Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX3-2
  • Mouse genes Nkx3-2
  • Rat genes Nkx3-2
  • Zfish genes nkx3-2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx3-2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nkx3-2	IDA		Mouse	MGI:MGI:5572881|PMID:15703179
Molecular Function	GO:0005515	protein binding	NKX3-2	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nkx3-2	IDA		Mouse	MGI:MGI:5572881|PMID:15703179
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NKX3-2	IDA		Human	PMID:28473536
Biological Process	GO:0048513	animal organ development	Nkx3-2	IMP	MGI:MGI:3848005	Mouse	PMID:19208343
Biological Process	GO:0048645	animal organ formation	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:10449756
Biological Process	GO:0007368	determination of left/right symmetry	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:15329346
Biological Process	GO:0055123	digestive system development	Nkx3-2	IMP	MGI:MGI:3848005	Mouse	PMID:19208343
Biological Process	GO:0048706	embryonic skeletal system development	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:10449756
Biological Process	GO:0048706	embryonic skeletal system development	Nkx3-2	IMP	MGI:MGI:1857926	Mouse	PMID:10572046
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nkx3-2	IMP	ZFIN:ZDB-MRPHLNO-051221-6	Zfish	PMID:15128673
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nkx3-2	IGI	ZFIN:ZDB-GENO-090624-3,ZFIN:ZDB-MRPHLNO-051221-6	Zfish	PMID:15128673
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nkx3-2	IMP	ZFIN:ZDB-MRPHLNO-051221-6	Zfish	PMID:12588851
Biological Process	GO:0060576	intestinal epithelial cell development	Nkx3-2	IGI	MGI:MGI:2177178	Mouse	PMID:21307095
Biological Process	GO:0042474	middle ear morphogenesis	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:14973294
Biological Process	GO:0043066	negative regulation of apoptotic process	Nkx3-2	IMP	MGI:MGI:1857926	Mouse	PMID:10572046
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Nkx3-2	IMP		Mouse	MGI:MGI:3617032|PMID:16421188
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nkx3-2	IDA		Mouse	MGI:MGI:5572881|PMID:15703179
Biological Process	GO:0031016	pancreas development	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:15329346
Biological Process	GO:0001501	skeletal system development	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:11523821
Biological Process	GO:0048705	skeletal system morphogenesis	Nkx3-2	IMP	MGI:MGI:1857926	Mouse	PMID:10572046
Biological Process	GO:0048536	spleen development	Nkx3-2	IMP	MGI:MGI:3848005	Mouse	PMID:19208343
Biological Process	GO:0048536	spleen development	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:10449756
Biological Process	GO:0048536	spleen development	Nkx3-2	IMP	MGI:MGI:1857926	Mouse	PMID:10572046
Biological Process	GO:0048536	spleen development	Nkx3-2	IMP	MGI:MGI:1931319	Mouse	PMID:15329346

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern