Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NHLH2
  • Mouse genes Nhlh2
  • Rat genes Nhlh2
  • Zfish genes nhlh2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nhlh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nhlh2	IDA		Mouse	MGI:MGI:3056835|PMID:15470499
Molecular Function	GO:0005515	protein binding	NHLH2	IPI	UniProtKB:Q96EB6	Human	PMID:22169038
Molecular Function	GO:0005515	protein binding	NHLH2	IPI	UniProtKB:P13349	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NHLH2	IPI	UniProtKB:P15884-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NHLH2	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NHLH2	IPI	UniProtKB:Q9H5J8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NHLH2	IPI	UniProtKB:Q9NZI2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nhlh2	IPI	UniProtKB:Q923E4	Mouse	MGI:MGI:5302137|PMID:22169038
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nhlh2	IDA		Mouse	MGI:MGI:3056835|PMID:15470499
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nhlh2	IDA		Mouse	MGI:MGI:3795052|PMID:18356286
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	NHLH2	IPI	UniProtKB:P25791	Human	PMID:16314316
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Nhlh2	IPI	UniProtKB:P42227	Mouse	MGI:MGI:3795052|PMID:18356286
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NHLH2	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	Nhlh2	IDA		Mouse	MGI:MGI:3795052|PMID:18356286
Biological Process	GO:0006915	apoptotic process	Nhlh2	IGI	UniProtKB:Q02576	Mouse	MGI:MGI:3723363|PMID:17573818
Biological Process	GO:0021535	cell migration in hindbrain	Nhlh2	IGI	UniProtKB:Q02576	Mouse	MGI:MGI:3723363|PMID:17573818
Biological Process	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	Nhlh2	IMP		Mouse	MGI:MGI:5504302|PMID:23785158
Biological Process	GO:0008584	male gonad development	Nhlh2	IMP		Mouse	MGI:MGI:86739|PMID:9090387
Biological Process	GO:0060179	male mating behavior	Nhlh2	IMP		Mouse	MGI:MGI:86739|PMID:9090387
Biological Process	GO:0042698	ovulation cycle	Nhlh2	IMP	MGI:MGI:2180391	Mouse	PMID:15465527
Biological Process	GO:0007422	peripheral nervous system development	Nhlh2	IMP		Mouse	MGI:MGI:3847049|PMID:19436734
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nhlh2	IDA		Mouse	MGI:MGI:3795052|PMID:18356286
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nhlh2	IDA		Mouse	MGI:MGI:3056835|PMID:15470499

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern