	IMP		Human	PMID:21167305
Biological Process	GO:0042127	regulation of cell population proliferation	Nf2	IMP	MGI:MGI:1857941	Mouse	PMID:12695331
Biological Process	GO:0014013	regulation of gliogenesis	Nf2	IMP	MGI:MGI:1926955	Mouse	PMID:25433207
Biological Process	GO:0035330	regulation of hippo signaling	NF2	IMP		Human	PMID:20159598
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	Nf2	IMP		Mouse	PMID:23863479
Biological Process	GO:0050767	regulation of neurogenesis	Nf2	IMP	MGI:MGI:1926955	Mouse	PMID:25433207
Biological Process	GO:1900180	regulation of protein localization to nucleus	Nf2	IMP		Mouse	PMID:23863479
Biological Process	GO:0031647	regulation of protein stability	Nf2	IMP		Mouse	PMID:23863479
Biological Process	GO:0072091	regulation of stem cell proliferation	Nf2	IGI	MGI:MGI:103262	Mouse	PMID:25433207
Biological Process	GO:0072091	regulation of stem cell proliferation	Nf2	IMP	MGI:MGI:1926955	Mouse	PMID:25433207
Biological Process	GO:0014010	Schwann cell proliferation	NF2	IMP		Human	PMID:17353411
Biological Process	GO:0014010	Schwann cell proliferation	Nf2	IMP	MGI:MGI:1926957	Mouse	PMID:10887156

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern