Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX2-4
  • Mouse genes Nkx2-4
  • Rat genes Nkx2-4
  • Zfish genes nkx2.4a,nkx2.4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx2-4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NKX2-4	IPI	UniProtKB:A8MTQ0	Human	PMID:32296183
Biological Process	GO:0021854	hypothalamus development	nkx2.4b	IGI	ZFIN:ZDB-MRPHLNO-091013-2,ZFIN:ZDB-MRPHLNO-150407-1	Zfish	PMID:25520628
Biological Process	GO:0021854	hypothalamus development	nkx2.4b	IGI	ZFIN:ZDB-MRPHLNO-091013-2,ZFIN:ZDB-MRPHLNO-091013-4,ZFIN:ZDB-MRPHLNO-150407-1	Zfish	PMID:25520628
Biological Process	GO:0021854	hypothalamus development	nkx2.4a	IGI	ZFIN:ZDB-MRPHLNO-091013-2,ZFIN:ZDB-MRPHLNO-150407-1	Zfish	PMID:25520628
Biological Process	GO:0021854	hypothalamus development	nkx2.4a	IGI	ZFIN:ZDB-MRPHLNO-091013-2,ZFIN:ZDB-MRPHLNO-091013-4,ZFIN:ZDB-MRPHLNO-150407-1	Zfish	PMID:25520628
Biological Process	GO:0030878	thyroid gland development	nkx2.4b	IMP	ZFIN:ZDB-GENO-220519-1	Zfish	PMID:32644242
Biological Process	GO:0030878	thyroid gland development	nkx2.4b	IMP		Zfish	PMID:14568547

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern