Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX2-6
  • Mouse genes Nkx2-6
  • Rat genes Nkx2-6
  • Zfish genes nkx2.7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx2-6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NKX2-6	IMP		Human	PMID:15649947
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-6	IDA		Human	PMID:15649947
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX2-6	IMP		Human	PMID:15649947
Biological Process	GO:0006915	apoptotic process	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0055014	atrial cardiac muscle cell development	Nkx2-6	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:0055007	cardiac muscle cell differentiation	nkx2.7	IMP	ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0055007	cardiac muscle cell differentiation	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0060038	cardiac muscle cell proliferation	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:18718462
Biological Process	GO:0060038	cardiac muscle cell proliferation	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0008283	cell population proliferation	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0048565	digestive tract development	Nkx2-6	IEP		Mouse	MGI:MGI:3828420|PMID:9545560
Biological Process	GO:0035050	embryonic heart tube development	NKX2-6	IMP		Human	PMID:15649947
Biological Process	GO:0035050	embryonic heart tube development	Nkx2-6	IEP		Mouse	MGI:MGI:3828420|PMID:9545560
Biological Process	GO:0035050	embryonic heart tube development	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-12,ZFIN:ZDB-MRPHLNO-090826-15	Zfish	PMID:18718462
Biological Process	GO:0035050	embryonic heart tube development	nkx2.7	IMP	ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:18718462
Biological Process	GO:0035050	embryonic heart tube development	nkx2.7	IMP	ZFIN:ZDB-MRPHLNO-090826-15	Zfish	PMID:18718462
Biological Process	GO:0035050	embryonic heart tube development	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:18718462
Biological Process	GO:1904019	epithelial cell apoptotic process	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0030855	epithelial cell differentiation	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0050673	epithelial cell proliferation	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0007507	heart development	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0001947	heart looping	nkx2.7	IMP	ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0001947	heart looping	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0003007	heart morphogenesis	nkx2.7	IMP	ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0003007	heart morphogenesis	nkx2.7	IGI	ZFIN:ZDB-MRPHLNO-090826-10,ZFIN:ZDB-MRPHLNO-090916-1	Zfish	PMID:19158954
Biological Process	GO:0021854	hypothalamus development	Nkx2-6	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0060039	pericardium development	Nkx2-6	IEP		Mouse	MGI:MGI:3828420|PMID:9545560
Biological Process	GO:0060037	pharyngeal system development	Nkx2-6	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:0060037	pharyngeal system development	Nkx2-6	IEP		Mouse	MGI:MGI:3828420|PMID:9545560
Biological Process	GO:0060037	pharyngeal system development	Nkx2-6	IEP		Mouse	MGI:MGI:1195840|PMID:9486544
Biological Process	GO:0060037	pharyngeal system development	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Nkx2-6	IGI	MGI:MGI:97350	Mouse	PMID:11390666
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-6	IMP		Human	PMID:15649947
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.7	IGI	ZFIN:ZDB-GENE-980526-321	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.7	IGI	ZFIN:ZDB-GENO-131212-1,ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.7	IMP	ZFIN:ZDB-MRPHLNO-090826-13	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.7	IMP	ZFIN:ZDB-GENO-131218-1	Zfish	PMID:24026123
Biological Process	GO:1901210	regulation of cardiac chamber formation	nkx2.7	IGI	ZFIN:ZDB-GENO-131223-4	Zfish	PMID:24026123
Biological Process	GO:0043586	tongue development	Nkx2-6	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:0055015	ventricular cardiac muscle cell development	Nkx2-6	IEP		Mouse	MGI:MGI:1267297|PMID:9621431

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern