Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NHEJ1
  • Mouse genes Nhej1
  • Rat genes Nhej1
  • Zfish genes nhej1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nhej1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045027	DNA end binding	NHEJ1	IDA		Human	PMID:18158905
Molecular Function	GO:0070182	DNA polymerase binding	NHEJ1	IPI	UniProtKB:Q9UGP5	Human	PMID:30250067
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:P49917	Human	PMID:16439205
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:16439205
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:18064046
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:18158905
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:21349273
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:P12956	Human	PMID:24095731
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:27437582
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:28500754
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:P49917	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	NHEJ1	IPI	UniProtKB:Q13426	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	Nhej1	IPI	UniProtKB:Q8BHZ5	Mouse	MGI:MGI:6202149|PMID:30017584
Cellular Component	GO:0001650	fibrillar center	NHEJ1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070419	nonhomologous end joining complex	NHEJ1	IDA		Human	PMID:20383123
Cellular Component	GO:0070419	nonhomologous end joining complex	NHEJ1	IDA		Human	PMID:25941166
Cellular Component	GO:0005654	nucleoplasm	NHEJ1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NHEJ1	IDA		Human	PMID:20558749
Cellular Component	GO:0005634	nucleus	NHEJ1	IDA		Human	PMID:16439204
Cellular Component	GO:0005634	nucleus	NHEJ1	IDA		Human	PMID:16439205
Cellular Component	GO:0035861	site of double-strand break	NHEJ1	IDA		Human	PMID:18064046
Cellular Component	GO:0035861	site of double-strand break	NHEJ1	IDA		Human	PMID:18644470
Cellular Component	GO:0035861	site of double-strand break	NHEJ1	IDA		Human	PMID:27437582
Cellular Component	GO:0035861	site of double-strand break	NHEJ1	IDA		Human	PMID:28500754
Biological Process	GO:0030183	B cell differentiation	NHEJ1	IMP		Human	PMID:16439204
Biological Process	GO:0051103	DNA ligation involved in DNA repair	NHEJ1	IDA		Human	PMID:19056826
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IMP		Human	PMID:16439204
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IMP		Human	PMID:16439205
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:17717001
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:18158905
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:18644470
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:19056826
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:20558749
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:27437582
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:28500754
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NHEJ1	IDA		Human	PMID:30250067
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Nhej1	IMP		Mouse	MGI:MGI:5807276|PMID:27798842
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Nhej1	IMP		Mouse	MGI:MGI:5822993|PMID:28051062
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	NHEJ1	IDA		Human	PMID:20558749
Biological Process	GO:0010212	response to ionizing radiation	NHEJ1	IDA		Human	PMID:16439205
Biological Process	GO:0030217	T cell differentiation	NHEJ1	IMP		Human	PMID:16439204

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern