Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nlgn3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NLGN3
- Mouse genes Nlgn3
- Rat genes Nlgn3
- Zfish genes nlgn3a,nlgn3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlgn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	Nlgn3	IPI	UniProtKB:Q63373	Rat	PMID:15152050\|RGD:8553271
Molecular Function	GO:0060090	molecular adaptor activity	NLGN3	EXP		Human	PMID:18456828
Molecular Function	GO:0060090	molecular adaptor activity	NLGN3	IDA		Human	PMID:18456828
Molecular Function	GO:0042043	neurexin family protein binding	Nlgn3	IPI	UniProtKB:Q63373	Rat	PMID:15152050\|RGD:8553271
Molecular Function	GO:0005515	protein binding	NLGN3	IPI	UniProtKB:Q9NY99	Human	PMID:17292328
Molecular Function	GO:0097110	scaffold protein binding	NLGN3	IPI	UniProtKB:Q9NY99	Human	PMID:17292328
Molecular Function	GO:0038023	signaling receptor activity	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Cellular Component	GO:0009986	cell surface	NLGN3	IDA		Human	PMID:15150161
Cellular Component	GO:0009986	cell surface	NLGN3	IDA		Human	PMID:17292328
Cellular Component	GO:0009986	cell surface	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Cellular Component	GO:0030425	dendrite	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0030139	endocytic vesicle	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Cellular Component	GO:0060076	excitatory synapse	NLGN3	IDA		Human	PMID:15620359
Cellular Component	GO:0060076	excitatory synapse	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0060076	excitatory synapse	Nlgn3	IDA		Rat	PMID:19914352\|RGD:8554031
Cellular Component	GO:0098982	GABA-ergic synapse	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0098978	glutamatergic synapse	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0060077	inhibitory synapse	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0060077	inhibitory synapse	Nlgn3	IDA		Rat	PMID:19914352\|RGD:8554031
Cellular Component	GO:0043025	neuronal cell body	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0045211	postsynaptic membrane	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Cellular Component	GO:0099634	postsynaptic specialization membrane	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Cellular Component	GO:0045202	synapse	Nlgn3	IDA		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:0030534	adult behavior	NLGN3	IMP		Human	PMID:12669065
Biological Process	GO:0048675	axon extension	Nlgn3	IMP		Rat	PMID:19406211\|RGD:8554851
Biological Process	GO:0042745	circadian sleep/wake cycle	Nlgn3	IMP		Rat	PMID:28958035\|RGD:126790492
Biological Process	GO:0060079	excitatory postsynaptic potential	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0060080	inhibitory postsynaptic potential	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0060080	inhibitory postsynaptic potential	Nlgn3	IMP	MGI:MGI:3758949	Mouse	PMID:17823315
Biological Process	GO:0060080	inhibitory postsynaptic potential	Nlgn3	IDA		Rat	PMID:19406211\|RGD:8554851
Biological Process	GO:0007612	learning	NLGN3	IMP		Human	PMID:12669065
Biological Process	GO:0060291	long-term synaptic potentiation	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Nlgn3	IGI	MGI:MGI:2681835	Mouse	PMID:16982420
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Nlgn3	IGI	MGI:MGI:2179435	Mouse	PMID:16982420
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0007158	neuron cell-cell adhesion	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0048709	oligodendrocyte differentiation	Nlgn3	IMP		Mouse	PMID:19139271
Biological Process	GO:2000969	positive regulation of AMPA receptor activity	Nlgn3	IMP		Mouse	MGI:MGI:5320268\|PMID:21642956
Biological Process	GO:0060999	positive regulation of dendritic spine development	Nlgn3	IMP		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Nlgn3	IMP		Mouse	MGI:MGI:5320268\|PMID:21642956
Biological Process	GO:0097151	positive regulation of inhibitory postsynaptic potential	Nlgn3	IDA		Rat	PMID:19406211\|RGD:8554851
Biological Process	GO:1902474	positive regulation of protein localization to synapse	Nlgn3	IMP		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:0051965	positive regulation of synapse assembly	Nlgn3	IMP		Mouse	MGI:MGI:5320268\|PMID:21642956
Biological Process	GO:0051965	positive regulation of synapse assembly	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Nlgn3	IMP		Mouse	MGI:MGI:5320268\|PMID:21642956
Biological Process	GO:2000809	positive regulation of synaptic vesicle clustering	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0097104	postsynaptic membrane assembly	Nlgn3	IMP		Mouse	MGI:MGI:5320268\|PMID:21642956
Biological Process	GO:0098698	postsynaptic specialization assembly	Nlgn3	IDA		Rat	PMID:17897391\|RGD:9831151
Biological Process	GO:0060134	prepulse inhibition	Nlgn3	IMP		Rat	PMID:28958035\|RGD:126790492
Biological Process	GO:0097105	presynaptic membrane assembly	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0006898	receptor-mediated endocytosis	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:2000311	regulation of AMPA receptor activity	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:2000310	regulation of NMDA receptor activity	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Nlgn3	IGI	MGI:MGI:2179435	Mouse	PMID:16982420
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Nlgn3	IGI	MGI:MGI:2681835	Mouse	PMID:16982420
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:2000331	regulation of terminal button organization	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0060024	rhythmic synaptic transmission	Nlgn3	IMP		Rat	PMID:19406211\|RGD:8554851
Biological Process	GO:0035176	social behavior	NLGN3	IMP		Human	PMID:12669065
Biological Process	GO:0035176	social behavior	Nlgn3	IMP		Mouse	MGI:MGI:5286761\|PMID:21808020
Biological Process	GO:0035176	social behavior	Nlgn3	IMP	MGI:MGI:3758949	Mouse	PMID:17823315
Biological Process	GO:0007416	synapse assembly	Nlgn3	IDA		Rat	PMID:15797875\|RGD:8554205
Biological Process	GO:0050808	synapse organization	NLGN3	IMP		Human	PMID:15150161
Biological Process	GO:0050808	synapse organization	Nlgn3	IGI	MGI:MGI:2389173	Mouse	PMID:21788371
Biological Process	GO:0050808	synapse organization	Nlgn3	IGI	MGI:MGI:2179435	Mouse	PMID:21788371
Biological Process	GO:0050808	synapse organization	Nlgn3	IGI	MGI:MGI:2389174	Mouse	PMID:21788371
Biological Process	GO:0050808	synapse organization	Nlgn3	IDA		Rat	PMID:15681343\|RGD:8553420
Biological Process	GO:0008542	visual learning	Nlgn3	IMP	MGI:MGI:3758949	Mouse	PMID:17823315
Biological Process	GO:0071625	vocalization behavior	NLGN3	IMP		Human	PMID:12669065

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.