Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFASC
  • Mouse genes Nfasc
  • Rat genes Nfasc
  • Zfish genes nfasca,nfascb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfasc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NFASC	IPI	UniProtKB:Q99972	Human	PMID:23897819
Molecular Function	GO:0005515	protein binding	Nfasc	IPI	UniProtKB:O70624	Mouse	MGI:MGI:5527213|PMID:23897819
Molecular Function	GO:0005515	protein binding	Nfasc	IPI	UniProtKB:Q00954	Rat	PMID:11470829|RGD:13825432
Molecular Function	GO:0086080	protein binding involved in heterotypic cell-cell adhesion	Nfasc	IGI	MGI:MGI:2388361	Mouse	PMID:20188654
Molecular Function	GO:0019904	protein domain specific binding	Nfasc	IPI	RGD:621161	Rat	PMID:17045809|RGD:7207801
Cellular Component	GO:0030424	axon	Nfasc	IDA		Mouse	PMID:16701205
Cellular Component	GO:0030424	axon	Nfasc	IDA		Mouse	PMID:15479642
Cellular Component	GO:0030424	axon	Nfasc	IDA		Rat	PMID:22649224|RGD:12904752
Cellular Component	GO:0043194	axon initial segment	Nfasc	IDA		Mouse	PMID:26671463
Cellular Component	GO:0043194	axon initial segment	Nfasc	IDA		Rat	PMID:11724816|RGD:8553674
Cellular Component	GO:0043194	axon initial segment	Nfasc	IDA		Rat	PMID:22649224|RGD:12904752
Cellular Component	GO:0043194	axon initial segment	Nfasc	IDA		Rat	PMID:27356871|RGD:12793037
Cellular Component	GO:0043194	axon initial segment	Nfasc	IDA		Rat	PMID:28426968|RGD:13514087
Cellular Component	GO:0030425	dendrite	Nfasc	IDA		Rat	PMID:22649224|RGD:12904752
Cellular Component	GO:0005925	focal adhesion	NFASC	HDA		Human	PMID:21423176
Cellular Component	GO:0043209	myelin sheath	Nfasc	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0033268	node of Ranvier	Nfasc	IDA		Mouse	MGI:MGI:3836161|PMID:19185024
Cellular Component	GO:0033268	node of Ranvier	Nfasc	IDA		Mouse	MGI:MGI:5629915|PMID:25653379
Cellular Component	GO:0033268	node of Ranvier	Nfasc	IDA		Rat	PMID:11470829|RGD:13825432
Cellular Component	GO:0033268	node of Ranvier	Nfasc	IDA		Rat	PMID:16652168|RGD:8553545
Cellular Component	GO:0033268	node of Ranvier	Nfasc	IDA		Rat	PMID:17709431|RGD:14392774
Cellular Component	GO:0033010	paranodal junction	Nfasc	IDA		Mouse	MGI:MGI:3836161|PMID:19185024
Cellular Component	GO:0033010	paranodal junction	Nfasc	IDA		Mouse	PMID:18048693
Cellular Component	GO:0033270	paranode region of axon	Nfasc	IDA		Mouse	MGI:MGI:2675529|PMID:12975355
Cellular Component	GO:0033270	paranode region of axon	Nfasc	IDA		Mouse	PMID:16723544
Cellular Component	GO:0005886	plasma membrane	NFASC	IDA		Human	PMID:30850329
Cellular Component	GO:0005886	plasma membrane	Nfasc	IDA		Mouse	PMID:15479642
Cellular Component	GO:0005886	plasma membrane	Nfasc	IDA		Rat	PMID:11470829|RGD:13825432
Cellular Component	GO:0097454	Schwann cell microvillus	Nfasc	IDA		Rat	PMID:17045809|RGD:7207801
Cellular Component	GO:0005918	septate junction	Nfasc	IDA		Mouse	PMID:27583434
Biological Process	GO:0007411	axon guidance	Nfasc	IDA		Mouse	PMID:15479642
Biological Process	GO:0032289	central nervous system myelin formation	nfascb	IMP	ZFIN:ZDB-GENO-200716-6	Zfish	PMID:31761670
Biological Process	GO:0045162	clustering of voltage-gated sodium channels	Nfasc	IMP	MGI:MGI:3808598	Mouse	PMID:20188654
Biological Process	GO:0042552	myelination	Nfasc	IEP		Rat	PMID:16652168|RGD:8553545
Biological Process	GO:0030913	paranodal junction assembly	Nfasc	IMP		Mouse	MGI:MGI:3836161|PMID:19185024
Biological Process	GO:0030913	paranodal junction assembly	Nfasc	IMP	MGI:MGI:3808598	Mouse	PMID:16337912
Biological Process	GO:0030913	paranodal junction assembly	Nfasc	IMP	MGI:MGI:4837620	Mouse	PMID:20371806
Biological Process	GO:0007422	peripheral nervous system development	Nfasc	IEP		Rat	PMID:16652168|RGD:8553545
Biological Process	GO:0071205	protein localization to juxtaparanode region of axon	Nfasc	IMP	MGI:MGI:4837620	Mouse	PMID:20371806
Biological Process	GO:0002175	protein localization to paranode region of axon	Nfasc	IMP	MGI:MGI:4837620	Mouse	PMID:20371806
Biological Process	GO:0072659	protein localization to plasma membrane	Nfasc	IDA		Rat	PMID:16525039|RGD:8554229
Biological Process	GO:0050808	synapse organization	Nfasc	IMP		Mouse	PMID:15479642
Biological Process	GO:0019226	transmission of nerve impulse	Nfasc	IMP	MGI:MGI:3808598	Mouse	PMID:16337912

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern