Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFAT5
  • Mouse genes Nfat5
  • Rat genes Nfat5
  • Zfish genes nfat5a,nfat5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfat5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	NFAT5	IDA		Human	PMID:34049076
Molecular Function	GO:0003677	DNA binding	Nfat5	IDA		Mouse	PMID:15790681
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NFAT5	IDA		Human	PMID:11485737
Molecular Function	GO:0005515	protein binding	NFAT5	IPI	UniProtKB:P17844	Human	PMID:22266867
Molecular Function	GO:0005515	protein binding	NFAT5	IPI	UniProtKB:Q92841	Human	PMID:22266867
Molecular Function	GO:0005515	protein binding	NFAT5	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFAT5	IDA		Human	PMID:11485737
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFAT5	IDA		Human	PMID:11780147
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFAT5	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Nfat5	IDA		Mouse	PMID:11934689
Cellular Component	GO:0005737	cytoplasm	Nfat5	IDA		Rat	PMID:20585028|RGD:8693586
Cellular Component	GO:0005829	cytosol	NFAT5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NFAT5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NFAT5	IDA		Human	PMID:12370307
Cellular Component	GO:0005634	nucleus	Nfat5	IDA		Mouse	PMID:11934689
Cellular Component	GO:0005634	nucleus	Nfat5	IDA		Mouse	PMID:10860829
Cellular Component	GO:0005634	nucleus	Nfat5	IDA		Rat	PMID:20585028|RGD:8693586
Biological Process	GO:0071345	cellular response to cytokine stimulus	NFAT5	IMP		Human	PMID:25515214
Biological Process	GO:0001816	cytokine production	Nfat5	IDA		Mouse	PMID:15790681
Biological Process	GO:0006974	DNA damage response	NFAT5	IDA		Human	PMID:34049076
Biological Process	GO:0021782	glial cell development	nfat5b	IMP	ZFIN:ZDB-CRISPR-191008-24,ZFIN:ZDB-CRISPR-191008-25	Zfish	PMID:30924555
Biological Process	GO:0007507	heart development	nfat5a	IMP	ZFIN:ZDB-MRPHLNO-160930-1	Zfish	PMID:27368804
Biological Process	GO:0010628	positive regulation of gene expression	Nfat5	IDA		Mouse	PMID:21357543
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	NFAT5	IMP		Human	PMID:25515214
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NFAT5	IMP		Human	PMID:25515214
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFAT5	IDA		Human	PMID:11485737
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfat5	IDA		Mouse	PMID:11934689
Biological Process	GO:0062176	R-loop processing	NFAT5	IDA		Human	PMID:34049076
Biological Process	GO:0070884	regulation of calcineurin-NFAT signaling cascade	Nfat5	IDA		Mouse	PMID:19188439
Biological Process	GO:0006970	response to osmotic stress	Nfat5	IEP		Rat	PMID:20585028|RGD:8693586
Biological Process	GO:0060041	retina development in camera-type eye	nfat5b	IMP	ZFIN:ZDB-CRISPR-191008-24,ZFIN:ZDB-CRISPR-191008-25	Zfish	PMID:30924555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern