Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX2-3
  • Mouse genes Nkx2-3
  • Rat genes Nkx2-3
  • Zfish genes nkx2.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx2-3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NKX2-3	IDA		Human	PMID:28473536
Biological Process	GO:0030183	B cell differentiation	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:12682228
Biological Process	GO:0043367	CD4-positive, alpha-beta T cell differentiation	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0048565	digestive tract development	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10207146
Biological Process	GO:0048565	digestive tract development	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0022612	gland morphogenesis	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0006955	immune response	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:12682228
Biological Process	GO:0001776	leukocyte homeostasis	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0050900	leukocyte migration	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0050900	leukocyte migration	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10790368
Biological Process	GO:0048535	lymph node development	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0048535	lymph node development	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10790368
Biological Process	GO:0030225	macrophage differentiation	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0048537	mucosa-associated lymphoid tissue development	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:12141427
Biological Process	GO:0048541	Peyer's patch development	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10790368
Biological Process	GO:0002317	plasma cell differentiation	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-3	IDA		Mouse	PMID:10790368
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0009791	post-embryonic development	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0048621	post-embryonic digestive tract morphogenesis	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10207146
Biological Process	GO:0048536	spleen development	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0048536	spleen development	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10790368
Biological Process	GO:0048536	spleen development	Nkx2-3	IMP	MGI:MGI:2386680	Mouse	PMID:10207146
Biological Process	GO:0006366	transcription by RNA polymerase II	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756
Biological Process	GO:0006641	triglyceride metabolic process	Nkx2-3	IMP	MGI:MGI:2448069	Mouse	PMID:10926756

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern