Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX2-8
  • Mouse genes Nkx2-9
  • Rat genes Nkx2-8
  • Zfish genes nkx2.2b,nkx2.9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx2-9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NKX2-8	IDA		Human	PMID:12167706
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX2-8	IDA		Human	PMID:9446603
Molecular Function	GO:0003690	double-stranded DNA binding	NKX2-8	IDA		Human	PMID:9446603
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX2-8	IDA		Human	PMID:12167706
Molecular Function	GO:0043565	sequence-specific DNA binding	NKX2-8	IDA		Human	PMID:12167706
Molecular Function	GO:0043565	sequence-specific DNA binding	Nkx2-8	IDA		Rat	PMID:12167706|RGD:1302328
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NKX2-8	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Nkx2-8	IDA		Rat	PMID:12167706|RGD:1302328
Biological Process	GO:0007409	axonogenesis	Nkx2-9	IMP	MGI:MGI:2655862	Mouse	PMID:16267219
Biological Process	GO:0006351	DNA-templated transcription	NKX2-8	IDA		Human	PMID:9446603
Biological Process	GO:0050673	epithelial cell proliferation	Nkx2-9	IMP	MGI:MGI:3692933	Mouse	PMID:17079460
Biological Process	GO:0021508	floor plate formation	nkx2.2b	IMP	ZFIN:ZDB-MRPHLNO-070305-2	Zfish	PMID:17045256
Biological Process	GO:0030324	lung development	Nkx2-9	IMP	MGI:MGI:3692933	Mouse	PMID:17079460
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Nkx2-9	IMP	MGI:MGI:3692933	Mouse	PMID:17079460
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX2-8	IDA		Human	PMID:12167706
Biological Process	GO:0030323	respiratory tube development	Nkx2-9	IMP	MGI:MGI:3692933	Mouse	PMID:17079460
Biological Process	GO:0006366	transcription by RNA polymerase II	NKX2-8	IDA		Human	PMID:9446603
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.9	IGI	ZFIN:ZDB-MRPHLNO-080321-2,ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.9	IMP	ZFIN:ZDB-MRPHLNO-100811-3	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.9	IGI	ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.9	IGI	ZFIN:ZDB-MRPHLNO-080321-2,ZFIN:ZDB-MRPHLNO-100811-3	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.2b	IGI	ZFIN:ZDB-MRPHLNO-080321-2,ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.2b	IGI	ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern