Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nfe2l1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NFE2L1
- Mouse genes Nfe2l1
- Rat genes Nfe2l1
- Zfish genes nfe2l1a,nfe2l1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfe2l1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	Nfe2l1	IDA		Mouse	PMID:29149604
Molecular Function	GO:0003682	chromatin binding	Nfe2l1	IDA		Mouse	PMID:25637874
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfe2l1	IDA		Mouse	MGI:MGI:6107583\|PMID:11342101
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfe2l1	IDA		Mouse	MGI:MGI:6316451\|PMID:10601325
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfe2l1	IDA		Mouse	MGI:MGI:4820675\|PMID:20385086
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfe2l1	IDA		Mouse	MGI:MGI:1332311\|PMID:10037736
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfe2l1	IMP		Mouse	MGI:MGI:5432848\|PMID:22586274
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nfe2l1	IDA		Mouse	MGI:MGI:6101031\|PMID:29149604
Molecular Function	GO:0042802	identical protein binding	NFE2L1	IPI	UniProtKB:Q14494	Human	PMID:20102225
Molecular Function	GO:0042802	identical protein binding	NFE2L1	IPI	UniProtKB:Q14494	Human	PMID:23661758
Molecular Function	GO:1990841	promoter-specific chromatin binding	Nfe2l1	IDA		Mouse	PMID:25637874
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:O15525	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:Q9NS37	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:Q14145	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:O15525	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:Q9NS37	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:Q9ULX9	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:A0A0C5B5G6	Human	PMID:29983246
Molecular Function	GO:0005515	protein binding	NFE2L1	IPI	UniProtKB:Q14145	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Nfe2l1	IPI	UniProtKB:O54790	Mouse	MGI:MGI:6107583\|PMID:11342101
Molecular Function	GO:0005515	protein binding	Nfe2l1	IPI	UniProtKB:Q3ULA2\|UniProtKB:Q9DBY1	Mouse	MGI:MGI:5299399\|PMID:21911472
Molecular Function	GO:0005515	protein binding	Nfe2l1	IPI	UniProtKB:Q8VBV4	Mouse	MGI:MGI:6107392\|PMID:21953459
Molecular Function	GO:0005515	protein binding	Nfe2l1	IPI	PR:Q9Z2B5	Mouse	PMID:14517290
Molecular Function	GO:0019904	protein domain specific binding	Nfe2l1	IPI	UniProtKB:Q9Z2X8	Mouse	MGI:MGI:5882890\|PMID:16581765
Molecular Function	GO:0044877	protein-containing complex binding	Nfe2l1	IDA		Mouse	MGI:MGI:5882890\|PMID:16581765
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfe2l1	IDA		Mouse	MGI:MGI:6316451\|PMID:10601325
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfe2l1	IDA		Mouse	MGI:MGI:4820675\|PMID:20385086
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfe2l1	IDA		Mouse	MGI:MGI:6107583\|PMID:11342101
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfe2l1	IDA		Mouse	MGI:MGI:1332311\|PMID:10037736
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfe2l1	IMP		Mouse	MGI:MGI:5432848\|PMID:22586274
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfe2l1	IDA		Mouse	MGI:MGI:6101031\|PMID:29149604
Cellular Component	GO:0005829	cytosol	NFE2L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	Nfe2l1	IDA		Mouse	PMID:29400713
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Nfe2l1	IDA		Mouse	PMID:29149604
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Nfe2l1	IDA		Mouse	PMID:25290918
Cellular Component	GO:0005654	nucleoplasm	NFE2L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nfe2l1	IDA		Mouse	MGI:MGI:6101031\|PMID:29149604
Cellular Component	GO:0032991	protein-containing complex	Nfe2l1	IDA		Mouse	MGI:MGI:5882890\|PMID:16581765
Biological Process	GO:0045454	cell redox homeostasis	Nfe2l1	IDA		Mouse	MGI:MGI:6107583\|PMID:11342101
Biological Process	GO:0045454	cell redox homeostasis	Nfe2l1	IDA		Mouse	MGI:MGI:6316451\|PMID:10601325
Biological Process	GO:0019725	cellular homeostasis	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29400713
Biological Process	GO:0071397	cellular response to cholesterol	Nfe2l1	IDA		Mouse	MGI:MGI:6101031\|PMID:29149604
Biological Process	GO:0071397	cellular response to cholesterol	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29149604
Biological Process	GO:0070417	cellular response to cold	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29400713
Biological Process	GO:0071280	cellular response to copper ion	Nfe2l1	IMP	MGI:MGI:2385929	Mouse	PMID:24462598
Biological Process	GO:0034599	cellular response to oxidative stress	Nfe2l1	IDA		Mouse	MGI:MGI:4820675\|PMID:20385086
Biological Process	GO:0034599	cellular response to oxidative stress	Nfe2l1	IDA		Mouse	MGI:MGI:6107583\|PMID:11342101
Biological Process	GO:0034599	cellular response to oxidative stress	Nfe2l1	IDA		Mouse	MGI:MGI:6316451\|PMID:10601325
Biological Process	GO:0042632	cholesterol homeostasis	Nfe2l1	IDA		Mouse	MGI:MGI:6101031\|PMID:29149604
Biological Process	GO:0042632	cholesterol homeostasis	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29149604
Biological Process	GO:0042883	cysteine transport	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:25092871
Biological Process	GO:0030218	erythrocyte differentiation	Nfe2l1	IMP	MGI:MGI:2385929	Mouse	PMID:9501099
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Nfe2l1	IMP	MGI:MGI:5804004	Mouse	PMID:25041126
Biological Process	GO:0021781	glial cell fate commitment	Nfe2l1	IDA		Mouse	PMID:23840004
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Nfe2l1	IMP	MGI:MGI:5804004	Mouse	PMID:25041126
Biological Process	GO:0006749	glutathione metabolic process	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:25092871
Biological Process	GO:0055088	lipid homeostasis	Nfe2l1	IMP		Mouse	MGI:MGI:5432848\|PMID:22586274
Biological Process	GO:0000089	mitotic metaphase	Nfe2l1	IMP		Mouse	PMID:22971132
Biological Process	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	Nfe2l1	IDA		Mouse	MGI:MGI:6101031\|PMID:29149604
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfe2l1	IDA		Mouse	MGI:MGI:1332311\|PMID:10037736
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfe2l1	IDA		Mouse	MGI:MGI:6316451\|PMID:10601325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfe2l1	IDA		Mouse	MGI:MGI:6107583\|PMID:11342101
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfe2l1	IMP	MGI:MGI:2385929	Mouse	PMID:24462598
Biological Process	GO:0000209	protein polyubiquitination	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:21554501
Biological Process	GO:0019217	regulation of fatty acid metabolic process	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:25092871
Biological Process	GO:0010468	regulation of gene expression	Nfe2l1	IMP	MGI:MGI:5804004	Mouse	PMID:25041126
Biological Process	GO:0010468	regulation of gene expression	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:25092871
Biological Process	GO:0010468	regulation of gene expression	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:28088524
Biological Process	GO:0010906	regulation of glucose metabolic process	Nfe2l1	IMP	MGI:MGI:5804004	Mouse	PMID:25041126
Biological Process	GO:0050727	regulation of inflammatory response	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29149604
Biological Process	GO:0050727	regulation of inflammatory response	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29400713
Biological Process	GO:0019216	regulation of lipid metabolic process	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:25092871
Biological Process	GO:0007088	regulation of mitotic nuclear division	Nfe2l1	IMP		Mouse	PMID:22971132
Biological Process	GO:1903353	regulation of nucleus organization	Nfe2l1	IMP		Mouse	PMID:22971132
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29400713
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:27920251
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	Nfe2l1	IMP	MGI:MGI:6101514	Mouse	PMID:29400713
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IDA		Mouse	MGI:MGI:4820675\|PMID:20385086
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:27920251
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IMP		Mouse	PMID:25290918
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IMP		Mouse	PMID:22971132
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IMP		Mouse	PMID:25637874
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IDA		Mouse	PMID:25637874
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nfe2l1	IMP	MGI:MGI:2385929	Mouse	PMID:23702335
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Nfe2l1	IDA		Mouse	PMID:25637874
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Nfe2l1	IMP	MGI:MGI:2385929	Mouse	PMID:23702335
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Nfe2l1	IMP	MGI:MGI:3828165	Mouse	PMID:21554501

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.