Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLRC5
  • Mouse genes Nlrc5
  • Rat genes Nlrc5
  • Zfish genes nlrc5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NLRC5	IPI	UniProtKB:O14920	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	NLRC5	IPI	UniProtKB:O15111	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	NLRC5	IPI	UniProtKB:O95786	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	NLRC5	IPI	UniProtKB:Q9BYX4	Human	PMID:20434986
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NLRC5	IDA		Human	PMID:20639463
Cellular Component	GO:0005813	centrosome	NLRC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	NLRC5	IDA		Human	PMID:20061403
Cellular Component	GO:0005737	cytoplasm	NLRC5	IDA		Human	PMID:20434986
Cellular Component	GO:0005829	cytosol	NLRC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	NLRC5	IDA		Human	PMID:20639463
Cellular Component	GO:0005829	cytosol	Nlrc5	IDA		Mouse	MGI:MGI:5009351|PMID:20639463
Cellular Component	GO:0005634	nucleus	NLRC5	IDA		Human	PMID:20639463
Cellular Component	GO:0005634	nucleus	Nlrc5	IDA		Mouse	MGI:MGI:5009351|PMID:20639463
Biological Process	GO:0098586	cellular response to virus	nlrc5	IDA		Zfish	PMID:29454830
Biological Process	GO:0051607	defense response to virus	NLRC5	IEP		Human	PMID:20061403
Biological Process	GO:0045087	innate immune response	NLRC5	IMP		Human	PMID:20434986
Biological Process	GO:0045087	innate immune response	Nlrc5	IMP		Mouse	MGI:MGI:4454346|PMID:20434986
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	NLRC5	IDA		Human	PMID:20434986
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Nlrc5	IDA		Mouse	MGI:MGI:4454346|PMID:20434986
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	NLRC5	IDA		Human	PMID:20434986
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Nlrc5	IDA		Mouse	MGI:MGI:4454346|PMID:20434986
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	NLRC5	IDA		Human	PMID:20639463
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NLRC5	IDA		Human	PMID:20639463
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	NLRC5	IDA		Human	PMID:20061403
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	NLRC5	IDA		Human	PMID:20061403
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	NLRC5	IMP		Human	PMID:20639463
Biological Process	GO:0050776	regulation of immune response	nlrc5	IDA		Zfish	PMID:29454830
Biological Process	GO:0043549	regulation of kinase activity	NLRC5	IDA		Human	PMID:20434986
Biological Process	GO:0009617	response to bacterium	Nlrc5	IEP		Mouse	PMID:23012479
Biological Process	GO:0009617	response to bacterium	nlrc5	IDA		Zfish	PMID:29454830

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern