Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NFIB
  • Mouse genes Nfib
  • Rat genes Nfib
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nfib

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	NFIB	IDA		Human	PMID:19540848
Molecular Function	GO:0003677	DNA binding	NFIB	IDA		Human	PMID:9099724
Molecular Function	GO:0003677	DNA binding	Nfib	IDA		Rat	PMID:10432316|RGD:61671
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NFIB	IDA		Human	PMID:19540848
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfib	IDA		Mouse	MGI:MGI:5049839|PMID:21513708
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nfib	IMP		Mouse	MGI:MGI:5284771|PMID:17904922
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NFIB	IDA		Human	PMID:19540848
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NFIB	IDA		Human	PMID:9099724
Molecular Function	GO:0003690	double-stranded DNA binding	Nfib	IDA		Rat	PMID:10521600|RGD:633408
Molecular Function	GO:0005515	protein binding	NFIB	IPI	UniProtKB:P08651	Human	PMID:25258084
Molecular Function	GO:0005515	protein binding	NFIB	IPI	UniProtKB:P08651	Human	PMID:35140242
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFIB	IDA		Human	PMID:19540848
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nfib	IDA		Mouse	PMID:29106906
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NFIB	IDA		Human	PMID:28473536
Cellular Component	GO:0044300	cerebellar mossy fiber	Nfib	IDA		Mouse	MGI:MGI:5284754|PMID:19107796
Cellular Component	GO:0001650	fibrillar center	NFIB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NFIB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NFIB	IDA		Human	PMID:9099724
Cellular Component	GO:0005634	nucleus	Nfib	IDA		Mouse	MGI:MGI:5049839|PMID:21513708
Cellular Component	GO:0005634	nucleus	Nfib	IDA		Mouse	PMID:25403566
Biological Process	GO:0021960	anterior commissure morphogenesis	Nfib	IMP		Mouse	MGI:MGI:4453290|PMID:19961580
Biological Process	GO:0007420	brain development	NFIB	IMP		Human	PMID:30388402
Biological Process	GO:0060689	cell differentiation involved in salivary gland development	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:25403566
Biological Process	GO:0008283	cell population proliferation	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:15632069
Biological Process	GO:0021846	cell proliferation in forebrain	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:27965439
Biological Process	GO:0044838	cell quiescence	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:33004674
Biological Process	GO:0002062	chondrocyte differentiation	Nfib	IMP		Mouse	MGI:MGI:5284771|PMID:17904922
Biological Process	GO:0060486	club cell differentiation	Nfib	IMP		Mouse	MGI:MGI:5049839|PMID:21513708
Biological Process	GO:0071679	commissural neuron axon guidance	Nfib	IMP		Mouse	MGI:MGI:4453290|PMID:19961580
Biological Process	GO:0010458	exit from mitosis	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0030900	forebrain development	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:15632069
Biological Process	GO:0010467	gene expression	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:29106906
Biological Process	GO:0010467	gene expression	Nfib	IGI	MGI:MGI:103188	Mouse	PMID:29106906
Biological Process	GO:0010467	gene expression	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0010467	gene expression	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:32393888
Biological Process	GO:0048699	generation of neurons	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:33004674
Biological Process	GO:0002067	glandular epithelial cell differentiation	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:25403566
Biological Process	GO:0010001	glial cell differentiation	Nfib	IMP		Mouse	MGI:MGI:4453290|PMID:19961580
Biological Process	GO:0021780	glial cell fate specification	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0014009	glial cell proliferation	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0014009	glial cell proliferation	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:33004674
Biological Process	GO:0030902	hindbrain development	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:15632069
Biological Process	GO:0061141	lung ciliated cell differentiation	Nfib	IMP		Mouse	MGI:MGI:5049839|PMID:21513708
Biological Process	GO:0030324	lung development	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:15632069
Biological Process	GO:0030324	lung development	Nfib	IMP	MGI:MGI:2178748	Mouse	PMID:11850179
Biological Process	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis	Nfib	IMP		Mouse	MGI:MGI:5049839|PMID:21513708
Biological Process	GO:2000791	negative regulation of mesenchymal cell proliferation involved in lung development	Nfib	IMP		Mouse	MGI:MGI:5049839|PMID:21513708
Biological Process	GO:1902894	negative regulation of miRNA transcription	NFIB	IMP		Human	PMID:18384814
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:15632069
Biological Process	GO:0061351	neural precursor cell proliferation	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0022008	neurogenesis	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0048665	neuron fate specification	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NFIB	IDA		Human	PMID:30388402
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nfib	IDA		Rat	PMID:10432316|RGD:61671
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFIB	IDA		Human	PMID:19540848
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NFIB	IDA		Human	PMID:9099724
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfib	IMP		Mouse	MGI:MGI:5284771|PMID:17904922
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfib	IDA		Mouse	MGI:MGI:4461125|PMID:19706729
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfib	IDA		Mouse	MGI:MGI:5049839|PMID:21513708
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nfib	IDA		Mouse	PMID:9056636
Biological Process	GO:0021740	principal sensory nucleus of trigeminal nerve development	Nfib	IMP		Mouse	MGI:MGI:5284754|PMID:19107796
Biological Process	GO:0031099	regeneration	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:32393888
Biological Process	GO:0009617	response to bacterium	Nfib	IEP		Mouse	PMID:23012479
Biological Process	GO:0009611	response to wounding	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:33004674
Biological Process	GO:0060041	retina development in camera-type eye	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:31128945
Biological Process	GO:0060662	salivary gland cavitation	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:25403566
Biological Process	GO:0019827	stem cell population maintenance	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:32393888
Biological Process	GO:0072089	stem cell proliferation	Nfib	IMP	MGI:MGI:3530139	Mouse	PMID:15632069
Biological Process	GO:0001894	tissue homeostasis	Nfib	IMP	MGI:MGI:5052268	Mouse	PMID:32393888
Biological Process	GO:0060509	type I pneumocyte differentiation	Nfib	IMP		Mouse	MGI:MGI:5049839|PMID:21513708
Biological Process	GO:0060510	type II pneumocyte differentiation	Nfib	IMP		Mouse	MGI:MGI:5049839|PMID:21513708

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern