Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NIPBL
  • Mouse genes Nipbl
  • Rat genes Nipbl
  • Zfish genes nipbla,nipblb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nipbl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nipbl	IDA		Mouse	PMID:20720539
Molecular Function	GO:0140587	chromatin loop anchoring activity	nipblb	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Molecular Function	GO:0140587	chromatin loop anchoring activity	nipblb	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Molecular Function	GO:0140587	chromatin loop anchoring activity	nipbla	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Molecular Function	GO:0140587	chromatin loop anchoring activity	nipbla	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Molecular Function	GO:0070087	chromo shadow domain binding	NIPBL	IPI	UniProtKB:P45973	Human	PMID:15882967
Molecular Function	GO:0061775	cohesin loader activity	NIPBL	IMP		Human	PMID:22628566
Molecular Function	GO:0061775	cohesin loader activity	Nipbl	IMP		Mouse	MGI:MGI:6102971|PMID:29094699
Molecular Function	GO:0042826	histone deacetylase binding	NIPBL	IPI	UniProtKB:O15379	Human	PMID:18854353
Molecular Function	GO:0042826	histone deacetylase binding	NIPBL	IPI	UniProtKB:Q13547	Human	PMID:18854353
Molecular Function	GO:0036033	mediator complex binding	Nipbl	IDA		Mouse	PMID:20720539
Molecular Function	GO:1990841	promoter-specific chromatin binding	Nipbl	IDA		Mouse	MGI:MGI:5908762|PMID:28041881
Molecular Function	GO:0005515	protein binding	NIPBL	IPI	UniProtKB:Q9Y6X3	Human	PMID:16682347
Molecular Function	GO:0005515	protein binding	NIPBL	IPI	UniProtKB:Q9Y6X3	Human	PMID:16802858
Molecular Function	GO:0005515	protein binding	NIPBL	IPI	UniProtKB:Q9BQA5	Human	PMID:17577209
Molecular Function	GO:0005515	protein binding	NIPBL	IPI	UniProtKB:Q9Y6X3	Human	PMID:21934712
Molecular Function	GO:0005515	protein binding	NIPBL	IPI	UniProtKB:Q9Y6X3	Human	PMID:22628566
Molecular Function	GO:0005515	protein binding	NIPBL	IPI	UniProtKB:Q9Y6X3	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	Nipbl	IPI	UniProtKB:Q8BZ47	Mouse	MGI:MGI:5908762|PMID:28041881
Cellular Component	GO:0000785	chromatin	Nipbl	IDA		Mouse	PMID:23920377
Cellular Component	GO:0005829	cytosol	NIPBL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	NIPBL	HDA		Human	PMID:19056867
Cellular Component	GO:0032039	integrator complex	Nipbl	IDA		Mouse	MGI:MGI:5908762|PMID:28041881
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NIPBL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NIPBL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NIPBL	IDA		Human	PMID:16802858
Cellular Component	GO:0005634	nucleus	Nipbl	IDA		Mouse	MGI:MGI:6102971|PMID:29094699
Cellular Component	GO:0090694	Scc2-Scc4 cohesin loading complex	NIPBL	IDA		Human	PMID:22628566
Cellular Component	GO:0032116	SMC loading complex	NIPBL	IDA		Human	PMID:16682347
Biological Process	GO:0007420	brain development	NIPBL	IMP		Human	PMID:8291537
Biological Process	GO:0071481	cellular response to X-ray	NIPBL	IMP		Human	PMID:17468178
Biological Process	GO:0007417	central nervous system development	nipblb	IMP	ZFIN:ZDB-MRPHLNO-131219-3	Zfish	PMID:24136230
Biological Process	GO:0050890	cognition	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:0048589	developmental growth	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:0048589	developmental growth	nipblb	IGI	ZFIN:ZDB-MRPHLNO-131219-3,ZFIN:ZDB-MRPHLNO-160407-3	Zfish	PMID:26206533
Biological Process	GO:0048565	digestive tract development	nipblb	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0048565	digestive tract development	nipbla	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0006974	DNA damage response	NIPBL	IMP		Human	PMID:17468178
Biological Process	GO:0042471	ear morphogenesis	NIPBL	IMP		Human	PMID:8291537
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:19763162
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	NIPBL	IMP		Human	PMID:8291537
Biological Process	GO:0035115	embryonic forelimb morphogenesis	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0035115	embryonic forelimb morphogenesis	NIPBL	IMP		Human	PMID:8291537
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	nipblb	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	nipblb	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	nipbla	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	nipbla	IGI	ZFIN:ZDB-MRPHLNO-080819-1,ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25255084
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:19763162
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nipblb	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25378554
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nipbla	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:25378554
Biological Process	GO:0035261	external genitalia morphogenesis	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:0035261	external genitalia morphogenesis	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0048592	eye morphogenesis	NIPBL	IMP		Human	PMID:8291537
Biological Process	GO:0060325	face morphogenesis	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:0060325	face morphogenesis	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0045444	fat cell differentiation	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:19763162
Biological Process	GO:0035136	forelimb morphogenesis	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:0061010	gallbladder development	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0007507	heart development	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:19763162
Biological Process	GO:0007507	heart development	nipblb	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0007507	heart development	nipbla	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0007507	heart development	nipbla	IMP	ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0003146	heart jogging	nipblb	IGI	ZFIN:ZDB-MRPHLNO-111201-1,ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0003146	heart jogging	nipbla	IMP	ZFIN:ZDB-MRPHLNO-111201-3	Zfish	PMID:22039349
Biological Process	GO:0003007	heart morphogenesis	NIPBL	IMP		Human	PMID:8291537
Biological Process	GO:0034088	maintenance of mitotic sister chromatid cohesion	NIPBL	IMP		Human	PMID:16682347
Biological Process	GO:0007064	mitotic sister chromatid cohesion	NIPBL	IMP		Human	PMID:16100726
Biological Process	GO:0007064	mitotic sister chromatid cohesion	NIPBL	IDA		Human	PMID:22628566
Biological Process	GO:0000070	mitotic sister chromatid segregation	Nipbl	IMP		Mouse	MGI:MGI:6102971|PMID:29094699
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NIPBL	IDA		Human	PMID:18854353
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NIPBL	IDA		Human	PMID:18854353
Biological Process	GO:0070050	neuron cellular homeostasis	nipblb	IMP	ZFIN:ZDB-MRPHLNO-131219-3	Zfish	PMID:26206533
Biological Process	GO:0003151	outflow tract morphogenesis	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0031065	positive regulation of histone deacetylation	NIPBL	IDA		Human	PMID:18854353
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:19763162
Biological Process	GO:2001224	positive regulation of neuron migration	Nipbl	IMP		Mouse	MGI:MGI:5908762|PMID:28041881
Biological Process	GO:0045778	positive regulation of ossification	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:19763162
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nipbl	IMP	MGI:MGI:4332250	Mouse	PMID:23920377
Biological Process	GO:0008104	protein localization	NIPBL	IMP		Human	PMID:17468178
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	nipblb	IMP	ZFIN:ZDB-MRPHLNO-131219-3	Zfish	PMID:24136230
Biological Process	GO:0048638	regulation of developmental growth	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0045995	regulation of embryonic development	NIPBL	IMP		Human	PMID:19242925
Biological Process	GO:0042634	regulation of hair cycle	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:1903706	regulation of hemopoiesis	nipblb	IMP	ZFIN:ZDB-MRPHLNO-131219-3	Zfish	PMID:32323916
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nipbl	IMP		Mouse	MGI:MGI:5908762|PMID:28041881
Biological Process	GO:0007605	sensory perception of sound	NIPBL	IMP		Human	PMID:15146186
Biological Process	GO:0035019	somatic stem cell population maintenance	Nipbl	IMP		Mouse	PMID:20720539
Biological Process	GO:0061038	uterus morphogenesis	NIPBL	IMP		Human	PMID:19242925

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern