Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX3-1
  • Mouse genes Nkx3-1
  • Rat genes Nkx3-1
  • Zfish genes nkx3-1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx3-1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	NKX3-1	IDA		Human	PMID:19266349
Molecular Function	GO:0003677	DNA binding	Nkx3-1	IDA		Mouse	PMID:10993896
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NKX3-1	IDA		Human	PMID:20855495
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx3-1	IMP		Mouse	MGI:MGI:5294290|PMID:18296735
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx3-1	IDA		Mouse	PMID:10993896
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NKX3-1	IDA		Human	PMID:18794125
Molecular Function	GO:0140297	DNA-binding transcription factor binding	NKX3-1	IPI	UniProtKB:P11831	Human	PMID:18296735
Molecular Function	GO:0140297	DNA-binding transcription factor binding	NKX3-1	IPI	UniProtKB:P08047	Human	PMID:20716579
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Nkx3-1	IPI	UniProtKB:P11831	Mouse	MGI:MGI:5294290|PMID:18296735
Molecular Function	GO:0042826	histone deacetylase binding	NKX3-1	IPI	UniProtKB:Q13547	Human	PMID:18974119
Molecular Function	GO:0097162	MADS box domain binding	Nkx3-1	IDA		Mouse	MGI:MGI:5294290|PMID:18296735
Molecular Function	GO:0030331	nuclear estrogen receptor binding	NKX3-1	IDA		Human	PMID:18794125
Molecular Function	GO:0004879	nuclear receptor activity	NKX3-1	IDA		Human	PMID:19886863
Molecular Function	GO:0003676	nucleic acid binding	NKX3-1	EXP		Human	PMID:19780584
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:P11387	Human	PMID:17234752
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:Q9NS56	Human	PMID:18077445
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:Q8IZQ8	Human	PMID:19797053
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:Q6Q8B3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:Q8TAU3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:Q96BI1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NKX3-1	IPI	UniProtKB:Q9BQY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nkx3-1	IPI	PR:Q9Z2G0	Mouse	PMID:18816836
Molecular Function	GO:0043621	protein self-association	NKX3-1	IDA		Human	PMID:19780584
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NKX3-1	IDA		Human	PMID:18974119
Molecular Function	GO:0043565	sequence-specific DNA binding	NKX3-1	IDA		Human	PMID:19780584
Molecular Function	GO:0043565	sequence-specific DNA binding	Nkx3-1	IDA		Mouse	MGI:MGI:87385|PMID:9142502
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NKX3-1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NKX3-1	IDA		Human	PMID:19263243
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NKX3-1	IDA		Human	PMID:20855495
Molecular Function	GO:0008134	transcription factor binding	Nkx3-1	IDA		Mouse	PMID:10993896
Molecular Function	GO:0140416	transcription regulator inhibitor activity	NKX3-1	IDA		Human	PMID:18794125
Cellular Component	GO:0005829	cytosol	NKX3-1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NKX3-1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NKX3-1	IDA		Human	PMID:18757402
Cellular Component	GO:0005634	nucleus	NKX3-1	IDA		Human	PMID:19263243
Cellular Component	GO:0005634	nucleus	Nkx3-1	IDA		Mouse	PMID:15987773
Cellular Component	GO:0090734	site of DNA damage	NKX3-1	IDA		Human	PMID:20395202
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	NKX3-1	IDA		Human	PMID:17486276
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	NKX3-1	IDA		Human	PMID:19266349
Biological Process	GO:0030521	androgen receptor signaling pathway	NKX3-1	IDA		Human	PMID:19886863
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	Nkx3-1	IMP	MGI:MGI:1926960	Mouse	PMID:10215624
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	Nkx3-1	IMP	MGI:MGI:1928655	Mouse	PMID:11002344
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	Nkx3-1	IMP	MGI:MGI:1928654	Mouse	PMID:10906459
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Nkx3-1	IMP	MGI:MGI:1928655	Mouse	PMID:11002344
Biological Process	GO:0071456	cellular response to hypoxia	NKX3-1	IDA		Human	PMID:21056661
Biological Process	GO:0071347	cellular response to interleukin-1	NKX3-1	IEP		Human	PMID:18757402
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	NKX3-1	IDA		Human	PMID:19886863
Biological Process	GO:0071356	cellular response to tumor necrosis factor	NKX3-1	IEP		Human	PMID:18757402
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	NKX3-1	IEP		Human	PMID:18757402
Biological Process	GO:0006974	DNA damage response	NKX3-1	IDA		Human	PMID:20395202
Biological Process	GO:0035907	dorsal aorta development	Nkx3-1	IEP		Mouse	MGI:MGI:87385|PMID:9142502
Biological Process	GO:0050673	epithelial cell proliferation	Nkx3-1	IMP	MGI:MGI:1928655	Mouse	PMID:11002344
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	Nkx3-1	IMP	MGI:MGI:3045877	Mouse	PMID:11839815
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	Nkx3-1	IMP	MGI:MGI:1928655	Mouse	PMID:11002344
Biological Process	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	Nkx3-1	IMP	MGI:MGI:1928654	Mouse	PMID:10906459
Biological Process	GO:0007507	heart development	Nkx3-1	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:0008584	male gonad development	Nkx3-1	IEP		Mouse	MGI:MGI:87385|PMID:9142502
Biological Process	GO:0001656	metanephros development	Nkx3-1	IEP		Mouse	MGI:MGI:87385|PMID:9142502
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	NKX3-1	IGI	UniProtKB:P46527	Human	PMID:19266349
Biological Process	GO:0008285	negative regulation of cell population proliferation	NKX3-1	IDA		Human	PMID:17486276
Biological Process	GO:0008285	negative regulation of cell population proliferation	NKX3-1	IDA		Human	PMID:19266349
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nkx3-1	IGI	UniProtKB:P17936	Mouse	PMID:19258508
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NKX3-1	IMP		Human	PMID:18360715
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NKX3-1	IDA		Human	PMID:18794125
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NKX3-1	IMP		Human	PMID:18974119
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NKX3-1	IDA		Human	PMID:19597465
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nkx3-1	IMP		Mouse	MGI:MGI:4366606|PMID:19597465
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Nkx3-1	IMP	MGI:MGI:1928655	Mouse	PMID:11002344
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	Nkx3-1	IMP	MGI:MGI:1928655	Mouse	PMID:11002344
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	Nkx3-1	IMP	MGI:MGI:3045877	Mouse	PMID:11839815
Biological Process	GO:0010629	negative regulation of gene expression	NKX3-1	IDA		Human	PMID:17486276
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	Nkx3-1	IDA		Mouse	PMID:19258508
Biological Process	GO:0060037	pharyngeal system development	Nkx3-1	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:2000836	positive regulation of androgen secretion	NKX3-1	IDA		Human	PMID:19886863
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	NKX3-1	IDA		Human	PMID:20599703
Biological Process	GO:0010942	positive regulation of cell death	NKX3-1	IDA		Human	PMID:19266349
Biological Process	GO:0051781	positive regulation of cell division	NKX3-1	IMP		Human	PMID:20855495
Biological Process	GO:0008284	positive regulation of cell population proliferation	NKX3-1	IMP		Human	PMID:18360715
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	NKX3-1	IDA		Human	PMID:20599703
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Nkx3-1	IMP		Mouse	MGI:MGI:5294290|PMID:18296735
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NKX3-1	IMP		Human	PMID:18360715
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nkx3-1	IDA		Mouse	PMID:10993896
Biological Process	GO:0010628	positive regulation of gene expression	NKX3-1	IDA		Human	PMID:17486276
Biological Process	GO:0010628	positive regulation of gene expression	NKX3-1	IDA		Human	PMID:20599703
Biological Process	GO:0010628	positive regulation of gene expression	NKX3-1	IMP		Human	PMID:20716579
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	NKX3-1	IDA		Human	PMID:17486276
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	NKX3-1	IMP		Human	PMID:20855495
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	NKX3-1	IDA		Human	PMID:20395202
Biological Process	GO:0001934	positive regulation of protein phosphorylation	NKX3-1	IDA		Human	PMID:20395202
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX3-1	IDA		Human	PMID:19797053
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NKX3-1	IDA		Human	PMID:20855495
Biological Process	GO:0030850	prostate gland development	Nkx3-1	IEP		Mouse	MGI:MGI:87385|PMID:9142502
Biological Process	GO:0043491	protein kinase B signaling	NKX3-1	IMP		Human	PMID:19597465
Biological Process	GO:0043491	protein kinase B signaling	Nkx3-1	IMP		Mouse	MGI:MGI:4366606|PMID:19597465
Biological Process	GO:0032880	regulation of protein localization	NKX3-1	IMP		Human	PMID:20395202
Biological Process	GO:0033574	response to testosterone	Nkx3-1	IMP		Mouse	MGI:MGI:87385|PMID:9142502
Biological Process	GO:0007431	salivary gland development	Nkx3-1	IMP	MGI:MGI:1928654	Mouse	PMID:10906459
Biological Process	GO:0001756	somitogenesis	Nkx3-1	IEP		Mouse	MGI:MGI:1267297|PMID:9621431
Biological Process	GO:0001655	urogenital system development	Nkx3-1	IEP		Mouse	MGI:MGI:87385|PMID:9142502

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern