Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NLRP1
  • Mouse genes Nlrp1a
  • Rat genes
  • Zfish genes nlrp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nlrp1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	NLRP1	IDA		Human	PMID:15212762
Molecular Function	GO:0005524	ATP binding	NLRP1	IDA		Human	PMID:33243852
Molecular Function	GO:0016887	ATP hydrolysis activity	NLRP1	IDA		Human	PMID:33243852
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	NLRP1	IDA		Human	PMID:22665479
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	NLRP1	IDA		Human	PMID:30291141
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	NLRP1	IDA		Human	PMID:33852854
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	NLRP1	IDA		Human	PMID:35594856
Molecular Function	GO:0003690	double-stranded DNA binding	NLRP1	IDA		Human	PMID:33243852
Molecular Function	GO:0003725	double-stranded RNA binding	NLRP1	IDA		Human	PMID:33243852
Molecular Function	GO:0019899	enzyme binding	NLRP1	IPI	UniProtKB:P42575	Human	PMID:11076957
Molecular Function	GO:0140693	molecular condensate scaffold activity	NLRP1	IDA		Human	PMID:33420028
Molecular Function	GO:0140693	molecular condensate scaffold activity	NLRP1	IDA		Human	PMID:33420033
Molecular Function	GO:0140677	molecular function activator activity	NLRP1	IDA		Human	PMID:22665479
Molecular Function	GO:0140677	molecular function activator activity	NLRP1	IDA		Human	PMID:33243852
Molecular Function	GO:0140677	molecular function activator activity	NLRP1	IDA		Human	PMID:33420028
Molecular Function	GO:0140677	molecular function activator activity	NLRP1	IDA		Human	PMID:33420033
Molecular Function	GO:0038187	pattern recognition receptor activity	NLRP1	IDA		Human	PMID:33243852
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q9NPP4	Human	PMID:11472070
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:P29466	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q9NPP4	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:P10415	Human	PMID:17418785
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:P29466	Human	PMID:17418785
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q07817	Human	PMID:17418785
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q9ULZ3	Human	PMID:17418785
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:P29466	Human	PMID:18511561
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:P10415	Human	PMID:19223583
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q07817-1	Human	PMID:19223583
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q9HC29	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:P19525	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q86TI2	Human	PMID:30291141
Molecular Function	GO:0005515	protein binding	NLRP1	IPI	UniProtKB:Q86TI2	Human	PMID:33731929
Molecular Function	GO:0005515	protein binding	Nlrp1a	IPI	UniProtKB:Q80SY9	Mouse	MGI:MGI:4943384|PMID:18511561
Molecular Function	GO:0019904	protein domain specific binding	NLRP1	IPI	UniProtKB:O95361	Human	PMID:16575408
Molecular Function	GO:0043621	protein self-association	NLRP1	IDA		Human	PMID:33420028
Molecular Function	GO:0043621	protein self-association	NLRP1	IDA		Human	PMID:33420033
Molecular Function	GO:0035591	signaling adaptor activity	NLRP1	IDA		Human	PMID:22665479
Molecular Function	GO:0030546	signaling receptor activator activity	NLRP1	IDA		Human	PMID:33243852
Cellular Component	GO:0061702	canonical inflammasome complex	nlrp1	IPI	ZFIN:ZDB-GENE-000616-3,ZFIN:ZDB-GENE-000511-2	Zfish	PMID:30150286
Cellular Component	GO:0061702	canonical inflammasome complex	nlrp1	IPI	ZFIN:ZDB-GENE-020812-1,ZFIN:ZDB-GENE-000511-2	Zfish	PMID:30150286
Cellular Component	GO:0005829	cytosol	NLRP1	IDA		Human	PMID:17164409
Cellular Component	GO:0005829	cytosol	NLRP1	IDA		Human	PMID:22665479
Cellular Component	GO:0005829	cytosol	NLRP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NLRP1	IPI		Human	PMID:17349957
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NLRP1	IDA		Human	PMID:12191486
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NLRP1	IDA		Human	PMID:30291141
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NLRP1	IDA		Human	PMID:33420028
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NLRP1	IDA		Human	PMID:33420033
Cellular Component	GO:0072558	NLRP1 inflammasome complex	nlrp1	IPI		Zfish	PMID:30150286|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0072558	NLRP1 inflammasome complex	nlrp1	IDA		Zfish	PMID:30150286|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0005654	nucleoplasm	NLRP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NLRP1	IDA		Human	PMID:17164409
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	NLRP1	IDA		Human	PMID:15212762
Biological Process	GO:0140374	antiviral innate immune response	NLRP1	IDA		Human	PMID:33093214
Biological Process	GO:0071493	cellular response to UV-B	NLRP1	IMP		Human	PMID:30096351
Biological Process	GO:0042742	defense response to bacterium	Nlrp1a	IDA		Mouse	PMID:16429160
Biological Process	GO:0051607	defense response to virus	NLRP1	IDA		Human	PMID:33093214
Biological Process	GO:0051607	defense response to virus	NLRP1	IDA		Human	PMID:33243852
Biological Process	GO:0051402	neuron apoptotic process	NLRP1	IDA		Human	PMID:15212762
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IDA		Human	PMID:22665479
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IMP		Human	PMID:27662089
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IMP		Human	PMID:31484767
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IDA		Human	PMID:33243852
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IDA		Human	PMID:33420028
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IDA		Human	PMID:33420033
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IDA		Human	PMID:33852854
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	NLRP1	IDA		Human	PMID:35594856
Biological Process	GO:0050729	positive regulation of inflammatory response	NLRP1	IDA		Human	PMID:12191486
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP1	IDA		Human	PMID:33243852
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NLRP1	IDA		Human	PMID:7642516
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nlrp1a	IDA		Mouse	MGI:MGI:4943384|PMID:18511561
Biological Process	GO:0097300	programmed necrotic cell death	Nlrp1a	IDA		Mouse	PMID:16429160
Biological Process	GO:0051260	protein homooligomerization	NLRP1	IDA		Human	PMID:33420028
Biological Process	GO:0051260	protein homooligomerization	NLRP1	IDA		Human	PMID:33420033
Biological Process	GO:0070269	pyroptosis	NLRP1	IDA		Human	PMID:33093214
Biological Process	GO:0032495	response to muramyl dipeptide	Nlrp1a	IDA		Mouse	MGI:MGI:4943384|PMID:18511561
Biological Process	GO:0097264	self proteolysis	NLRP1	IDA		Human	PMID:33093214
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	NLRP1	IMP		Human	PMID:30096351

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern