Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFE2
  • Mouse genes Nfe2
  • Rat genes Nfe2
  • Zfish genes nfe2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfe2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	NFE2	IDA		Human	PMID:16263792
Molecular Function	GO:0003677	DNA binding	NFE2	IDA		Human	PMID:12609092
Molecular Function	GO:0003677	DNA binding	nfe2	IPI	UniProtKB:Q6NW89	Zfish	PMID:15207702
Molecular Function	GO:0003677	DNA binding	nfe2	IPI	UniProtKB:Q7T3H0	Zfish	PMID:15207702
Molecular Function	GO:0003677	DNA binding	nfe2	IPI	UniProtKB:Q6I6N2	Zfish	PMID:15207702
Molecular Function	GO:0003677	DNA binding	nfe2	IPI	UniProtKB:Q6I6N0	Zfish	PMID:15207702
Molecular Function	GO:0042802	identical protein binding	NFE2	IPI	UniProtKB:Q16621	Human	PMID:20102225
Molecular Function	GO:0042802	identical protein binding	NFE2	IPI	UniProtKB:Q16621	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:O75381	Human	PMID:11863372
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q9DGW5	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q9Y4A8	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q9Y4A8	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q9Y297	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q53GS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NFE2	IPI	UniProtKB:Q9Y649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nfe2	IPI	UniProtKB:P79621	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Nfe2	IPI	UniProtKB:Q9Z148-1	Mouse	MGI:MGI:4366183|PMID:19822740
Molecular Function	GO:0005515	protein binding	Nfe2	IPI	PR:P45481	Mouse	PMID:21558372
Molecular Function	GO:0046982	protein heterodimerization activity	nfe2	IPI	UniProtKB:Q7T3H0	Zfish	PMID:15207702
Molecular Function	GO:0046982	protein heterodimerization activity	nfe2	IPI	UniProtKB:Q6I6N2	Zfish	PMID:15207702
Molecular Function	GO:0046982	protein heterodimerization activity	nfe2	IPI	UniProtKB:Q6NW89	Zfish	PMID:15207702
Molecular Function	GO:0046982	protein heterodimerization activity	nfe2	IPI	UniProtKB:Q6I6N0	Zfish	PMID:15207702
Molecular Function	GO:0043565	sequence-specific DNA binding	nfe2	IPI	UniProtKB:Q61827	Zfish	PMID:12388799
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFE2	IDA		Human	PMID:28473536
Molecular Function	GO:0050699	WW domain binding	NFE2	IDA		Human	PMID:9305852
Molecular Function	GO:0050699	WW domain binding	NFE2	IPI	UniProtKB:P46934	Human	PMID:9305852
Molecular Function	GO:0050699	WW domain binding	NFE2	IPI	UniProtKB:P46937	Human	PMID:9305852
Cellular Component	GO:0005634	nucleus	Nfe2	IDA		Mouse	PMID:7995373
Cellular Component	GO:0032993	protein-DNA complex	NFE2	IDA		Human	PMID:12609092
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NFE2	IPI		Human	PMID:20102225
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NFE2	IPI		Human	PMID:23661758
Cellular Component	GO:0005667	transcription regulator complex	nfe2	IDA		Zfish	PMID:15207702
Cellular Component	GO:0005667	transcription regulator complex	nfe2	IDA		Zfish	PMID:12388799
Biological Process	GO:0007596	blood coagulation	nfe2	IGI	ZFIN:ZDB-GENO-200528-10	Zfish	PMID:30663848
Biological Process	GO:0030282	bone mineralization	Nfe2	IMP	MGI:MGI:1857224	Mouse	PMID:15005853
Biological Process	GO:0008283	cell population proliferation	Nfe2	IDA		Mouse	PMID:11113182
Biological Process	GO:0007267	cell-cell signaling	Nfe2	IMP	MGI:MGI:1857224	Mouse	PMID:15005853
Biological Process	GO:0010467	gene expression	Nfe2	IMP		Mouse	PMID:28411267
Biological Process	GO:0010467	gene expression	Nfe2	IDA		Mouse	PMID:28411267
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Nfe2	IMP	MGI:MGI:1857224	Mouse	PMID:21558372
Biological Process	GO:0030502	negative regulation of bone mineralization	Nfe2	IMP	MGI:MGI:1857224	Mouse	PMID:15005853
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nfe2	IDA		Mouse	PMID:11113182
Biological Process	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion	Nfe2	IGI	MGI:MGI:108045	Mouse	PMID:21558372
Biological Process	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion	Nfe2	IMP		Mouse	PMID:21558372
Biological Process	GO:0071600	otic vesicle morphogenesis	nfe2	IMP	ZFIN:ZDB-MRPHLNO-140224-8	Zfish	PMID:24298298
Biological Process	GO:2000758	positive regulation of peptidyl-lysine acetylation	Nfe2	IMP	MGI:MGI:1857224	Mouse	PMID:21558372
Biological Process	GO:0010468	regulation of gene expression	Nfe2	IDA		Mouse	PMID:11113182
Biological Process	GO:0010725	regulation of primitive erythrocyte differentiation	nfe2	IMP	ZFIN:ZDB-GENO-170601-3	Zfish	PMID:27716579
Biological Process	GO:1902882	regulation of response to oxidative stress	nfe2	IMP	ZFIN:ZDB-GENO-170601-3	Zfish	PMID:27716579
Biological Process	GO:0048798	swim bladder inflation	nfe2	IMP	ZFIN:ZDB-MRPHLNO-140224-9	Zfish	PMID:24298298
Biological Process	GO:0048798	swim bladder inflation	nfe2	IMP	ZFIN:ZDB-MRPHLNO-140224-8	Zfish	PMID:24298298
Biological Process	GO:0000768	syncytium formation by plasma membrane fusion	Nfe2	IGI	MGI:MGI:108045	Mouse	PMID:21558372
Biological Process	GO:0000768	syncytium formation by plasma membrane fusion	Nfe2	IMP		Mouse	PMID:21558372

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern