Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFATC2
  • Mouse genes Nfatc2
  • Rat genes Nfatc2
  • Zfish genes nfatc2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfatc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	NFATC2	EXP		Human	PMID:29432148
Molecular Function	GO:0003682	chromatin binding	Nfatc2	IDA		Mouse	PMID:24301466
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfatc2	IDA		Mouse	PMID:8235597
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nfatc2	IDA		Mouse	PMID:15319455
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Nfatc2	IDA		Mouse	MGI:MGI:5562625|PMID:24161931
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nfatc2	IDA		Mouse	MGI:MGI:2446371|PMID:12453415
Molecular Function	GO:0060090	molecular adaptor activity	NFATC2	EXP		Human	PMID:29432148
Molecular Function	GO:0019902	phosphatase binding	NFATC2	IPI	UniProtKB:Q08209	Human	PMID:26248042
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q9BZS1	Human	PMID:16873067
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q99JB6	Human	PMID:17377532
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q08209|UniProtKB:Q9NSC5	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q9NSB8	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q9NSC5	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q01664	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q9BZS1	Human	PMID:21458306
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q5S007	Human	PMID:21983832
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q86Y07-1	Human	PMID:23105117
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q86Y07-2	Human	PMID:23105117
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q9UPT9	Human	PMID:24561192
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:Q08209-1	Human	PMID:24954618
Molecular Function	GO:0005515	protein binding	NFATC2	IPI	UniProtKB:P16220	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	Nfatc2	IPI	UniProtKB:Q86Y07-1	Mouse	MGI:MGI:5449457|PMID:23105117
Molecular Function	GO:0005515	protein binding	Nfatc2	IPI	UniProtKB:Q9JHD2	Mouse	MGI:MGI:5926326|PMID:28424240
Molecular Function	GO:0005515	protein binding	Nfatc2	IPI	UniProtKB:P11416	Mouse	MGI:MGI:4411947|PMID:19752193
Molecular Function	GO:0005515	protein binding	Nfatc2	IPI	UniProtKB:Q9JKD8	Mouse	MGI:MGI:5543347|PMID:23616576
Molecular Function	GO:0005515	protein binding	Nfatc2	IPI	UniProtKB:Q99JP6	Mouse	MGI:MGI:5086111|PMID:18218901
Molecular Function	GO:0005515	protein binding	Nfatc2	IPI	PR:O09130	Mouse	PMID:8943202
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc2	IDA		Mouse	MGI:MGI:2446371|PMID:12453415
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc2	IDA		Mouse	PMID:15319455
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc2	IDA		Mouse	PMID:8235597
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc2	IDA		Mouse	PMID:10755616
Molecular Function	GO:0043565	sequence-specific DNA binding	Nfatc2	IDA		Mouse	PMID:8940147
Molecular Function	GO:0043565	sequence-specific DNA binding	Nfatc2	IDA		Mouse	PMID:7650004
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFATC2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Nfatc2	IDA		Mouse	MGI:MGI:4411947|PMID:19752193
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Nfatc2	IDA		Mouse	MGI:MGI:5562625|PMID:24161931
Molecular Function	GO:0008134	transcription factor binding	Nfatc2	IPI	PR:P10085	Mouse	PMID:24301466
Cellular Component	GO:0000785	chromatin	Nfatc2	IDA		Mouse	MGI:MGI:5562625|PMID:24161931
Cellular Component	GO:0005737	cytoplasm	NFATC2	IDA		Human	PMID:12656674
Cellular Component	GO:0005737	cytoplasm	Nfatc2	IDA		Mouse	PMID:15319455
Cellular Component	GO:0005737	cytoplasm	Nfatc2	IDA		Mouse	PMID:23219532
Cellular Component	GO:0005737	cytoplasm	Nfatc2	IDA		Mouse	PMID:21709260
Cellular Component	GO:0005737	cytoplasm	Nfatc2	IDA		Mouse	PMID:8668213
Cellular Component	GO:0005737	cytoplasm	Nfatc2	IDA		Mouse	PMID:12091710
Cellular Component	GO:0005829	cytosol	NFATC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Nfatc2	IDA		Mouse	PMID:31787876
Cellular Component	GO:0005829	cytosol	Nfatc2	IDA		Mouse	PMID:8235597
Cellular Component	GO:0005829	cytosol	Nfatc2	IDA		Mouse	PMID:8973343
Cellular Component	GO:0005829	cytosol	Nfatc2	IDA		Rat	PMID:7961754|RGD:2302391
Cellular Component	GO:0005654	nucleoplasm	NFATC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NFATC2	IDA		Human	PMID:12370307
Cellular Component	GO:0005634	nucleus	NFATC2	IDA		Human	PMID:12656674
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	MGI:MGI:4411947|PMID:19752193
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:23123061
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:15319455
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:8668213
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:31787876
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:8235597
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:23219532
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:25318679
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Mouse	PMID:21295565
Cellular Component	GO:0005634	nucleus	Nfatc2	IDA		Rat	PMID:17596340|RGD:1627651
Cellular Component	GO:1990904	ribonucleoprotein complex	Nfatc2	IDA		Mouse	PMID:21709260
Cellular Component	GO:0035976	transcription factor AP-1 complex	NFATC2	IPI		Human	PMID:9510247
Cellular Component	GO:0005667	transcription regulator complex	Nfatc2	IPI	UniProtKB:B5B2N2	Mouse	PMID:19561615
Cellular Component	GO:0005667	transcription regulator complex	Nfatc2	IDA		Mouse	PMID:8235597
Cellular Component	GO:0005667	transcription regulator complex	Nfatc2	IPI	UniProtKB:Q8CD15	Mouse	PMID:19561615
Biological Process	GO:0050853	B cell receptor signaling pathway	NFATC2	IMP		Human	PMID:17875758
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Nfatc2	IGI	MGI:MGI:107164	Mouse	PMID:18676376
Biological Process	GO:0016477	cell migration	NFATC2	IDA		Human	PMID:21871017
Biological Process	GO:0001816	cytokine production	Nfatc2	IDA		Mouse	PMID:15790681
Biological Process	GO:0006974	DNA damage response	NFATC2	IMP		Human	PMID:17875758
Biological Process	GO:0014904	myotube cell development	Nfatc2	IMP		Mouse	PMID:18676376
Biological Process	GO:0098781	ncRNA transcription	Nfatc2	IMP		Mouse	PMID:29475982
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfatc2	IDA		Mouse	MGI:MGI:2446371|PMID:12453415
Biological Process	GO:1905064	negative regulation of vascular associated smooth muscle cell differentiation	NFATC2	IDA		Human	PMID:23853098
Biological Process	GO:0030890	positive regulation of B cell proliferation	NFATC2	IMP		Human	PMID:17875758
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NFATC2	IDA		Human	PMID:15790681
Biological Process	GO:0010628	positive regulation of gene expression	Nfatc2	IMP		Mouse	MGI:MGI:4411947|PMID:19752193
Biological Process	GO:1901741	positive regulation of myoblast fusion	Nfatc2	IMP	MGI:MGI:2182740	Mouse	PMID:12757709
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc2	IGI	UniProtKB:P63328	Mouse	MGI:MGI:5562625|PMID:24161931
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc2	IDA		Mouse	PMID:15319455
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc2	IDA		Mouse	PMID:10755616
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc2	IGI	MGI:MGI:97275	Mouse	PMID:24301466
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc2	IDA		Mouse	PMID:8235597
Biological Process	GO:0009410	response to xenobiotic stimulus	NFATC2	IMP		Human	PMID:17875758
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc2	IGI	MGI:MGI:97275	Mouse	PMID:24301466

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern