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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nlgn1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlgn1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0050839cell adhesion molecule bindingNlgn1IPIUniProtKB:Q63373RatPMID:15797875|RGD:8554205
Molecular FunctionGO:0050839cell adhesion molecule bindingNlgn1IPIUniProtKB:Q63373RatPMID:19730411|RGD:8554379
Molecular FunctionGO:0042802identical protein bindingNlgn1IPIUniProtKB:Q62765RatPMID:19730411|RGD:8554379
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IPIUniProtKB:P0DI97MouseMGI:MGI:5284755|PMID:19098102
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IMPMouseMGI:MGI:3694190|PMID:10892652
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IPIUniProtKB:P0DI97MouseMGI:MGI:2665153|PMID:12796785
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IPIUniProtKB:Q63373RatPMID:14522992|RGD:13210536
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IPIUniProtKB:Q63373RatPMID:15797875|RGD:8554205
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IPIRGD:628659RatPMID:18093522|RGD:2314457
Molecular FunctionGO:0042043neurexin family protein bindingNlgn1IPIUniProtKB:Q63373RatPMID:19730411|RGD:8554379
Molecular FunctionGO:0030165PDZ domain bindingNLGN1IDAHumanPMID:17474715
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:P58400-1MouseMGI:MGI:5916338|PMID:18084303
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:O14522MouseMGI:MGI:5508578|PMID:19816407
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:P97924-6MouseMGI:MGI:5908529|PMID:26078884
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:P97924-5MouseMGI:MGI:6489167|PMID:31801062
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:Q28146RatPMID:19730411|RGD:8554379
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:Q63373-3RatPMID:20543817|RGD:8553972
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:F1M0Z1RatPMID:31801062|RGD:150521626
Molecular FunctionGO:0005515protein bindingNlgn1IPIUniProtKB:P97924-5RatPMID:31801062|RGD:150521626
Molecular FunctionGO:0044877protein-containing complex bindingNlgn1IDARatPMID:18093522|RGD:2314457
Molecular FunctionGO:0097110scaffold protein bindingNLGN1IDAHumanPMID:17474715
Molecular FunctionGO:0038023signaling receptor activityNlgn1IDARatPMID:15797875|RGD:8554205
Cellular ComponentGO:0009986cell surfaceNlgn1IDAMouseMGI:MGI:5908777|PMID:26440732
Cellular ComponentGO:0009986cell surfaceNlgn1IDAMousePMID:23791195
Cellular ComponentGO:0009986cell surfaceNlgn1IDARatPMID:15797875|RGD:8554205
Cellular ComponentGO:0009986cell surfaceNlgn1IDARatPMID:19730411|RGD:8554379
Cellular ComponentGO:0030425dendriteNlgn1IDARatPMID:17582332|RGD:8553502
Cellular ComponentGO:0030425dendriteNlgn1IDARatPMID:20534458|RGD:10047242
Cellular ComponentGO:0043198dendritic shaftNlgn1IDARatPMID:22539981|RGD:9831126
Cellular ComponentGO:0043197dendritic spineNlgn1IDARatPMID:15519238|RGD:10047210
Cellular ComponentGO:0009897external side of plasma membraneNlgn1IDAMousePMID:20573900
Cellular ComponentGO:0032433filopodium tipNlgn1IDARatPMID:19450252|RGD:8553605
Cellular ComponentGO:0098978glutamatergic synapseNlgn1IDAMousePMID:15620359
Cellular ComponentGO:0098978glutamatergic synapseNlgn1IMPMousePMID:15620359
Cellular ComponentGO:0098978glutamatergic synapseNlgn1IDARatPMID:9927700|RGD:13702339
Cellular ComponentGO:0005794Golgi apparatusNlgn1IDARatPMID:15519238|RGD:10047210
Cellular ComponentGO:0005886plasma membraneNLGN1IMPHumanPMID:28841651
Cellular ComponentGO:0005886plasma membraneNlgn1IMPMouseMGI:MGI:3694190|PMID:10892652
Cellular ComponentGO:0005886plasma membraneNlgn1IDARatPMID:15519238|RGD:10047210
Cellular ComponentGO:0099634postsynaptic specialization membraneNlgn1IDARatPMID:9927700|RGD:13702339
Cellular ComponentGO:0099634postsynaptic specialization membraneNlgn1IDARatPMID:15519238|RGD:10047210
Cellular ComponentGO:0099634postsynaptic specialization membraneNlgn1IDARatPMID:19450252|RGD:8553605
Cellular ComponentGO:0098635protein complex involved in cell-cell adhesionNLGN1EXPHumanPMID:18084303
Cellular ComponentGO:0098635protein complex involved in cell-cell adhesionNlgn1EXPMouseMGI:MGI:5916338|PMID:18084303
Cellular ComponentGO:0043235receptor complexNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Cellular ComponentGO:0045202synapseNlgn1IDAMousePMID:12202822
Cellular ComponentGO:0045202synapseNlgn1IDAMousePMID:15681343
Cellular ComponentGO:0045202synapseNlgn1IDARatPMID:17582332|RGD:8553502
Cellular ComponentGO:0045202synapseNlgn1IDARatPMID:9278515|RGD:8554758
Biological ProcessGO:0097113AMPA glutamate receptor clusteringNlgn1IMPMouseMGI:MGI:5320256|PMID:21940442
Biological ProcessGO:0097113AMPA glutamate receptor clusteringNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0097113AMPA glutamate receptor clusteringNlgn1IMPRatPMID:21940442|RGD:8553843
Biological ProcessGO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesNlgn1IDARatPMID:9325340|RGD:8554612
Biological ProcessGO:0071277cellular response to calcium ionNlgn1IDARatPMID:14522992|RGD:13210536
Biological ProcessGO:0048789cytoskeletal matrix organization at active zoneNlgn1IMPMouseMGI:MGI:4355770|PMID:19628693
Biological ProcessGO:0048789cytoskeletal matrix organization at active zoneNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:0045184establishment of protein localizationNlgn1IMPMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:1904861excitatory synapse assemblyNlgn1IDAMouseMGI:MGI:5780536|PMID:22960622
Biological ProcessGO:1904861excitatory synapse assemblyNlgn1IMPMouseMGI:MGI:5908777|PMID:26440732
Biological ProcessGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0060291long-term synaptic potentiationNlgn1IMPRatPMID:23083734|RGD:9831154
Biological ProcessGO:0050804modulation of chemical synaptic transmissionNlgn1IGIMGI:MGI:2681835MousePMID:16982420
Biological ProcessGO:0050804modulation of chemical synaptic transmissionNlgn1IMPRatPMID:25428619|RGD:11554338
Biological ProcessGO:0061002negative regulation of dendritic spine morphogenesisNLGN1IGIUniProtKB:Q99K10HumanPMID:23143522
Biological ProcessGO:0061002negative regulation of dendritic spine morphogenesisNlgn1IMPMouseMGI:MGI:5493186|PMID:23143522
Biological ProcessGO:0007399nervous system developmentNLGN1IMPHumanPMID:28841651
Biological ProcessGO:0007399nervous system developmentNlgn1IDAMouseMGI:MGI:3694190|PMID:10892652
Biological ProcessGO:0007399nervous system developmentNlgn1IMPMouseMGI:MGI:5915076|PMID:28841651
Biological ProcessGO:0097115neurexin clustering involved in presynaptic membrane assemblyNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0007158neuron cell-cell adhesionNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0007158neuron cell-cell adhesionNlgn1IDARatPMID:15797875|RGD:8554205
Biological ProcessGO:0140058neuron projection arborizationNlgn1IGIUniProtKB:P58400RatPMID:22750515|RGD:13210562
Biological ProcessGO:0031175neuron projection developmentNLGN1IDAHumanPMID:22750515
Biological ProcessGO:0031175neuron projection developmentNlgn1IGIUniProtKB:P58400RatPMID:22750515|RGD:13210562
Biological ProcessGO:0097114NMDA glutamate receptor clusteringNlgn1IDARatPMID:19450252|RGD:8553605
Biological ProcessGO:0010841positive regulation of circadian sleep/wake cycle, wakefulnessNlgn1IMPMouseMGI:MGI:5492265|PMID:23716671
Biological ProcessGO:0060999positive regulation of dendritic spine developmentNLGN1IGIUniProtKB:Q99K10HumanPMID:23143522
Biological ProcessGO:0060999positive regulation of dendritic spine developmentNlgn1IMPMouseMGI:MGI:5493186|PMID:23143522
Biological ProcessGO:0060999positive regulation of dendritic spine developmentNlgn1IMPRatPMID:15681343|RGD:8553420
Biological ProcessGO:0060999positive regulation of dendritic spine developmentNlgn1IDARatPMID:17582332|RGD:8553502
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNLGN1IGIUniProtKB:Q99K10HumanPMID:23143522
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNlgn1IMPMouseMGI:MGI:5493186|PMID:23143522
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNlgn1IDAMouseMGI:MGI:3803801|PMID:17582332
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNlgn1IDARatPMID:17582332|RGD:8553502
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNlgn1IDARatPMID:19730411|RGD:8554379
Biological ProcessGO:0051491positive regulation of filopodium assemblyNlgn1IDARatPMID:12930820|RGD:8554754
Biological ProcessGO:1902533positive regulation of intracellular signal transductionNlgn1IDARatPMID:17582332|RGD:8553502
Biological ProcessGO:1905520positive regulation of presynaptic active zone assemblyNlgn1IDARatPMID:15797875|RGD:8554205
Biological ProcessGO:1902474positive regulation of protein localization to synapseNlgn1IMPRatPMID:15681343|RGD:8553420
Biological ProcessGO:1900029positive regulation of ruffle assemblyNlgn1IDARatPMID:12930820|RGD:8554754
Biological ProcessGO:0051965positive regulation of synapse assemblyNLGN1IDAHumanPMID:24613359
Biological ProcessGO:0051965positive regulation of synapse assemblyNlgn1IDAMousePMID:21356198
Biological ProcessGO:0051965positive regulation of synapse assemblyNlgn1IDARatPMID:15797875|RGD:8554205
Biological ProcessGO:0051965positive regulation of synapse assemblyNlgn1IDARatPMID:17582332|RGD:8553502
Biological ProcessGO:0032230positive regulation of synaptic transmission, GABAergicNlgn1IDARatPMID:12930820|RGD:8554754
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicNlgn1IDARatPMID:19730411|RGD:8554379
Biological ProcessGO:2000809positive regulation of synaptic vesicle clusteringNlgn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:1900244positive regulation of synaptic vesicle endocytosisNlgn1IMPMouseMGI:MGI:4355770|PMID:19628693
Biological ProcessGO:1900244positive regulation of synaptic vesicle endocytosisNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:2000302positive regulation of synaptic vesicle exocytosisNlgn1IMPMouseMGI:MGI:4355770|PMID:19628693
Biological ProcessGO:2000302positive regulation of synaptic vesicle exocytosisNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNlgn1IDAMouseMGI:MGI:5306551|PMID:20869594
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNlgn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNlgn1IMPRatPMID:12930820|RGD:8554754
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNlgn1IDARatPMID:19450252|RGD:8553605
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNlgn1IMPRatPMID:19450252|RGD:8553605
Biological ProcessGO:0097104postsynaptic membrane assemblyNlgn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097104postsynaptic membrane assemblyNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0098698postsynaptic specialization assemblyNlgn1IDAMousePMID:15620359
Biological ProcessGO:0098698postsynaptic specialization assemblyNlgn1IMPMousePMID:15620359
Biological ProcessGO:0097105presynaptic membrane assemblyNlgn1IDAMouseMGI:MGI:3694190|PMID:10892652
Biological ProcessGO:0097105presynaptic membrane assemblyNlgn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097105presynaptic membrane assemblyNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0097105presynaptic membrane assemblyNlgn1IDARatPMID:15797875|RGD:8554205
Biological ProcessGO:0097105presynaptic membrane assemblyNlgn1IDARatPMID:19730411|RGD:8554379
Biological ProcessGO:0035418protein localization to synapseNlgn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0035418protein localization to synapseNlgn1IDAMouseMGI:MGI:5780536|PMID:22960622
Biological ProcessGO:0006605protein targetingNlgn1IDARatPMID:9278515|RGD:8554758
Biological ProcessGO:0097120receptor localization to synapseNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:2000311regulation of AMPA receptor activityNlgn1IDARatPMID:17582332|RGD:8553502
Biological ProcessGO:0045664regulation of neuron differentiationNlgn1IDAMouseMGI:MGI:3694190|PMID:10892652
Biological ProcessGO:2000310regulation of NMDA receptor activityNLGN1IGIUniProtKB:Q99K10HumanPMID:23143522
Biological ProcessGO:2000310regulation of NMDA receptor activityNlgn1IDAMouseMGI:MGI:3803801|PMID:17582332
Biological ProcessGO:2000310regulation of NMDA receptor activityNlgn1IMPMouseMGI:MGI:5493186|PMID:23143522
Biological ProcessGO:2000310regulation of NMDA receptor activityNlgn1IDARatPMID:17582332|RGD:8553502
Biological ProcessGO:2000310regulation of NMDA receptor activityNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:2000310regulation of NMDA receptor activityNlgn1IMPRatPMID:25428619|RGD:11554338
Biological ProcessGO:0099174regulation of presynapse organizationNlgn1EXPRatPMID:10892652|RGD:13702379
Biological ProcessGO:0099174regulation of presynapse organizationNlgn1IDARatPMID:10892652|RGD:13702379
Biological ProcessGO:0099174regulation of presynapse organizationNlgn1IMPRatPMID:10892652|RGD:13702379
Biological ProcessGO:0002087regulation of respiratory gaseous exchange by nervous system processNlgn1IGIMGI:MGI:2444609MousePMID:16982420
Biological ProcessGO:0098942retrograde trans-synaptic signaling by trans-synaptic protein complexNlgn1IMPRatPMID:17237775|RGD:12050104
Biological ProcessGO:0002040sprouting angiogenesisnlgn1IGIZFIN:ZDB-MRPHLNO-080516-7,ZFIN:ZDB-MRPHLNO-120719-4ZfishPMID:22516065
Biological ProcessGO:0002040sprouting angiogenesisnlgn1IGIZFIN:ZDB-MRPHLNO-120719-2,ZFIN:ZDB-MRPHLNO-120719-4ZfishPMID:22516065
Biological ProcessGO:0007416synapse assemblyNlgn1IDAMouseMGI:MGI:3694190|PMID:10892652
Biological ProcessGO:0007416synapse assemblyNlgn1IDAMousePMID:21356198
Biological ProcessGO:0007416synapse assemblyNlgn1IDARatPMID:15797875|RGD:8554205
Biological ProcessGO:0050808synapse organizationNlgn1IGIMGI:MGI:2444609MousePMID:21788371
Biological ProcessGO:0050808synapse organizationNlgn1IGIMGI:MGI:2389173MousePMID:21788371
Biological ProcessGO:0050808synapse organizationNlgn1IGIMGI:MGI:2389174MousePMID:21788371
Biological ProcessGO:0050808synapse organizationNlgn1IDARatPMID:15681343|RGD:8553420
Biological ProcessGO:0099560synaptic membrane adhesionNlgn1IMPMouseMGI:MGI:5763518|PMID:26771491
Biological ProcessGO:0099560synaptic membrane adhesionNlgn1IDAMousePMID:12796785
Biological ProcessGO:0099560synaptic membrane adhesionNlgn1IMPMousePMID:12796785
Biological ProcessGO:0097091synaptic vesicle clusteringNlgn1IDAMouseMGI:MGI:3694190|PMID:10892652
Biological ProcessGO:0097091synaptic vesicle clusteringNlgn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0097091synaptic vesicle clusteringNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:0097091synaptic vesicle clusteringNlgn1IDARatPMID:20534458|RGD:10047242
Biological ProcessGO:0016080synaptic vesicle targetingNlgn1IMPMouseMGI:MGI:3694190|PMID:10892652
Biological ProcessGO:0048489synaptic vesicle transportNlgn1IMPRatPMID:19628693|RGD:8554760
Biological ProcessGO:0072553terminal button organizationNlgn1IMPMouseMGI:MGI:4355770|PMID:19628693
Biological ProcessGO:0072553terminal button organizationNlgn1IMPRatPMID:19628693|RGD:8554760

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory