Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nfatc1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NFATC1
- Mouse genes Nfatc1
- Rat genes Nfatc1
- Zfish genes nfatc1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfatc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nfatc1	IDA		Mouse	PMID:24301466
Molecular Function	GO:0003677	DNA binding	Nfatc1	IDA		Mouse	PMID:23980096
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfatc1	IDA		Mouse	MGI:MGI:5306313\|PMID:15304486
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Nfatc1	IDA		Mouse	MGI:MGI:5306313\|PMID:15304486
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Nfatc1	IPI	UniProtKB:Q92908	Mouse	MGI:MGI:4887344\|PMID:11889139
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nfatc1	IDA		Mouse	PMID:18408153
Molecular Function	GO:0048273	mitogen-activated protein kinase p38 binding	Nfatc1	IPI	UniProtKB:P47811	Mouse	MGI:MGI:5306313\|PMID:15304486
Molecular Function	GO:0003676	nucleic acid binding	NFATC1	EXP		Human	PMID:8990122
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:O15294	Human	PMID:17882263
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:Q9NSB8	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:Q9NSC5	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P51141	Human	PMID:21880741
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:Q08209-1	Human	PMID:23468591
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:Q08209-1	Human	PMID:24954618
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P05412	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P15336	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P16220	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P18846	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P18847	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	NFATC1	IPI	UniProtKB:P31276	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	Nfatc1	IPI	UniProtKB:P51141	Mouse	MGI:MGI:5295911\|PMID:21880741
Molecular Function	GO:0005515	protein binding	Nfatc1	IPI	UniProtKB:Q913V3:PRO_0000278754	Mouse	MGI:MGI:5616323\|PMID:15380363
Molecular Function	GO:0005515	protein binding	Nfatc1	IPI	UniProtKB:Q9WVB3	Mouse	MGI:MGI:6478056\|PMID:23990468
Molecular Function	GO:0005515	protein binding	Nfatc1	IPI	PR:O88895	Mouse	PMID:19463978
Molecular Function	GO:0005515	protein binding	Nfatc1	IPI	RGD:2664	Rat	PMID:12557015\|RGD:9587809
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc1	IDA		Mouse	MGI:MGI:5306313\|PMID:15304486
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc1	IDA		Mouse	PMID:18625840
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nfatc1	IMP		Rat	PMID:14979875\|RGD:10047233
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Nfatc1	IPI	UniProtKB:P17433	Mouse	MGI:MGI:5306313\|PMID:15304486
Molecular Function	GO:0043565	sequence-specific DNA binding	Nfatc1	IDA		Mouse	PMID:15058383
Molecular Function	GO:0043565	sequence-specific DNA binding	Nfatc1	IDA		Mouse	PMID:7650004
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFATC1	IDA		Human	PMID:28473536
Molecular Function	GO:0001223	transcription coactivator binding	Nfatc1	IPI	RGD:620036	Rat	PMID:22566696\|RGD:7327214
Cellular Component	GO:0000785	chromatin	NFATC1	IDA		Human	PMID:15304486
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	MGI:MGI:5306313\|PMID:15304486
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	MGI:MGI:4443285\|PMID:19626032
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	PMID:12469121
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	PMID:12091710
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	PMID:21982707
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	PMID:10903175
Cellular Component	GO:0005737	cytoplasm	Nfatc1	IDA		Mouse	PMID:19463978
Cellular Component	GO:0016604	nuclear body	NFATC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NFATC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NFATC1	IDA		Human	PMID:12370307
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	MGI:MGI:4443285\|PMID:19626032
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	MGI:MGI:5795811\|PMID:24039232
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	MGI:MGI:5706679\|PMID:26644563
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	MGI:MGI:6478056\|PMID:23990468
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	MGI:MGI:5306313\|PMID:15304486
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:9515964
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:12970181
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:18978355
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:19233265
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:11782539
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:15850572
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:9515963
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:18243104
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:21982707
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:10903175
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:19463978
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Mouse	PMID:21464233
Cellular Component	GO:0005634	nucleus	Nfatc1	IDA		Rat	PMID:14979875\|RGD:10047233
Cellular Component	GO:0005667	transcription regulator complex	Nfatc1	IPI	PR:Q60591	Mouse	PMID:19561615
Cellular Component	GO:0005667	transcription regulator complex	Nfatc1	IPI	UniProtKB:Q8CD15	Mouse	PMID:19561615
Biological Process	GO:0003176	aortic valve development	Nfatc1	IMP		Mouse	MGI:MGI:5319103\|PMID:22300732
Biological Process	GO:0003180	aortic valve morphogenesis	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:9515964
Biological Process	GO:0003181	atrioventricular valve morphogenesis	nfatc1	IGI	ZFIN:ZDB-GENO-210512-2	Zfish	PMID:32070236
Biological Process	GO:0003181	atrioventricular valve morphogenesis	nfatc1	IMP	ZFIN:ZDB-GENO-210511-19	Zfish	PMID:32070236
Biological Process	GO:0002337	B-1a B cell differentiation	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:14595020
Biological Process	GO:0060854	branching involved in lymph vessel morphogenesis	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:19233265
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	NFATC1	IDA		Human	PMID:14979875
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Nfatc1	IMP		Mouse	PMID:19233265
Biological Process	GO:0006816	calcium ion transport	Nfatc1	IMP		Mouse	PMID:12660151
Biological Process	GO:0044838	cell quiescence	Nfatc1	IMP	MGI:MGI:2181726	Mouse	PMID:18243104
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Nfatc1	IEP		Rat	PMID:23110133\|RGD:151665477
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Nfatc1	IEP		Rat	PMID:23110133\|RGD:151665477
Biological Process	GO:0003197	endocardial cushion development	Nfatc1	IGI	UniProtKB:P61022	Mouse	MGI:MGI:5319103\|PMID:22300732
Biological Process	GO:0001837	epithelial to mesenchymal transition	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:15339668
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	Nfatc1	IMP		Mouse	PMID:12660151
Biological Process	GO:0007507	heart development	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:15339668
Biological Process	GO:0061384	heart trabecula morphogenesis	Nfatc1	IMP	MGI:MGI:2181766	Mouse	PMID:9515963
Biological Process	GO:0003170	heart valve development	Nfatc1	IMP		Mouse	MGI:MGI:5319103\|PMID:22300732
Biological Process	GO:0003179	heart valve morphogenesis	Nfatc1	IMP	MGI:MGI:2181766	Mouse	PMID:9515963
Biological Process	GO:0035556	intracellular signal transduction	NFATC1	IDA		Human	PMID:14749367
Biological Process	GO:0043616	keratinocyte proliferation	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:0001946	lymphangiogenesis	Nfatc1	IGI	MGI:MGI:107163	Mouse	PMID:19233265
Biological Process	GO:0001946	lymphangiogenesis	Nfatc1	IGI	MGI:MGI:103178	Mouse	PMID:19233265
Biological Process	GO:0001946	lymphangiogenesis	nfatc1	IMP	ZFIN:ZDB-MRPHLNO-200422-3	Zfish	PMID:31478836
Biological Process	GO:0001946	lymphangiogenesis	nfatc1	IMP	ZFIN:ZDB-GENO-201014-11	Zfish	PMID:31478836
Biological Process	GO:1903131	mononuclear cell differentiation	Nfatc1	IEP		Rat	PMID:23110133\|RGD:151665477
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Nfatc1	IDA		Mouse	PMID:19463978
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:19463978
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfatc1	IGI	MGI:MGI:1343091	Mouse	PMID:19463978
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:1905064	negative regulation of vascular associated smooth muscle cell differentiation	NFATC1	IDA		Human	PMID:23853098
Biological Process	GO:0030316	osteoclast differentiation	Nfatc1	IGI	MGI:MGI:2158925	Mouse	PMID:21982707
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NFATC1	IDA		Human	PMID:14749367
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NFATC1	IDA		Human	PMID:14979875
Biological Process	GO:0010628	positive regulation of gene expression	Nfatc1	IDA		Mouse	PMID:22451653
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFATC1	IDA		Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFATC1	IGI	UniProtKB:P08047	Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFATC1	IGI	UniProtKB:P18146	Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc1	IDA		Mouse	MGI:MGI:5306313\|PMID:15304486
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:17430895
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:19233265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:12808150
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:17442941
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc1	IMP		Rat	PMID:14979875\|RGD:10047233
Biological Process	GO:0003177	pulmonary valve development	Nfatc1	IMP		Mouse	MGI:MGI:5319103\|PMID:22300732
Biological Process	GO:0003184	pulmonary valve morphogenesis	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:9515964
Biological Process	GO:0042634	regulation of hair cycle	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfatc1	IMP		Mouse	MGI:MGI:5297297\|PMID:22019888
Biological Process	GO:0009612	response to mechanical stimulus	nfatc1	IDA		Zfish	PMID:23632157
Biological Process	GO:1905314	semi-lunar valve development	Nfatc1	IMP		Mouse	MGI:MGI:5319103\|PMID:22300732
Biological Process	GO:0072089	stem cell proliferation	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:18243104
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc1	IGI	MGI:MGI:1343091	Mouse	PMID:19463978
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:19233265
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc1	IDA		Mouse	PMID:19463978
Biological Process	GO:0014883	transition between fast and slow fiber	Nfatc1	IMP		Mouse	PMID:18408153
Biological Process	GO:0060412	ventricular septum morphogenesis	Nfatc1	IMP	MGI:MGI:2181762	Mouse	PMID:9515964

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.