Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nfatc4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NFATC4
- Mouse genes Nfatc4
- Rat genes Nfatc4
- Zfish genes nfatc4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfatc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nfatc4	IDA		Mouse	MGI:MGI:5295911\|PMID:21880741
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nfatc4	IDA		Mouse	PMID:12796475
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nfatc4	IMP		Rat	PMID:12954875\|RGD:1580247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Nfatc4	IDA		Mouse	PMID:17242187
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	NFATC4	IGI	UniProtKB:Q12968	Human	PMID:23543060
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nfatc4	IDA		Mouse	MGI:MGI:3624470\|PMID:16644691
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	Nfatc4	IPI	RGD:3371	Rat	PMID:18600431\|RGD:2301872
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	Nfatc4	IPI	RGD:3369	Rat	PMID:22198280\|RGD:5687133
Molecular Function	GO:0005515	protein binding	NFATC4	IPI	UniProtKB:Q86YM7	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC4	IPI	UniProtKB:Q9NSB8	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC4	IPI	UniProtKB:Q9NSC5	Human	PMID:18218901
Molecular Function	GO:0005515	protein binding	NFATC4	IPI	UniProtKB:P0CG48	Human	PMID:19026640
Molecular Function	GO:0005515	protein binding	NFATC4	IPI	UniProtKB:P46934	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Nfatc4	IPI	UniProtKB:Q60838\|UniProtKB:Q61062	Mouse	MGI:MGI:5295911\|PMID:21880741
Molecular Function	GO:0005515	protein binding	Nfatc4	IPI	UniProtKB:Q92997	Mouse	MGI:MGI:5295911\|PMID:21880741
Molecular Function	GO:0005515	protein binding	Nfatc4	IPI	UniProtKB:P51141	Mouse	MGI:MGI:5295911\|PMID:21880741
Molecular Function	GO:0005515	protein binding	Nfatc4	IPI	PR:Q91ZP3	Mouse	PMID:20385772
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc4	IDA		Mouse	MGI:MGI:3624470\|PMID:16644691
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc4	IDA		Mouse	PMID:12796475
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfatc4	IDA		Mouse	PMID:17242187
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFATC4	IDA		Human	PMID:28473536
Molecular Function	GO:0008134	transcription factor binding	Nfatc4	IDA		Mouse	PMID:19179536
Cellular Component	GO:0005737	cytoplasm	Nfatc4	IDA		Rat	PMID:15799720\|RGD:1580246
Cellular Component	GO:0005737	cytoplasm	Nfatc4	IDA		Rat	PMID:22343722\|RGD:13507305
Cellular Component	GO:0005829	cytosol	NFATC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Nfatc4	IDA		Mouse	MGI:MGI:5426290\|PMID:22586092
Cellular Component	GO:0005829	cytosol	Nfatc4	IDA		Mouse	PMID:16803872
Cellular Component	GO:0005829	cytosol	Nfatc4	IDA		Mouse	PMID:18354019
Cellular Component	GO:0005829	cytosol	Nfatc4	IDA		Mouse	PMID:17242187
Cellular Component	GO:0005829	cytosol	Nfatc4	IDA		Rat	PMID:15644446\|RGD:1358616
Cellular Component	GO:0016607	nuclear speck	NFATC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NFATC4	IDA		Human	PMID:12370307
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Mouse	MGI:MGI:5426290\|PMID:22586092
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Mouse	PMID:16803872
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Mouse	PMID:17242187
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Mouse	PMID:11439183
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Mouse	PMID:18354019
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Rat	PMID:15644446\|RGD:1358616
Cellular Component	GO:0005634	nucleus	Nfatc4	IDA		Rat	PMID:22343722\|RGD:13507305
Cellular Component	GO:0005667	transcription regulator complex	Nfatc4	IDA		Mouse	PMID:20385772
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Nfatc4	IMP		Mouse	MGI:MGI:5426290\|PMID:22586092
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Nfatc4	IGI	MGI:MGI:103296	Mouse	PMID:11439183
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Nfatc4	IGI	MGI:MGI:107172	Mouse	PMID:19179536
Biological Process	GO:0045333	cellular respiration	Nfatc4	IDA		Mouse	PMID:12750314
Biological Process	GO:1904637	cellular response to ionomycin	Nfatc4	IDA		Rat	PMID:21606195\|RGD:11561924
Biological Process	GO:0071285	cellular response to lithium ion	Nfatc4	IDA		Mouse	PMID:20530871
Biological Process	GO:0034644	cellular response to UV	Nfatc4	IGI	MGI:MGI:97583	Mouse	PMID:17242187
Biological Process	GO:0048813	dendrite morphogenesis	Nfatc4	IMP		Mouse	PMID:23407945
Biological Process	GO:0007507	heart development	Nfatc4	IGI	MGI:MGI:103296	Mouse	PMID:17229811
Biological Process	GO:0007507	heart development	Nfatc4	IGI	MGI:MGI:103296	Mouse	PMID:12750314
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Nfatc4	IMP		Mouse	PMID:17242187
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Nfatc4	IGI	MGI:MGI:97583	Mouse	PMID:17242187
Biological Process	GO:0007616	long-term memory	Nfatc4	IMP		Mouse	MGI:MGI:5426290\|PMID:22586092
Biological Process	GO:0060291	long-term synaptic potentiation	Nfatc4	IMP		Mouse	MGI:MGI:5426290\|PMID:22586092
Biological Process	GO:0035562	negative regulation of chromatin binding	Nfatc4	IDA		Mouse	PMID:23407945
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	Nfatc4	IMP		Mouse	PMID:23407945
Biological Process	GO:1902894	negative regulation of miRNA transcription	NFATC4	IGI	UniProtKB:Q12968	Human	PMID:23543060
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Nfatc4	IMP		Mouse	MGI:MGI:5426290\|PMID:22586092
Biological Process	GO:0032091	negative regulation of protein binding	Nfatc4	IDA		Mouse	MGI:MGI:5295911\|PMID:21880741
Biological Process	GO:2000297	negative regulation of synapse maturation	Nfatc4	IMP		Mouse	PMID:23407945
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfatc4	IDA		Mouse	MGI:MGI:5295911\|PMID:21880741
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nfatc4	IDA		Mouse	MGI:MGI:3624470\|PMID:16644691
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Nfatc4	IDA		Mouse	MGI:MGI:5295911\|PMID:21880741
Biological Process	GO:0051402	neuron apoptotic process	Nfatc4	IMP		Mouse	PMID:18354019
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Nfatc4	IMP		Mouse	PMID:20530871
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Nfatc4	IMP		Mouse	PMID:18354019
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IGI	MGI:MGI:98358	Mouse	PMID:19179536
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IDA		Mouse	PMID:16803872
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IDA		Mouse	PMID:20385772
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IMP		Mouse	PMID:18354019
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IDA		Mouse	PMID:17430895
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IGI	UniProtKB:P01375	Mouse	PMID:16803872
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfatc4	IMP		Mouse	PMID:17242187
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nfatc4	IMP		Mouse	PMID:17242187
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nfatc4	IDA		Mouse	PMID:12796475
Biological Process	GO:0048167	regulation of synaptic plasticity	Nfatc4	IMP		Rat	PMID:12954875\|RGD:1580247
Biological Process	GO:0060074	synapse maturation	Nfatc4	IMP		Mouse	PMID:23407945
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc4	IMP		Mouse	PMID:17242187
Biological Process	GO:0006366	transcription by RNA polymerase II	Nfatc4	IMP		Mouse	PMID:18354019
Biological Process	GO:0032640	tumor necrosis factor production	Nfatc4	IMP		Mouse	PMID:17242187
Biological Process	GO:0097084	vascular associated smooth muscle cell development	Nfatc4	IGI	MGI:MGI:103296	Mouse	PMID:11439183
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	Nfatc4	IGI	MGI:MGI:103296	Mouse	PMID:11439183

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.