Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFATC3
  • Mouse genes Nfatc3
  • Rat genes Nfatc3
  • Zfish genes nfatc3a,nfatc3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfatc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nfatc3	IDA		Mouse	PMID:16998587
Molecular Function	GO:0003682	chromatin binding	Nfatc3	IDA		Mouse	PMID:24301466
Molecular Function	GO:0003682	chromatin binding	Nfatc3	IDA		Mouse	PMID:21514407
Molecular Function	GO:0003682	chromatin binding	Nfatc3	IDA		Mouse	PMID:18676376
Molecular Function	GO:0003677	DNA binding	Nfatc3	IDA		Mouse	PMID:16260608
Molecular Function	GO:0003677	DNA binding	Nfatc3	IDA		Mouse	PMID:18676376
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NFATC3	IDA		Human	PMID:15173172
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NFATC3	IMP		Human	PMID:15173172
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfatc3	IDA		Mouse	PMID:21514407
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nfatc3	IDA		Mouse	PMID:16260608
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nfatc3	IDA		Mouse	PMID:16998587
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	NFATC3	IGI	UniProtKB:Q14934	Human	PMID:23543060
Molecular Function	GO:0005515	protein binding	NFATC3	IPI	UniProtKB:P04049	Human	PMID:24330068
Molecular Function	GO:0005515	protein binding	Nfatc3	IPI	PR:O54946	Mouse	PMID:16260608
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFATC3	IDA		Human	PMID:15173172
Molecular Function	GO:0043565	sequence-specific DNA binding	Nfatc3	IDA		Mouse	PMID:7650004
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFATC3	IDA		Human	PMID:28473536
Molecular Function	GO:0008134	transcription factor binding	Nfatc3	IDA		Mouse	PMID:18676376
Cellular Component	GO:0005737	cytoplasm	NFATC3	IDA		Human	PMID:18815128
Cellular Component	GO:0005737	cytoplasm	Nfatc3	IDA		Mouse	PMID:12091710
Cellular Component	GO:0005737	cytoplasm	Nfatc3	IDA		Mouse	PMID:16260608
Cellular Component	GO:0005737	cytoplasm	Nfatc3	IDA		Mouse	PMID:23219532
Cellular Component	GO:0005737	cytoplasm	Nfatc3	IDA		Mouse	PMID:9017603
Cellular Component	GO:0005737	cytoplasm	Nfatc3	IDA		Mouse	PMID:14517551
Cellular Component	GO:0005829	cytosol	NFATC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Nfatc3	IDA		Mouse	PMID:20530871
Cellular Component	GO:0005829	cytosol	Nfatc3	IDA		Rat	PMID:15644446|RGD:1358616
Cellular Component	GO:0005654	nucleoplasm	NFATC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NFATC3	IDA		Human	PMID:12370307
Cellular Component	GO:0005634	nucleus	NFATC3	IDA		Human	PMID:18815128
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:18978355
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:17403661
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:14517551
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:23219532
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:9017603
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:16998587
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:20530871
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:12370307
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Mouse	PMID:16260608
Cellular Component	GO:0005634	nucleus	Nfatc3	IDA		Rat	PMID:15644446|RGD:1358616
Biological Process	GO:0001974	blood vessel remodeling	Nfatc3	IMP	MGI:MGI:2182778	Mouse	PMID:17403661
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Nfatc3	IGI	MGI:MGI:1920431	Mouse	PMID:11439183
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Nfatc3	IGI	MGI:MGI:107164	Mouse	PMID:18676376
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Nfatc3	IGI	MGI:MGI:107172	Mouse	PMID:19179536
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Nfatc3	IGI	MGI:MGI:107164	Mouse	PMID:12370307
Biological Process	GO:0045333	cellular respiration	Nfatc3	IMP	MGI:MGI:2182778	Mouse	PMID:12750314
Biological Process	GO:0071277	cellular response to calcium ion	Nfatc3	IDA		Mouse	PMID:23219532
Biological Process	GO:0071285	cellular response to lithium ion	Nfatc3	IDA		Mouse	PMID:20530871
Biological Process	GO:0007507	heart development	Nfatc3	IGI	MGI:MGI:1920431	Mouse	PMID:12750314
Biological Process	GO:0007507	heart development	Nfatc3	IGI	MGI:MGI:1920431	Mouse	PMID:17229811
Biological Process	GO:0014904	myotube cell development	Nfatc3	IMP		Mouse	PMID:18676376
Biological Process	GO:0014902	myotube differentiation	Nfatc3	IMP		Mouse	PMID:23206701
Biological Process	GO:1902894	negative regulation of miRNA transcription	NFATC3	IGI	UniProtKB:Q14934	Human	PMID:23543060
Biological Process	GO:1905064	negative regulation of vascular associated smooth muscle cell differentiation	NFATC3	IDA		Human	PMID:23853098
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nfatc3	IMP		Rat	PMID:15016802|RGD:1581961
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFATC3	IMP		Human	PMID:15173172
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFATC3	IDA		Human	PMID:18815128
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IGI	MGI:MGI:108067	Mouse	PMID:16998587
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IDA		Mouse	PMID:16998587
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IGI	MGI:MGI:107164	Mouse	PMID:17229811
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IDA		Mouse	PMID:17430895
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IDA		Mouse	PMID:10755616
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IGI	MGI:MGI:97275	Mouse	PMID:24301466
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc3	IGI	MGI:MGI:97275	Mouse	PMID:18676376
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nfatc3	IDA		Mouse	PMID:16260608
Biological Process	GO:2001256	regulation of store-operated calcium entry	Nfatc3	IMP		Mouse	PMID:23206701
Biological Process	GO:0001666	response to hypoxia	Nfatc3	IDA		Mouse	PMID:17403661
Biological Process	GO:0048741	skeletal muscle fiber development	Nfatc3	IMP	MGI:MGI:2182778	Mouse	PMID:11254352
Biological Process	GO:0030217	T cell differentiation	Nfatc3	IMP	MGI:MGI:2182778	Mouse	PMID:9768749
Biological Process	GO:0048538	thymus development	Nfatc3	IMP	MGI:MGI:2182778	Mouse	PMID:9768749
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc3	IGI	MGI:MGI:97275	Mouse	PMID:24301466
Biological Process	GO:0097084	vascular associated smooth muscle cell development	Nfatc3	IGI	MGI:MGI:1920431	Mouse	PMID:11439183
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	Nfatc3	IGI	MGI:MGI:1920431	Mouse	PMID:11439183

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern