Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLRP12
  • Mouse genes Nlrp12
  • Rat genes Nlrp12
  • Zfish genes nlrc10,nlrc11,nlrc7,nlrc9,si:cabz01069012.2,si:ch211-114l13.1,si:ch211-114l13.13,si:ch211-133h13.1,si:ch211-15j1.1,si:ch211-15j1.3,si:ch211-15j1.4,si:ch211-15j1.5,si:ch211-171l17.4,si:ch211-181d7.1,si:ch211-187g4.1,si:ch211-191a16.2,si:ch211-191a16.5,si:ch211-194e1.7,si:ch211-194e1.9,si:ch211-196h16.5,si:ch211-196h24.1,si:ch211-197e7.1,si:ch211-201o1.1,si:ch211-203c5.3,si:ch211-205a14.1,si:ch211-207e19.2,si:ch211-213a13.9,si:ch211-214b16.3,si:ch211-226o13.1,si:ch211-227e10.6,si:ch211-227p7.5,si:ch211-22k7.9,si:ch211-232d10.1,si:ch211-236p5.2,si:ch211-236p5.3,si:ch211-237a4.2,si:ch211-238e22.8,si:ch211-250k18.7,si:ch211-255g12.8,si:ch211-271g18.1,si:ch211-278p9.1,si:ch211-76m11.3,si:ch211-76m11.5,si:ch211-76m11.8,si:ch73-233m11.2,si:ch73-236c18.2,si:ch73-236c18.5,si:ch73-236c18.7,si:ch73-50f9.4,si:dkey-11n14.1,si:dkey-121n8.7,si:dkey-124l13.1,si:dkey-151g22.1,si:dkey-165e24.1,si:dkey-165o8.1,si:dkey-178j11.5,si:dkey-193i10.4,si:dkey-222h21.1,si:dkey-222h21.10,si:dkey-222h21.11,si:dkey-222h21.2,si:dkey-222h21.3,si:dkey-222h21.7,si:dkey-222h21.8,si:dkey-222h21.9,si:dkey-233e3.2,si:dkey-264f17.2,si:dkey-26m3.3,si:dkey-27n6.1,si:dkey-29j8.1,si:dkey-51d8.1,si:dkey-61p9.9,si:dkey-71l4.4,si:dkeyp-100h4.1,si:dkeyp-35e5.5,si:dkeyp-4c4.1,si:dkeyp-4f2.1,si:rp71-7l19.2,si:zfos-364h11.1,zgc:110171,zgc:173709,zgc:174180,zgc:194906,zmp:0000001020
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrp12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:Q9ULZ3	Human	PMID:12019269
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:P51617	Human	PMID:16203735
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:Q99558	Human	PMID:17237370
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:Q9HC29	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:P08631	Human	PMID:32226298
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:Q9Y228	Human	PMID:32226298
Molecular Function	GO:0005515	protein binding	NLRP12	IPI	UniProtKB:P0DTD1:PRO_0000449623	Human	PMID:33372854
Molecular Function	GO:0005515	protein binding	Nlrp12	IPI	UniProtKB:P0DTD1:PRO_0000449623	Mouse	MGI:MGI:6695690|PMID:33372854
Molecular Function	GO:0005515	protein binding	Nlrp12	IPI	PR:Q60803	Mouse	PMID:22503542
Cellular Component	GO:0005737	cytoplasm	NLRP12	IDA		Human	PMID:12019269
Biological Process	GO:0071345	cellular response to cytokine stimulus	Nlrp12	IMP	MGI:MGI:4836357	Mouse	PMID:20861349
Biological Process	GO:0036336	dendritic cell migration	Nlrp12	IMP	MGI:MGI:4836357	Mouse	PMID:20861349
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Nlrp12	IMP	MGI:MGI:4836357	Mouse	PMID:22503542
Biological Process	GO:0001818	negative regulation of cytokine production	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Nlrp12	IMP	MGI:MGI:4836357	Mouse	PMID:22503542
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0050728	negative regulation of inflammatory response	NLRP12	IMP		Human	PMID:18230725
Biological Process	GO:0050728	negative regulation of inflammatory response	Nlrp12	IMP		Mouse	MGI:MGI:6285057|PMID:30212649
Biological Process	GO:0032692	negative regulation of interleukin-1 production	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0032715	negative regulation of interleukin-6 production	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	NLRP12	IDA		Human	PMID:18230725
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	NLRP12	IDA		Human	PMID:17237370
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	Nlrp12	IMP	MGI:MGI:4836357	Mouse	PMID:22503542
Biological Process	GO:0031953	negative regulation of protein autophosphorylation	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0009968	negative regulation of signal transduction	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0045751	negative regulation of Toll signaling pathway	NLRP12	IDA		Human	PMID:16203735
Biological Process	GO:0038061	NIK/NF-kappaB signaling	Nlrp12	IMP	MGI:MGI:4836357	Mouse	PMID:22503542
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	NLRP12	IDA		Human	PMID:12759408
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NLRP12	IDA		Human	PMID:12019269
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	NLRP12	IDA		Human	PMID:12019269
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	NLRP12	IDA		Human	PMID:12019269

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern