Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nlrc4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NLRC4
- Mouse genes Nlrc4
- Rat genes Nlrc4
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	NLRC4	IDA		Human	PMID:15882992
Molecular Function	GO:0089720	caspase binding	NLRC4	IPI	UniProtKB:P29466	Human	PMID:15882992
Molecular Function	GO:0061133	endopeptidase activator activity	NLRC4	IGI	UniProtKB:P10749,UniProtKB:P29466	Human	PMID:15882992
Molecular Function	GO:0042802	identical protein binding	NLRC4	IPI	UniProtKB:Q9NPP4	Human	PMID:11374873
Molecular Function	GO:0042802	identical protein binding	NLRC4	IPI	UniProtKB:Q9NPP4	Human	PMID:11390368
Molecular Function	GO:0042802	identical protein binding	NLRC4	IPI	UniProtKB:Q9NPP4	Human	PMID:15882992
Molecular Function	GO:0042802	identical protein binding	Nlrc4	IPI	UniProtKB:Q3UP24	Mouse	MGI:MGI:5926614\|PMID:26585513
Molecular Function	GO:0042802	identical protein binding	Nlrc4	IPI	UniProtKB:Q3UP24	Mouse	MGI:MGI:5917766\|PMID:26449475
Molecular Function	GO:0042802	identical protein binding	Nlrc4	IPI	UniProtKB:Q3UP24	Mouse	MGI:MGI:5914198\|PMID:26449474
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:P29466	Human	PMID:11374873
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:P29466	Human	PMID:11390368
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:O95999	Human	PMID:11472070
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:Q9C000	Human	PMID:11472070
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:Q9HC29	Human	PMID:11472070
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:P29466	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:Q9C000	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:Q9HC29	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:Q9Y239	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:P29466	Human	PMID:17418785
Molecular Function	GO:0005515	protein binding	NLRC4	IPI	UniProtKB:P19525	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	Nlrc4	IPI	UniProtKB:Q9R016	Mouse	MGI:MGI:5917987\|PMID:23765277
Molecular Function	GO:0005515	protein binding	Nlrc4	IPI	UniProtKB:P29452	Mouse	MGI:MGI:5444805\|PMID:22885697
Molecular Function	GO:0005515	protein binding	Nlrc4	IPI	UniProtKB:Q9R016	Mouse	MGI:MGI:6355647\|PMID:29146805
Molecular Function	GO:0005515	protein binding	Nlrc4	IPI	UniProtKB:Q9R016	Mouse	MGI:MGI:5926614\|PMID:26585513
Molecular Function	GO:0005515	protein binding	Nlrc4	IPI	UniProtKB:P29452\|UniProtKB:Q9R016	Mouse	MGI:MGI:5914198\|PMID:26449474
Molecular Function	GO:0005515	protein binding	Nlrc4	IPI	UniProtKB:Q9R016	Mouse	MGI:MGI:5917766\|PMID:26449475
Molecular Function	GO:0042803	protein homodimerization activity	NLRC4	IDA		Human	PMID:15107016
Cellular Component	GO:0005829	cytosol	NLRC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Nlrc4	IDA		Mouse	MGI:MGI:5444805\|PMID:22885697
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NLRC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072557	IPAF inflammasome complex	Nlrc4	IDA		Mouse	MGI:MGI:5289703\|PMID:21874021
Cellular Component	GO:0072557	IPAF inflammasome complex	Nlrc4	IDA		Mouse	MGI:MGI:5444805\|PMID:22885697
Cellular Component	GO:0005886	plasma membrane	NLRC4	IDA		Human	GO_REF:0000052
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	NLRC4	IGI	UniProtKB:P10749,UniProtKB:P29466	Human	PMID:15882992
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	NLRC4	IMP		Human	PMID:15882992
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	NLRC4	IDA		Human	PMID:15030775
Biological Process	GO:0002218	activation of innate immune response	Nlrc4	IMP		Mouse	MGI:MGI:3662990\|PMID:16648852
Biological Process	GO:0042742	defense response to bacterium	NLRC4	IDA		Human	PMID:15107016
Biological Process	GO:0042742	defense response to bacterium	Nlrc4	IMP		Mouse	MGI:MGI:3662989\|PMID:16648853
Biological Process	GO:0042742	defense response to bacterium	Nlrc4	IMP		Mouse	MGI:MGI:5289703\|PMID:21874021
Biological Process	GO:0042742	defense response to bacterium	Nlrc4	IMP		Mouse	MGI:MGI:5428366\|PMID:22484733
Biological Process	GO:0042742	defense response to bacterium	Nlrc4	IMP		Mouse	MGI:MGI:5444805\|PMID:22885697
Biological Process	GO:0042742	defense response to bacterium	Nlrc4	IMP		Mouse	MGI:MGI:3662990\|PMID:16648852
Biological Process	GO:0016045	detection of bacterium	NLRC4	IDA		Human	PMID:15107016
Biological Process	GO:0016045	detection of bacterium	Nlrc4	IMP		Mouse	MGI:MGI:5444805\|PMID:22885697
Biological Process	GO:0006954	inflammatory response	Nlrc4	IMP		Mouse	MGI:MGI:5444805\|PMID:22885697
Biological Process	GO:0006954	inflammatory response	Nlrc4	IMP		Mouse	MGI:MGI:5289703\|PMID:21874021
Biological Process	GO:0006954	inflammatory response	Nlrc4	IMP		Mouse	MGI:MGI:5428366\|PMID:22484733
Biological Process	GO:0006954	inflammatory response	Nlrc4	IMP		Mouse	MGI:MGI:3662990\|PMID:16648852
Biological Process	GO:0006954	inflammatory response	Nlrc4	IMP		Mouse	MGI:MGI:3662989\|PMID:16648853
Biological Process	GO:0006954	inflammatory response	Nlrc4	IMP	MGI:MGI:3046934	Mouse	PMID:15190255
Biological Process	GO:0043065	positive regulation of apoptotic process	NLRC4	IDA		Human	PMID:12646168
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRC4	IGI	UniProtKB:P10749,UniProtKB:P29466	Human	PMID:15882992
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrc4	IMP		Mouse	MGI:MGI:3662989\|PMID:16648853
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrc4	IMP		Mouse	MGI:MGI:3662990\|PMID:16648852
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrc4	IMP		Mouse	MGI:MGI:5428366\|PMID:22484733
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NLRC4	IDA		Human	PMID:12646168
Biological Process	GO:0010954	positive regulation of protein processing	NLRC4	IGI	UniProtKB:P10749,UniProtKB:P29466	Human	PMID:15882992
Biological Process	GO:0051260	protein homooligomerization	Nlrc4	IDA		Mouse	MGI:MGI:5289703\|PMID:21874021
Biological Process	GO:0070269	pyroptosis	Nlrc4	IMP		Mouse	MGI:MGI:5444805\|PMID:22885697
Biological Process	GO:0070269	pyroptosis	Nlrc4	IMP		Mouse	MGI:MGI:3662990\|PMID:16648852
Biological Process	GO:0070269	pyroptosis	Nlrc4	IMP		Mouse	MGI:MGI:3662989\|PMID:16648853
Biological Process	GO:0070269	pyroptosis	Nlrc4	IMP		Mouse	MGI:MGI:5289703\|PMID:21874021
Biological Process	GO:0070269	pyroptosis	Nlrc4	IMP		Mouse	MGI:MGI:5428366\|PMID:22484733
Biological Process	GO:0042981	regulation of apoptotic process	Nlrc4	IMP	MGI:MGI:3046934	Mouse	PMID:15190255
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	Nlrc4	IMP	MGI:MGI:3046934	Mouse	PMID:15190255

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.