Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLK
  • Mouse genes Nlk
  • Rat genes Nlk
  • Zfish genes nlk1,nlk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Nlk	IDA		Mouse	MGI:MGI:1195806|PMID:9448268
Molecular Function	GO:0140297	DNA-binding transcription factor binding	NLK	IPI	UniProtKB:Q9NQB0	Human	PMID:16714285
Molecular Function	GO:0140297	DNA-binding transcription factor binding	NLK	IPI	UniProtKB:Q9Y2D1	Human	PMID:25512613
Molecular Function	GO:0000287	magnesium ion binding	Nlk	IDA		Mouse	MGI:MGI:1195806|PMID:9448268
Molecular Function	GO:0004707	MAP kinase activity	Nlk	IDA		Mouse	MGI:MGI:1195806|PMID:9448268
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:O43293	Human	PMID:21454679
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q9H4I2	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q13485	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q96PM5	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q14186	Human	PMID:22773187
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q13485	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P28799	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q2TAL8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q6L8G9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q9BYR5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q9H4I2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P28799	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P28799	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q9H4I2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:Q9UHB4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NLK	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nlk	IPI	UniProtKB:Q9QZR5	Mouse	MGI:MGI:3040155|PMID:15082531
Molecular Function	GO:0005515	protein binding	Nlk	IPI	UniProtKB:Q60929	Mouse	MGI:MGI:3843420|PMID:17785444
Molecular Function	GO:0004672	protein kinase activity	Nlk	IDA		Mouse	PMID:9448268
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Nlk	IDA		Mouse	MGI:MGI:3843436|PMID:15004007
Molecular Function	GO:0042169	SH2 domain binding	Nlk	IPI	UniProtKB:P42227	Mouse	MGI:MGI:3843436|PMID:15004007
Molecular Function	GO:0031625	ubiquitin protein ligase binding	NLK	IPI	UniProtKB:Q8WVD3	Human	PMID:16714285
Cellular Component	GO:0005634	nucleus	Nlk	IDA		Mouse	PMID:9448268
Biological Process	GO:0035556	intracellular signal transduction	Nlk	IDA		Mouse	MGI:MGI:1195806|PMID:9448268
Biological Process	GO:0030901	midbrain development	nlk2	IMP	ZFIN:ZDB-MRPHLNO-120511-1	Zfish	PMID:22373574
Biological Process	GO:0030901	midbrain development	nlk2	IMP	ZFIN:ZDB-MRPHLNO-120511-2	Zfish	PMID:22373574
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	nlk1	IMP	ZFIN:ZDB-MRPHLNO-080717-1	Zfish	PMID:20118921
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	nlk1	IDA		Zfish	PMID:20118921
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Nlk	IMP		Mouse	MGI:MGI:3040155|PMID:15082531
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Nlk	IDA		Mouse	MGI:MGI:3843420|PMID:17785444
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	nlk2	IDA		Zfish	PMID:22373574
Biological Process	GO:0050769	positive regulation of neurogenesis	nlk1	IMP	ZFIN:ZDB-MRPHLNO-080717-1	Zfish	PMID:20118921
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	nlk1	IMP		Zfish	PMID:15151990
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	nlk2	IMP	ZFIN:ZDB-GENO-020621-2,ZFIN:ZDB-MRPHLNO-120511-1	Zfish	PMID:22373574
Biological Process	GO:0046777	protein autophosphorylation	Nlk	IDA		Mouse	PMID:9448268
Biological Process	GO:0006468	protein phosphorylation	Nlk	IDA		Mouse	MGI:MGI:1195806|PMID:9448268
Biological Process	GO:0050821	protein stabilization	NLK	IDA		Human	PMID:25512613
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nlk	IMP		Mouse	MGI:MGI:3852311|PMID:14720327
Biological Process	GO:0042501	serine phosphorylation of STAT protein	Nlk	IDA		Mouse	MGI:MGI:3843436|PMID:15004007
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	NLK	IMP		Human	PMID:15004007

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern