Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX6-1
  • Mouse genes Nkx6-1
  • Rat genes Nkx6-1
  • Zfish genes nkx6.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx6-1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nkx6-1	IDA		Rat	PMID:15883383|RGD:2306242
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx6-1	IDA		Rat	PMID:10567713|RGD:68818
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nkx6-1	IDA		Rat	PMID:15883383|RGD:2306242
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nkx6-1	IDA		Rat	PMID:15883383|RGD:2306242
Molecular Function	GO:0043565	sequence-specific DNA binding	Nkx6-1	IDA		Rat	PMID:15883383|RGD:2306242
Cellular Component	GO:0070062	extracellular exosome	NKX6-1	HDA		Human	PMID:19056867
Cellular Component	GO:0005634	nucleus	Nkx6-1	IDA		Mouse	PMID:16306355
Cellular Component	GO:0005634	nucleus	Nkx6-1	IDA		Mouse	PMID:18076286
Cellular Component	GO:0005634	nucleus	Nkx6-1	IDA		Mouse	PMID:17928203
Cellular Component	GO:0005634	nucleus	Nkx6-1	IDA		Mouse	PMID:14573534
Cellular Component	GO:0005634	nucleus	Nkx6-1	IDA		Rat	PMID:17192469|RGD:2311229
Biological Process	GO:0045165	cell fate commitment	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-050201-3	Zfish	PMID:15456722
Biological Process	GO:0008283	cell population proliferation	Nkx6-1	IMP		Rat	PMID:18347054|RGD:2326022
Biological Process	GO:0071345	cellular response to cytokine stimulus	Nkx6-1	IEP		Rat	PMID:16948396|RGD:2298711
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Nkx6-1	IEP		Rat	PMID:20304194|RGD:2326021
Biological Process	GO:0021953	central nervous system neuron differentiation	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:19592574
Biological Process	GO:0031018	endocrine pancreas development	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:15944193
Biological Process	GO:0031018	endocrine pancreas development	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:15944193
Biological Process	GO:0031018	endocrine pancreas development	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-100609-7	Zfish	PMID:20122912
Biological Process	GO:0031018	endocrine pancreas development	nkx6.1	IGI	ZFIN:ZDB-MRPHLNO-100609-7,ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:15629702
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nkx6-1	IDA		Rat	PMID:15883383|RGD:2306242
Biological Process	GO:0022008	neurogenesis	Nkx6-1	IMP		Rat	PMID:18687784|RGD:2311166
Biological Process	GO:0030182	neuron differentiation	Nkx6-1	IDA		Mouse	PMID:10830170
Biological Process	GO:0048709	oligodendrocyte differentiation	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:15629701
Biological Process	GO:0048709	oligodendrocyte differentiation	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:15629702
Biological Process	GO:0003310	pancreatic A cell differentiation	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:15944193
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-100609-7	Zfish	PMID:20122912
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.1	IGI	ZFIN:ZDB-MRPHLNO-100609-7,ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-050201-3	Zfish	PMID:20122912
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-100609-7	Zfish	PMID:20122912
Biological Process	GO:0032024	positive regulation of insulin secretion	Nkx6-1	IMP		Rat	PMID:15883383|RGD:2306242
Biological Process	GO:0045666	positive regulation of neuron differentiation	Nkx6-1	IDA		Mouse	PMID:10830170
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:15629702
Biological Process	GO:0030516	regulation of axon extension	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:19592574
Biological Process	GO:2001222	regulation of neuron migration	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:19592574
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:20081190
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:11567614
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nkx6-1	IGI	MGI:MGI:1352738	Mouse	PMID:11567614
Biological Process	GO:0035094	response to nicotine	Nkx6-1	IEP		Rat	PMID:18687784|RGD:2311166
Biological Process	GO:0009410	response to xenobiotic stimulus	Nkx6-1	IEP		Rat	PMID:17192469|RGD:2311229
Biological Process	GO:0009410	response to xenobiotic stimulus	Nkx6-1	IEP		Rat	PMID:17229937|RGD:2326024
Biological Process	GO:0007224	smoothened signaling pathway	Nkx6-1	IDA		Mouse	PMID:18590716
Biological Process	GO:0021522	spinal cord motor neuron differentiation	nkx6.1	IGI	ZFIN:ZDB-GENE-980526-112,ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-070810-3	Zfish	PMID:17376808
Biological Process	GO:0021522	spinal cord motor neuron differentiation	nkx6.1	IGI	ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-070810-3	Zfish	PMID:17376808
Biological Process	GO:0021522	spinal cord motor neuron differentiation	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-050201-3	Zfish	PMID:17376808
Biological Process	GO:0006366	transcription by RNA polymerase II	Nkx6-1	IMP		Rat	PMID:15883383|RGD:2306242
Biological Process	GO:0003323	type B pancreatic cell development	Nkx6-1	IEP		Rat	PMID:9603781|RGD:2326025
Biological Process	GO:0003309	type B pancreatic cell differentiation	Nkx6-1	IMP	MGI:MGI:2386119	Mouse	PMID:15944193
Biological Process	GO:0003309	type B pancreatic cell differentiation	nkx6.1	IMP	ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-100609-7	Zfish	PMID:20122912
Biological Process	GO:0003309	type B pancreatic cell differentiation	nkx6.1	IGI	ZFIN:ZDB-MRPHLNO-100609-7,ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0044342	type B pancreatic cell proliferation	Nkx6-1	IDA		Rat	PMID:24706823|RGD:10054075

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern