Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nkx2-5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NKX2-5
- Mouse genes Nkx2-5
- Rat genes Nkx2-5
- Zfish genes nkx2.5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx2-5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	NKX2-5	IDA		Human	PMID:16678093
Molecular Function	GO:0003682	chromatin binding	Nkx2-5	IDA		Mouse	PMID:19483677
Molecular Function	GO:0003682	chromatin binding	Nkx2-5	IDA		Mouse	PMID:21379568
Molecular Function	GO:0003677	DNA binding	NKX2-5	IDA		Human	PMID:9858576
Molecular Function	GO:0003677	DNA binding	Nkx2-5	IDA		Mouse	MGI:MGI:3843444\|PMID:11042197
Molecular Function	GO:0003677	DNA binding	Nkx2-5	IDA		Mouse	PMID:12754203
Molecular Function	GO:0003677	DNA binding	Nkx2-5	IDA		Mouse	PMID:12297045
Molecular Function	GO:0003677	DNA binding	Nkx2-5	IDA		Mouse	PMID:15363409
Molecular Function	GO:0003677	DNA binding	Nkx2-5	IDA		Mouse	PMID:8900044
Molecular Function	GO:0001216	DNA-binding transcription activator activity	NKX2-5	IDA		Human	PMID:29325903
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NKX2-5	IMP		Human	PMID:15649947
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NKX2-5	IDA		Human	PMID:19578358
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nkx2-5	IDA		Mouse	MGI:MGI:3055632\|PMID:15363409
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nkx2-5	IDA		Mouse	MGI:MGI:4354665\|PMID:19578358
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-5	IDA		Human	PMID:9312027
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-5	IDA		Human	PMID:10948187
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-5	IDA		Human	PMID:11431700
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-5	IMP		Human	PMID:11431700
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-5	IDA		Human	PMID:9858576
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-5	IDA		Mouse	PMID:11572777
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-5	IDA		Mouse	PMID:16510504
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-5	IDA		Mouse	PMID:8900044
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-5	IDA		Rat	PMID:12775767\|RGD:1580258
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-5	IDA		Rat	PMID:12824294\|RGD:727751
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Nkx2-5	IDA		Mouse	PMID:21379568
Molecular Function	GO:0042826	histone deacetylase binding	Nkx2-5	IPI	RGD:619980	Rat	PMID:19638401\|RGD:9590153
Molecular Function	GO:0042802	identical protein binding	Nkx2-5	IPI	RGD:620520	Rat	PMID:11042197\|RGD:2306248
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:P43694	Human	PMID:10075728
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q99593	Human	PMID:11431700
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q99593-1	Human	PMID:11431700
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q99593	Human	PMID:12499378
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q71FD7	Human	PMID:14757752
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:O75925	Human	PMID:18579533
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q8IZQ8	Human	PMID:19797053
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q99593	Human	PMID:26926761
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q14511	Human	PMID:29899023
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:O15266-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q15642-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:Q93062-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:O00629	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	NKX2-5	IPI	UniProtKB:P43694	Human	PMID:9312027
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:O94983	Mouse	MGI:MGI:3692336\|PMID:16678093
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q9QZR5	Mouse	MGI:MGI:1303245\|PMID:9748262
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q08369\|UniProtKB:Q99593	Mouse	MGI:MGI:3687882\|PMID:12845333
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q08369	Mouse	MGI:MGI:3687882\|PMID:12845333
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q9ES03	Mouse	MGI:MGI:5284807\|PMID:14550786
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:P11831	Mouse	MGI:MGI:83559\|PMID:8887666
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q9EPZ6	Mouse	MGI:MGI:3722519\|PMID:17584735
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q08369	Mouse	MGI:MGI:4839464\|PMID:9584153
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q8BVE8-2	Mouse	MGI:MGI:3850584\|PMID:19483677
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	UniProtKB:Q62315	Mouse	MGI:MGI:3525051\|PMID:15542826
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	PR:P79457	Mouse	PMID:22192413
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	PR:P70326	Mouse	PMID:11572777
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	PR:Q60707	Mouse	PMID:12023302
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	PR:O88621	Mouse	PMID:15363409
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	PR:P79457	Mouse	PMID:23028370
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	PR:Q61039	Mouse	PMID:12392994
Molecular Function	GO:0005515	protein binding	Nkx2-5	IPI	RGD:620036	Rat	PMID:17544441\|RGD:2289909
Molecular Function	GO:0042803	protein homodimerization activity	Nkx2-5	IDA		Mouse	MGI:MGI:3843444\|PMID:11042197
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX2-5	IMP		Human	PMID:15649947
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX2-5	IDA		Human	PMID:22849347
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX2-5	IDA		Human	PMID:26926761
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nkx2-5	IDA		Mouse	MGI:MGI:83559\|PMID:8887666
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	NKX2-5	IPI	UniProtKB:Q99593	Human	PMID:11431700
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	NKX2-5	IPI	UniProtKB:P43694	Human	PMID:9858576
Molecular Function	GO:0043565	sequence-specific DNA binding	NKX2-5	IDA		Human	PMID:10948187
Molecular Function	GO:0043565	sequence-specific DNA binding	Nkx2-5	IDA		Rat	PMID:11042197\|RGD:2306248
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NKX2-5	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NKX2-5	IDA		Human	PMID:19479054
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NKX2-5	IDA		Human	PMID:29899023
Cellular Component	GO:0005737	cytoplasm	Nkx2-5	IDA		Mouse	MGI:MGI:3828406\|PMID:15653675
Cellular Component	GO:0005634	nucleus	NKX2-5	IDA		Human	PMID:10948187
Cellular Component	GO:0005634	nucleus	NKX2-5	IDA		Human	PMID:29899023
Cellular Component	GO:0005634	nucleus	NKX2-5	IDA		Human	PMID:9858576
Cellular Component	GO:0005634	nucleus	Nkx2-5	IDA		Mouse	MGI:MGI:5284807\|PMID:14550786
Cellular Component	GO:0005634	nucleus	Nkx2-5	IDA		Mouse	MGI:MGI:3828406\|PMID:15653675
Cellular Component	GO:0005634	nucleus	Nkx2-5	IDA		Mouse	PMID:21931855
Cellular Component	GO:0005634	nucleus	Nkx2-5	IDA		Mouse	PMID:23892084
Cellular Component	GO:0005634	nucleus	Nkx2-5	IDA		Rat	PMID:17544441\|RGD:2289909
Cellular Component	GO:0032991	protein-containing complex	NKX2-5	IDA		Human	PMID:26926761
Cellular Component	GO:0032993	protein-DNA complex	NKX2-5	IDA		Human	PMID:22849347
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NKX2-5	IDA		Human	PMID:9312027
Cellular Component	GO:0005667	transcription regulator complex	Nkx2-5	IDA		Mouse	PMID:12023302
Cellular Component	GO:0005667	transcription regulator complex	Nkx2-5	IPI	UniProtKB:Q5SSP7	Mouse	PMID:18285513
Biological Process	GO:0007512	adult heart development	NKX2-5	IMP		Human	PMID:9651244
Biological Process	GO:0007512	adult heart development	Nkx2-5	IMP	MGI:MGI:1927227	Mouse	PMID:7628699
Biological Process	GO:0006915	apoptotic process	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0003278	apoptotic process involved in heart morphogenesis	Nkx2-5	IMP		Mouse	PMID:16510504
Biological Process	GO:0060840	artery development	nkx2.5	IGI	ZFIN:ZDB-GENE-051113-88	Zfish	PMID:26255850
Biological Process	GO:0003228	atrial cardiac muscle tissue development	Nkx2-5	IMP		Mouse	MGI:MGI:3783941\|PMID:17234970
Biological Process	GO:0060413	atrial septum morphogenesis	NKX2-5	IMP		Human	PMID:10587520
Biological Process	GO:0060413	atrial septum morphogenesis	NKX2-5	IMP		Human	PMID:9651244
Biological Process	GO:0060928	atrioventricular node cell development	Nkx2-5	IMP	MGI:MGI:3042511	Mouse	PMID:19546853
Biological Process	GO:0060929	atrioventricular node cell fate commitment	Nkx2-5	IMP	MGI:MGI:3042511	Mouse	PMID:15109497
Biological Process	GO:0003162	atrioventricular node development	Nkx2-5	IMP		Mouse	MGI:MGI:3829107\|PMID:18689573
Biological Process	GO:0003166	bundle of His development	Nkx2-5	IGI	MGI:MGI:102541	Mouse	PMID:17604724
Biological Process	GO:0003205	cardiac chamber development	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1,ZFIN:ZDB-GENO-181015-6	Zfish	PMID:29361575
Biological Process	GO:0003205	cardiac chamber development	nkx2.5	IMP	ZFIN:ZDB-GENO-131223-4	Zfish	PMID:25536398
Biological Process	GO:0003205	cardiac chamber development	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1	Zfish	PMID:25536398
Biological Process	GO:0003161	cardiac conduction system development	NKX2-5	IMP		Human	PMID:15109497
Biological Process	GO:0003161	cardiac conduction system development	NKX2-5	IMP		Human	PMID:27207958
Biological Process	GO:0003161	cardiac conduction system development	Nkx2-5	IGI	MGI:MGI:106211	Mouse	PMID:21690310
Biological Process	GO:0055013	cardiac muscle cell development	Nkx2-5	IMP		Mouse	MGI:MGI:3836832\|PMID:19166829
Biological Process	GO:0055013	cardiac muscle cell development	Nkx2-5	IMP		Mouse	MGI:MGI:5285465\|PMID:21640717
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nkx2-5	IDA		Mouse	MGI:MGI:5142394\|PMID:9857019
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nkx2-5	IGI	MGI:MGI:99458	Mouse	PMID:19035347
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nkx2-5	IMP	MGI:MGI:1857618	Mouse	PMID:10021345
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nkx2-5	IMP	MGI:MGI:3655239	Mouse	PMID:17234970
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nkx2-5	IEP		Rat	PMID:20486789\|RGD:5131636
Biological Process	GO:0055007	cardiac muscle cell differentiation	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0055007	cardiac muscle cell differentiation	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1,ZFIN:ZDB-GENO-181015-6	Zfish	PMID:29361575
Biological Process	GO:0060038	cardiac muscle cell proliferation	Nkx2-5	IGI	MGI:MGI:109452	Mouse	PMID:17350578
Biological Process	GO:0060038	cardiac muscle cell proliferation	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0060038	cardiac muscle cell proliferation	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:18718462
Biological Process	GO:0060048	cardiac muscle contraction	Nkx2-5	IMP	MGI:MGI:3042511	Mouse	PMID:19546853
Biological Process	GO:0048738	cardiac muscle tissue development	Nkx2-5	IMP	MGI:MGI:1927227	Mouse	PMID:7628699
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	NKX2-5	IMP		Human	PMID:11889119
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	Nkx2-5	IMP		Mouse	MGI:MGI:5285465\|PMID:21640717
Biological Process	GO:0003231	cardiac ventricle development	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1	Zfish	PMID:25536398
Biological Process	GO:0003211	cardiac ventricle formation	Nkx2-5	IGI	MGI:MGI:99458	Mouse	PMID:19035347
Biological Process	GO:0003208	cardiac ventricle morphogenesis	Nkx2-5	IMP		Mouse	PMID:16510504
Biological Process	GO:0008283	cell population proliferation	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0071363	cellular response to growth factor stimulus	Nkx2-5	IEP		Rat	PMID:19395679\|RGD:5131637
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Nkx2-5	IEP		Rat	PMID:23744058\|RGD:12911227
Biological Process	GO:0035050	embryonic heart tube development	Nkx2-5	IGI	MGI:MGI:1888496	Mouse	PMID:15843414
Biological Process	GO:0035050	embryonic heart tube development	nkx2.5	IMP	ZFIN:ZDB-MRPHLNO-090826-10	Zfish	PMID:18718462
Biological Process	GO:0035050	embryonic heart tube development	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-12,ZFIN:ZDB-MRPHLNO-090826-15	Zfish	PMID:18718462
Biological Process	GO:0035050	embryonic heart tube development	nkx2.5	IMP	ZFIN:ZDB-MRPHLNO-090826-12	Zfish	PMID:18718462
Biological Process	GO:0035050	embryonic heart tube development	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:18718462
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	Nkx2-5	IMP	MGI:MGI:1927227	Mouse	PMID:9192865
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nkx2.5	IMP	ZFIN:ZDB-MRPHLNO-090826-10	Zfish	PMID:28109039
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1	Zfish	PMID:28109039
Biological Process	GO:1904019	epithelial cell apoptotic process	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0030855	epithelial cell differentiation	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0050673	epithelial cell proliferation	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0060047	heart contraction	Nkx2-5	IGI	MGI:MGI:106211	Mouse	PMID:21690310
Biological Process	GO:0060047	heart contraction	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1	Zfish	PMID:28615160
Biological Process	GO:0007507	heart development	Nkx2-5	IMP	MGI:MGI:1857618	Mouse	PMID:15085192
Biological Process	GO:0007507	heart development	Nkx2-5	IMP	MGI:MGI:1857618	Mouse	PMID:10021345
Biological Process	GO:0007507	heart development	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0007507	heart development	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1	Zfish	PMID:25536398
Biological Process	GO:0007507	heart development	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1,ZFIN:ZDB-GENO-181015-6	Zfish	PMID:29361575
Biological Process	GO:0007507	heart development	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-050527-2,ZFIN:ZDB-MRPHLNO-060407-3	Zfish	PMID:21750034
Biological Process	GO:0001947	heart looping	Nkx2-5	IMP		Mouse	PMID:16510504
Biological Process	GO:0001947	heart looping	Nkx2-5	IMP	MGI:MGI:1927227	Mouse	PMID:9192865
Biological Process	GO:0001947	heart looping	Nkx2-5	IMP	MGI:MGI:1927227	Mouse	PMID:7628699
Biological Process	GO:0001947	heart looping	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0003007	heart morphogenesis	Nkx2-5	IMP		Mouse	MGI:MGI:3783941\|PMID:17234970
Biological Process	GO:0003007	heart morphogenesis	Nkx2-5	IMP	MGI:MGI:1927227	Mouse	PMID:11784028
Biological Process	GO:0003007	heart morphogenesis	nkx2.5	IMP	ZFIN:ZDB-MRPHLNO-090826-10	Zfish	PMID:19158954
Biological Process	GO:0003007	heart morphogenesis	nkx2.5	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0060347	heart trabecula formation	Nkx2-5	IMP		Mouse	PMID:16510504
Biological Process	GO:0030097	hemopoiesis	Nkx2-5	IMP	MGI:MGI:1857618	Mouse	PMID:10021345
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Nkx2-5	IDA		Mouse	MGI:MGI:3848291\|PMID:19479054
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	NKX2-5	IMP		Human	PMID:11889119
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Nkx2-5	IMP		Mouse	MGI:MGI:3784761\|PMID:11889119
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0010832	negative regulation of myotube differentiation	NKX2-5	IMP		Human	PMID:15653675
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NKX2-5	IMP		Human	PMID:19479054
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:1276574	Mouse	PMID:19483677
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Mouse	PMID:12023302
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Rat	PMID:19395679\|RGD:5131637
Biological Process	GO:0003151	outflow tract morphogenesis	Nkx2-5	IMP		Mouse	PMID:16510504
Biological Process	GO:0003151	outflow tract morphogenesis	Nkx2-5	IGI	MGI:MGI:99458	Mouse	PMID:19035347
Biological Process	GO:0003148	outflow tract septum morphogenesis	NKX2-5	IMP		Human	PMID:20807224
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	nkx2.5	IMP	ZFIN:ZDB-MRPHLNO-090826-12	Zfish	PMID:24161929
Biological Process	GO:0060037	pharyngeal system development	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0051891	positive regulation of cardioblast differentiation	Nkx2-5	IMP		Mouse	MGI:MGI:3784761\|PMID:11889119
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NKX2-5	IDA		Human	PMID:11431700
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nkx2-5	IDA		Mouse	PMID:14978031
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nkx2-5	IDA		Mouse	PMID:11572777
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Nkx2-5	IGI	MGI:MGI:97351	Mouse	PMID:11390666
Biological Process	GO:0010628	positive regulation of gene expression	Nkx2-5	IDA		Mouse	MGI:MGI:5142394\|PMID:9857019
Biological Process	GO:0045823	positive regulation of heart contraction	Nkx2-5	IMP		Mouse	MGI:MGI:3829107\|PMID:18689573
Biological Process	GO:0045666	positive regulation of neuron differentiation	NKX2-5	IMP		Human	PMID:15653675
Biological Process	GO:0010765	positive regulation of sodium ion transport	Nkx2-5	IMP		Mouse	MGI:MGI:3829107\|PMID:18689573
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IGI	UniProtKB:O94983	Human	PMID:16678093
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IDA		Human	PMID:10948187
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IMP		Human	PMID:11431700
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IMP		Human	PMID:15649947
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IMP		Human	PMID:18079734
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IMP		Human	PMID:19479054
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IDA		Human	PMID:19578358
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IDA		Human	PMID:29325903
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-5	IMP		Human	PMID:29899023
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IMP		Mouse	MGI:MGI:3829107\|PMID:18689573
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Mouse	MGI:MGI:4354665\|PMID:19578358
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:103580	Mouse	PMID:12392994
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Mouse	PMID:8900044
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:98493	Mouse	PMID:16556915
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:1197010	Mouse	PMID:21931855
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Mouse	PMID:16510504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Mouse	PMID:16380715
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:102541	Mouse	PMID:17604724
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:1347465	Mouse	PMID:15363409
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	Nkx2-5	IDA		Mouse	MGI:MGI:83559\|PMID:8887666
Biological Process	GO:0003342	proepicardium development	Nkx2-5	IMP	MGI:MGI:2654594	Mouse	PMID:18722343
Biological Process	GO:0003350	pulmonary myocardium development	Nkx2-5	IMP	MGI:MGI:2448972	Mouse	PMID:17823370
Biological Process	GO:0003168	Purkinje myocyte differentiation	Nkx2-5	IMP	MGI:MGI:1857618	Mouse	PMID:17250822
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.5	IMP	ZFIN:ZDB-GENO-131212-1	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.5	IGI	ZFIN:ZDB-GENE-990415-179	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.5	IGI	ZFIN:ZDB-GENO-131212-1,ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.5	IGI	ZFIN:ZDB-GENO-131223-4	Zfish	PMID:24026123
Biological Process	GO:1903779	regulation of cardiac conduction	Nkx2-5	IMP		Mouse	MGI:MGI:3829107\|PMID:18689573
Biological Process	GO:0060043	regulation of cardiac muscle cell proliferation	Nkx2-5	IDA		Mouse	PMID:20713518
Biological Process	GO:0055117	regulation of cardiac muscle contraction	Nkx2-5	IMP		Mouse	MGI:MGI:3829107\|PMID:18689573
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nkx2-5	IDA		Mouse	PMID:14645532
Biological Process	GO:0032355	response to estradiol	Nkx2-5	IEP		Rat	PMID:18832095\|RGD:2306247
Biological Process	GO:0003221	right ventricular cardiac muscle tissue morphogenesis	NKX2-5	IMP		Human	PMID:20807224
Biological Process	GO:0003285	septum secundum development	NKX2-5	IMP		Human	PMID:10587520
Biological Process	GO:0048536	spleen development	NKX2-5	IMP		Human	PMID:22560297
Biological Process	GO:0048536	spleen development	Nkx2-5	IGI	MGI:MGI:104737	Mouse	PMID:22560297
Biological Process	GO:0048536	spleen development	Nkx2-5	IGI	MGI:MGI:97495	Mouse	PMID:22560297
Biological Process	GO:0030878	thyroid gland development	NKX2-5	IMP		Human	PMID:16418214
Biological Process	GO:0030878	thyroid gland development	Nkx2-5	IMP		Mouse	MGI:MGI:3828401\|PMID:16418214
Biological Process	GO:0006366	transcription by RNA polymerase II	Nkx2-5	IGI	MGI:MGI:102541	Mouse	PMID:17604724
Biological Process	GO:0001570	vasculogenesis	Nkx2-5	IMP	MGI:MGI:1857618	Mouse	PMID:10021345
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	Nkx2-5	IMP	MGI:MGI:3042511	Mouse	PMID:19546853
Biological Process	GO:0060412	ventricular septum morphogenesis	NKX2-5	IMP		Human	PMID:10587520
Biological Process	GO:0060412	ventricular septum morphogenesis	NKX2-5	IMP		Human	PMID:20807224
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	Nkx2-5	IMP	MGI:MGI:3042511	Mouse	PMID:15109497

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/02/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.