Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX6-2
  • Mouse genes Nkx6-2
  • Rat genes Nkx6-2
  • Zfish genes nkx6.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx6-2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Nkx6-2	IDA		Mouse	MGI:MGI:6095455|PMID:9254678
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx6-2	IDA		Mouse	PMID:8096811
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nkx6-2	IDA		Mouse	MGI:MGI:52878|PMID:8096811
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nkx6-2	IDA		Mouse	MGI:MGI:52878|PMID:8096811
Molecular Function	GO:0043565	sequence-specific DNA binding	Nkx6-2	IDA		Mouse	PMID:8096811
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NKX6-2	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Nkx6-2	IDA		Mouse	MGI:MGI:3521547|PMID:15601927
Cellular Component	GO:0005634	nucleus	Nkx6-2	IDA		Mouse	PMID:11567614
Biological Process	GO:0045165	cell fate commitment	Nkx6-2	IMP	MGI:MGI:2651850	Mouse	PMID:11567614
Biological Process	GO:0022010	central nervous system myelination	Nkx6-2	IMP	MGI:MGI:3522433	Mouse	PMID:15601927
Biological Process	GO:0031018	endocrine pancreas development	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:15944193
Biological Process	GO:0031018	endocrine pancreas development	nkx6.2	IGI	ZFIN:ZDB-MRPHLNO-100609-7,ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0031018	endocrine pancreas development	nkx6.2	IMP	ZFIN:ZDB-MRPHLNO-100610-1,ZFIN:ZDB-MRPHLNO-100610-2	Zfish	PMID:20122912
Biological Process	GO:0010454	negative regulation of cell fate commitment	Nkx6-2	IMP	MGI:MGI:2651850	Mouse	PMID:11567614
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nkx6-2	IDA		Mouse	MGI:MGI:6103155|PMID:10931524
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:15629702
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nkx6-2	IDA		Mouse	PMID:8096811
Biological Process	GO:0050885	neuromuscular process controlling balance	Nkx6-2	IMP	MGI:MGI:3522433	Mouse	PMID:15601927
Biological Process	GO:0048663	neuron fate commitment	Nkx6-2	IMP	MGI:MGI:2651850	Mouse	PMID:11567614
Biological Process	GO:0048709	oligodendrocyte differentiation	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:15629702
Biological Process	GO:0048709	oligodendrocyte differentiation	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:15629701
Biological Process	GO:0003310	pancreatic A cell differentiation	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:15944193
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.2	IMP	ZFIN:ZDB-MRPHLNO-100610-2	Zfish	PMID:20122912
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.2	IGI	ZFIN:ZDB-MRPHLNO-100609-7,ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.2	IMP	ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0003310	pancreatic A cell differentiation	nkx6.2	IMP	ZFIN:ZDB-MRPHLNO-100610-1,ZFIN:ZDB-MRPHLNO-100610-2	Zfish	PMID:20122912
Biological Process	GO:0010455	positive regulation of cell fate commitment	Nkx6-2	IMP	MGI:MGI:2651850	Mouse	PMID:11567614
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:15629702
Biological Process	GO:0031641	regulation of myelination	Nkx6-2	IMP		Mouse	MGI:MGI:3521547|PMID:15601927
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nkx6-2	IGI	MGI:MGI:1206039	Mouse	PMID:11567614
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nkx6-2	IMP	MGI:MGI:2651850	Mouse	PMID:11567614
Biological Process	GO:0021522	spinal cord motor neuron differentiation	nkx6.2	IGI	ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-070810-3	Zfish	PMID:17376808
Biological Process	GO:0021522	spinal cord motor neuron differentiation	nkx6.2	IMP	ZFIN:ZDB-MRPHLNO-070810-3	Zfish	PMID:17376808
Biological Process	GO:0021522	spinal cord motor neuron differentiation	nkx6.2	IGI	ZFIN:ZDB-GENE-980526-112,ZFIN:ZDB-MRPHLNO-050201-3,ZFIN:ZDB-MRPHLNO-070810-3	Zfish	PMID:17376808
Biological Process	GO:0003309	type B pancreatic cell differentiation	nkx6.2	IGI	ZFIN:ZDB-MRPHLNO-100609-7,ZFIN:ZDB-MRPHLNO-100610-1	Zfish	PMID:20122912
Biological Process	GO:0003309	type B pancreatic cell differentiation	nkx6.2	IMP	ZFIN:ZDB-MRPHLNO-100610-1,ZFIN:ZDB-MRPHLNO-100610-2	Zfish	PMID:20122912

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern